在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXO5 Antibody

  • 中文名稱:
    FBXO5兔多克隆抗體
  • 貨號(hào):
    CSB-PA008514GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    FBXO5
  • 別名:
    Early mitotic inhibitor 1 antibody; Emi 1 antibody; EMI1 antibody; F box only protein 5 antibody; F box protein 5 antibody; F box protein Fbx 5 antibody; F box protein Fbx5 antibody; F-box only protein 5 antibody; FBX5 antibody; FBX5_HUMAN antibody; Fbxo31 antibody; fbxo5 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human FBXO5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Regulator of APC activity during mitotic and meiotic cell cycle. During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex. During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase. Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment. As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities. Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence. During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization. Controls entry into the first meiotic division through inactivation of APC-FZR1 complex. Promotes migration and osteogenic differentiation of mesenchymal stem cells.
  • 基因功能參考文獻(xiàn):
    1. demonstration using human cell models that cell-cycle commitment is mediated by an EMI1-APC/C(CDH1) dual-negative feedback switch, in which EMI1 is both a substrate and an inhibitor of APC/C(CDH1) PMID: 29875408
    2. Both isoforms of FBXO5 promoted the migration and osteogenic differentiation potential of human periodontal ligament stem cells. PMID: 29850565
    3. Results from a study on gene variability markers in early-stage human embryos shows that FBXO5 is a putative variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    4. The fact that Emi1 overexpression promotes chromosome instability (CIN) and the formation of solid cancers in vivo indicates that Emi1 overexpression actively drives solid tumorigenesis. These novel mechanistic insights have important clinical implications. PMID: 27065322
    5. Examined eoffect of Emi1 over-expression on Skp2 expression in breast cancer. Found expression of Emi1 was positively related with Skp2 expression; Emi1 expression correlated significantly with histologic grade. Skp2 expression obtained similar results. PMID: 24277465
    6. Human papillomavirus type 16 E7 expression causes increased EMI1 mRNA expression and also inhibits EMI1 degradation. PMID: 24074588
    7. The C-terminal domain inhibits multiple APC/C(CDH1) functions. The intrinsically disordered D-box, linker & tail elements, & a structured Zn-binding domain synergistically block the substrate-binding site & inhibit ubiquitin-chain elongation. PMID: 23708605
    8. Emi1 depletion enhances the sensitivity of cancer cells to doxorubicin and x-ray irradiation. PMID: 23645673
    9. Emi1 expression (>5%) was seen in 23.3% of ovarian clear cell carcinoma, and associated with high FIGO grades and poor overall survival PMID: 23202783
    10. Emi1 participates in human hepatocellular carcinoma (HCC) cell proliferation and that progression is controlled by anaphase-promoting complex/cyclosome (APC/C) inhibition, which stabilized Skp2 and enabled p27(kip1) degradation. PMID: 22995332
    11. the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs PMID: 21454540
    12. Results suggest that Bcr-Abl increases Emi1 phosphorylation and stability to prevent Skp2 protein degradation via APC/Cdh1-induced ubiquitination and to enhance proliferation of CML cells. PMID: 20717963
    13. These data suggest that E2F can activate both transcription of cyclin A and the hEmi1-dependent stabilization of APC(Cdh1) targets, such as cyclin A, to promote S phase entry. PMID: 11988738
    14. Plk1 activates the anaphase promoting complex by directing the SCF-dependent destruction of Emi1 in prophase PMID: 15469984
    15. loss of pRb repression of E2F-mediated transcription causing misregulation of Emi1 and APC/C substrates results in the generation of tetraploidy and proliferation of genomically unstable cells in the absence of normal p53 function PMID: 16861914
    16. Emi1 associates in a complex with the anaphase-promoting complex/cyclosome (APC/C) and Cdh1; Emi1 binds to the APC/C via a conserved C-terminal destruction (D)-box and can compete for APC/C-substrate interaction. PMID: 16921029
    17. bservations reveal a novel mechanism for the control of entry into the first meiotic division: an Emi1-dependent inhibition of APC(Cdh1). PMID: 17190794
    18. These data suggest that Emi1 plays a critical role in preserving genome integrity by blocking rereplication, revealing a previously unrecognized function of this inhibitor of anaphase-promoting complex/cyclosome. PMID: 17234884
    19. Emi1 plays a crucial role in the cell cycle to couple DNA replication with mitosis PMID: 17485488
    20. critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis PMID: 17609108
    21. We investigated Emi1 protein expression in ovarian neoplasms PMID: 18204430
    22. Emi1 down-regulation and APC activation leads to stable p21-dependent G2 arrest after DNA damage. PMID: 19211842
    23. Results underscore the crucial role of cyclin A2-CDK2 in regulating the PLK1-SCF(beta-TrCP1)-EMI1-APC/C axis and CDC6 to trigger genome reduplication after the activity of CDK1 is suppressed. PMID: 19822658

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13584

    OMIM: 606013

    KEGG: hsa:26271

    STRING: 9606.ENSP00000229758

    UniGene: Hs.520506



主站蜘蛛池模板: 理论片午午伦夜理片影院| 中文字幕人妻熟女在线| 欧美精品高清在线观看| 久久国产劲暴∨内射新川| 青青青国产在线观看资源| 亚洲精品图片区小说区| 少妇激情一区二区三区视频小说| 无码av天堂一区二区三区| 欧美国产激情一区二区在线 | 久久影院午夜伦手机不四虎卡| 蜜臀国产在线视频| 永久免费的av在线电影网无码| 中文在线а天堂| 亚洲腹肌男啪啪网站男同| 久热国产精品视频一区二区三区 | 无码国产精品免费看| 裸体女人高潮毛片| 久久久久人妻一区精品性色av| 国产精品免费一区二区三区四区| 亚洲精品人成网线在线播放va| 丰满又黄又爽少妇毛片| 日本高清成本人视频一区| 亚洲 欧美 国产 日韩 中文字幕| 全部av―极品视觉盛宴| 午夜爱爱免费视频体验区| 欧美日韩无线码在线观看| 西欧free性满足hd老熟妇| 亚洲va久久久噜噜噜久久4399 | 亚洲欧美日韩成人一区二区三区| 中文字幕乱码免费专区| 东北老女人高潮大叫对白| 狠狠色综合网站久久久久久久高清| 色多多成视频人在线观看| 国产偷国产偷亚洲清高网站| 中文字幕无码免费久久99| 精品一区二区三区免费毛片爱| 四虎影视精品永久在线观看| av无码国产在线看免费网站 | 亚洲亚洲熟妇色l图片20p| 在线观看免费视频网站a站| 夫妇交换性三中文字幕|