在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FANCM Antibody

  • 中文名稱:
    FANCM兔多克隆抗體
  • 貨號:
    CSB-PA810301ESR1HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FANCM Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FANCM
  • 別名:
    FANCM antibody; KIAA1596Fanconi anemia group M protein antibody; Protein FACM antibody; EC 3.6.4.13 antibody; ATP-dependent RNA helicase FANCM antibody; Fanconi anemia-associated polypeptide of 250 kDa antibody; FAAP250 antibody; Protein Hef ortholog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Fanconi anemia group M protein (390-660AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
  • 基因功能參考文獻:
    1. Our study of the Polish and Ukrainian populations has identified a carrier frequency of truncating mutations in FANCM and breast cancer susceptibility. PMID: 29351780
    2. FANCM expression is a prognostic factor for overall survival in luminal B breast cancer in Chinese patients. PMID: 29388117
    3. Loss-of-function mutations in FANCM cause a cancer predisposition syndrome clinically distinct from bona fide FA. Care should be taken with chemotherapy and radiation treatments in these patients due to expected acute toxicity. PMID: 28837157
    4. Our data indicate that biallelic FANCM mutations do not cause classical FA, providing proof that FANCM is not a canonical FA gene. FANCM is a breast cancer-predisposing gene. Mutation testing of FANCM might be considered for individuals with the above-described clinical features. PMID: 28837162
    5. Two FANCM truncating mutations, the c.1432C>T (p.Arg478Ter) and c.1972C>T (p.Arg658Ter), were identified in two Male Breast Cancer cases (0.7%). When specifically considering cases at increased genetic risk for BC, FANCM mutation frequency raises up to 1%. Rare FANCM truncating mutations, other than c.5101C>T and c.5791C>T, may have a role in MBC susceptibility. PMID: 29287190
    6. Mutation in FANCM gene is associated with non-syndromic primary ovarian insufficiency. PMID: 29231814
    7. These results support the role of FANCM as a breast cancer susceptibility gene, particularly for triple-negative breast cancer. PMID: 28702895
    8. FANCM is actively recruited to the alternative lengthening of telomeres that are experiencing replication stress. PMID: 28673972
    9. we demonstrated that FANCM is a direct target of miR146a PMID: 27351285
    10. This case-control study included 2047 BRCA1 and BRCA2-negative familial breast cancer cases and 2187 controls and revealed an association of FANCM mutations with breast cancer. More pronounced associations were identified for early-onset (before age 51 years) breast cancer and triple-negative breast cancer. PMID: 28033443
    11. FANCM c.5101C > T nonsense mutation carriers have a reduced breast cancer survival but postoperative radiotherapy may diminish this survival disadvantage. PMID: 27542569
    12. we provide evidence for the first time showing that the common p.Arg1931* loss-of-function variant in FANCM is a risk factor for familial breast cancer. PMID: 26130695
    13. FANCM c.5101C>T mutation was not identified in Pakistani triple-negative breast cancer patients PMID: 26067930
    14. MHF facilitates the processing of multiple types of branched DNAs by the DNA translocase FANCM. MHF complex recognizes branched DNA and stimulates FANCM activity at such a structure to promote genome maintenance. PMID: 24390579
    15. FANCM is a breast cancer susceptibility gene, mutations in which confer a particularly strong predisposition for triple-negative breast cancer PMID: 25288723
    16. The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA. PMID: 24699063
    17. The FANCM translocase domain lies in proximity to C-terminal domain and binding fork DNA structures stimulate its ATPase activity. PMID: 23932590
    18. The traverse frequency was strongly reduced by inactivation of the translocase and DNA binding activities of the FANCM/MHF complex. PMID: 24207054
    19. Variations of several key residues and the electrostatic property at the active-site region render a catalytically inactive nuclease domain of FANCM, accounting for the lack of nuclease activity. PMID: 24003026
    20. Genotoxic stress-induced FANCM phosphorylation is ATR-dependent. PMID: 23698467
    21. FANCM participates in recombination-independent interstrand crosslink repair by facilitating recruitment of lesion incision activities, which requires its translocase activity PMID: 23333308
    22. we genetically characterized a conserved yeast ICL repair pathway composed of the yeast homologs (Mph1, Chl1, Mhf1, Mhf2) of four FA proteins (FANCM, FANCJ, MHF1, MHF2 PMID: 22696213
    23. cells expressing translocase-defective FANCM show altered global replication dynamics due to increased accumulation of stalled forks that subsequently degenerate into DNA double-strand breaks, leading to ATM activation and homologous recombination repair PMID: 22279085
    24. MHF1 and MHF2 form a compact tetramer to which FANCM-F binds through a 'dual-V' shaped structure. PMID: 22510687
    25. analysis of the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome PMID: 22392978
    26. human MutS homologs and FANCM complexes function as redundant DNA damage sensors of the Fanconi Anemia pathway PMID: 21975120
    27. FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks. PMID: 20670894
    28. show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. PMID: 20347428
    29. provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM. PMID: 20347429
    30. signalling through the checkpoint effector kinase Chk1 prevents FANCM from degradation by the proteasome after exposure to DNA damage PMID: 20010692
    31. FANCM (mutated in the human cancer predisposition syndrome, Fanconi's anaemia (FA)) co-ordinately regulates checkpoint signalling and replication fork progression. PMID: 20160754
    32. Data show that FANCM links Fanconi anemia and Bloom's syndrome by acting as a protein anchor and bridge that targets key components of the FA and BS pathways to stalled replication forks, linking components that are necessary for DNA repair. PMID: 20064461
    33. FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity PMID: 18174376
    34. FANCM specifically binds to Holliday junctions & replication forks & promotes ATPase-dependent migration of their junction point. It dissociates large recombination intermediates by branch migration of Holliday junctions through 2.6 kb of DNA. PMID: 18206976
    35. These data are consistent with participation of FANCM and its associated FA core complex in the FA pathway at both signaling through monoubiquitination and the ensuing DNA repair. PMID: 18285517
    36. DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia. PMID: 18995830
    37. FANCM is hyperphosphorylated and degraded during mitosis and beta-transducin repeat-containing protein and Polo-like kinase 1 are the key regulators of FANCM degradation. PMID: 19270156
    38. unlike cells defective in other core complex members, FANCM(-/-) cells were proficient in monoubiquitinating FANCD2 PMID: 19423727
    39. results rule out a major role of FANCM in familial breast cancer susceptibility PMID: 19737859

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    DEAD box helicase family, DEAH subfamily, FANCM sub-subfamily
  • 組織特異性:
    Expressed in germ cells of fetal and adult ovaries. In fetal ovaries, it is present in oogonia but expression is stronger in pachytene stage oocytes. Expressed in oocytes arrested at the diplotene stage of prophase I during the last trimester of pregnancy
  • 數據庫鏈接:

    HGNC: 23168

    OMIM: 609644

    KEGG: hsa:57697

    STRING: 9606.ENSP00000267430

    UniGene: Hs.509229



主站蜘蛛池模板: 2019久久视频这里有精品15| √天堂中文www官网在线| 躁躁躁日日躁| 99热这里只有精品最新地址获取| 免费人成网站在线观看欧美| a狠狠久久蜜臀婷色中文网| 久久亚洲欧美国产精品| 亚洲免费观看视频| 午夜精品一区二区三区的区别| 色一情一区二| 久久97久久97精品免视看秋霞| 亚洲v欧美v日韩v国产v| 亚洲午夜福利在线视频| 99re6在线视频精品免费下载| 国产高清狼人香蕉在线| 色偷偷尼玛图亚洲综合| 国产精成人品日日拍夜夜| 男人用嘴添女人下身免费视频| 狠狠躁夜夜躁人人爽天天天天97| 西西人体大胆4444www| 成人亚洲欧美日韩在线观看| 正在播放国产剧情亂倫| 国产奶头好大揉着好爽视频| 日韩毛片在线视频x| 国产香蕉国产精品偷在线| 色老头精品午夜福利视频| 都市激综合小说区另类区| 色狠狠av老熟女| 久久精品中文字幕一区二区三区 | 国产又爽又黄又刺激的视频| 亚洲人成人无码www影院 | 国产精品乱子伦xxxx裸| 7777奇米成人狠狠成人影视| 天堂网在线观看| 少妇下面好紧好多水真爽播放| 亚洲伊人久久大香线蕉综合图片| 国内精品久久久久影院网站| 手机真实国产乱子伦对白视频| 国产一性一交一伦一a片| 性夜夜春夜夜爽aa片a| 人妻人人澡人人添人人爽人人玩|