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FAM3C Antibody

  • 中文名稱:
    FAM3C兔多克隆抗體
  • 貨號:
    CSB-PA856401LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: FAM3C antibody at 4µg/ml + A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25 kDa
      Observed band size: 25 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FAM3C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FAM3C
  • 別名:
    Fam3c antibody; FAM3C_HUMAN antibody; Family with sequence similarity 3 member C antibody; GS3786 antibody; ILEI antibody; Interleukin-like EMT inducer antibody; Predicted osteoblast protein antibody; Protein FAM3C antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein FAM3C protein (31-227AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,FAM3C Antibody (CSB-PA856401LA01HU),的標記方式是Non-conjugated。對于FAM3C Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA856401LB01HU FAM3C Antibody, HRP conjugated ELISA
    FITC CSB-PA856401LC01HU FAM3C Antibody, FITC conjugated
    Biotin CSB-PA856401LD01HU FAM3C Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
  • 基因功能參考文獻:
    1. The ILEI appears to play a crucial role in mediating TGF-beta1-induced EMT through the Akt and ERK pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases. PMID: 29336056
    2. Covalent dimerization of ILEI is associated with breast cancer metastasis. PMID: 28837266
    3. Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness. PMID: 28751379
    4. Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF-low melanoma cell lines. PMID: 28545079
    5. Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells PMID: 27862841
    6. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. PMID: 27256505
    7. FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery PMID: 26498278
    8. Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR protein expression. PMID: 25212966
    9. Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer. PMID: 24738665
    10. ILEI could induce, as well as maintain, CD24(low)CD44(high) subpopulation in A549 cells treated with TGF-beta, which might explain its capability to induce metastatic progression. PMID: 24072492
    11. At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD. PMID: 22159821
    12. A cytokine-like protein found in almost all tissues. PMID: 12160727
    13. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors. PMID: 16959614
    14. Data show that FAM3C is decreased in the CSF of temporal lobe epilepsy patients. PMID: 19109932

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  • 亞細胞定位:
    Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.
  • 蛋白家族:
    FAM3 family
  • 組織特異性:
    Present in most secretory epithelia (at protein level).
  • 數據庫鏈接:

    HGNC: 18664

    OMIM: 608618

    KEGG: hsa:10447

    STRING: 9606.ENSP00000353025

    UniGene: Hs.272375



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