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FAM3B Antibody

  • 中文名稱:
    FAM3B兔多克隆抗體
  • 貨號:
    CSB-PA008227LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA008227LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Rat brain tissue, Mouse brain tissue
      All lanes: FAM3B antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26, 31, 21 kDa
      Observed band size: 26 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FAM3B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    2-21 antibody; C21orf11 antibody; C21orf76 antibody; Cytokine like protein 2 21 antibody; Cytokine-like protein 2-21 antibody; Fam3b antibody; FAM3B_HUMAN antibody; Family with sequence similarity 3 member B antibody; ORF9 antibody; Pancreatic-derived factor antibody; PANDER antibody; PRED44 antibody; Protein FAM3B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Protein FAM3B protein (31-235AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,FAM3B Antibody (CSB-PA008227LA01HU),的標記方式是Non-conjugated。對于FAM3B Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA008227LB01HU FAM3B Antibody, HRP conjugated ELISA
    FITC CSB-PA008227LC01HU FAM3B Antibody, FITC conjugated
    Biotin CSB-PA008227LD01HU FAM3B Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
  • 基因功能參考文獻:
    1. Taken together, by activating pro-survival mechanisms FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice, highlighting a putative role for this cytokine in prostate cancer progression. PMID: 29357840
    2. FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice. PMID: 29357840
    3. Data suggest that serum PANDER levels are significantly elevated in patients with long-standing type 2 diabetes as compared to patients with recently diagnosed type 2 diabetes and control subjects; serum PANDER levels vary according to degree of insulin resistance. PMID: 28161382
    4. Circulating level of pancreatic-derived factor (PANDER) in relation to the accumulation in metabolic syndrome suggested that persons with elevated levels of PANDER were associated with an increased risk of metabolic syndrome. PMID: 27181109
    5. in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP. PMID: 26123584
    6. beta-cell-secreted PANDER regulated the hepatic insulin and lipogenenic signaling and impact overall glycemia. PMID: 24468680
    7. It is an important regulator of glucose and lipid metabolism and plays a role in the pathogenesis of nonalcoholic fatty liver disease.(review) PMID: 23855304
    8. our studies demonstrated that silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death. PMID: 23246487
    9. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug. PMID: 23059759
    10. Localized to the islets of Langerhans. PMID: 12160727
    11. Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death. PMID: 16114871
    12. PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin, and structure and conformation is vital for PANDER secretion. PMID: 16249448

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  • 亞細胞定位:
    Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
  • 蛋白家族:
    FAM3 family
  • 組織特異性:
    Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
  • 數據庫鏈接:

    HGNC: 1253

    OMIM: 608617

    KEGG: hsa:54097

    STRING: 9606.ENSP00000350673

    UniGene: Hs.473877



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