在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FAIM2 Antibody

  • 中文名稱:
    FAIM2兔多克隆抗體
  • 貨號:
    CSB-PA866298DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA866298DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA866298DSR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FAIM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FAIM2
  • 別名:
    FAIM2; KIAA0950; LFG; LFG2; NMP35; TMBIM2; Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein lifeguard 2 protein (1-105AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
  • 基因功能參考文獻:
    1. results suggest that high level miR-3202 in T lymphocytes may protect epithelial cells through targeting FAIM2. MiR-3202 might be used as a notable biomarker of chronic obstructive pulmonary disease . PMID: 29208459
    2. that miR-193b is indispensible for the competitive endogenous RNA role of SNHG7 in FAIM2-supported tumourigenesis of lung cancer PMID: 29131440
    3. FAIM2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    4. our research showed that lncRNA-SNHG7 promotes the proliferation, migration and invasion, and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression, suggesting that lncRNA-SNHG7 as a key regulator of gene expression, may be a promising therapeutic strategy for the treatment of lung cancer PMID: 27666964
    5. The interaction of TRIM21 and LFG was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out. PMID: 26398169
    6. There are significant differences in the associations of the FAIM2 promoter methylation with sedentary behaviour and physical activity between obese and lean children. PMID: 25922107
    7. Methylation levels of the FAIM2 promoter are significantly associated with obesity and are independently associated with dyslipidaemia and its components in Chinese children. PMID: 25696115
    8. Low KRT13 mRNA expression is associated with oral squamous cell carcinoma. PMID: 25735388
    9. These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues PMID: 25764978
    10. Results indicated that FAIM2 beta-isoform is strongly expressed in breast tumour tissues. Fas sensitivity was reduced in the MCF10A breast cells expressing the FAIM2 beta-isoform. PMID: 25069766
    11. This study highlighted the importance of two candidate genes, SH2B1 and FAIM2, in the risk of overweight/obesity. PMID: 24621099
    12. A polymorphism in FAIM2 is associated with higher myocardial infarction risk in type-2 diabetes mellitus subjects. PMID: 24393375
    13. The rs7138803 variant of FAIM2 was found to exert no effect on obesity in a Chinese Han population. PMID: 23924573
    14. Faim2 is physiologically expressed in brain in bacterial meningitis. PMID: 24335530
    15. Analysis identified SNPs at three loci known to be associated with BMI with genome-wide confidence (P<5x10(-8); FTO, MC4R and FAIM2). PMID: 21935397
    16. LFG is required for proper development and survival of granular and Purkinje cells and LFG may play a role in cerebellar disorders PMID: 21957071
    17. LFG is strongly expressed in breast cancer epithelial cells. Moreover, the overexpression of LFG correlated with tumour grade and reduced Fas sensitivity. PMID: 20336406
    18. Data show that SNPs in SEC16B and TMEM18 were significantly associated with obesity, and the SNPs in GNPDA2, BDNF, FAIM2 and MC4R were marginally associated with obesity in Japanese. PMID: 19851340
    19. Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection. PMID: 17912957
    20. The tmbim2 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments PMID: 18440869

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族:
    BI1 family, LFG subfamily
  • 組織特異性:
    Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampu
  • 數據庫鏈接:

    HGNC: 17067

    OMIM: 604306

    KEGG: hsa:23017

    STRING: 9606.ENSP00000321951

    UniGene: Hs.567424



主站蜘蛛池模板: 色爱区综合五月激情| 无码一区18禁3d| 亚洲久久中文字幕www网站| 日韩精品人妻系列一区二区三区| 欧美性性性性o00xx| 在线亚洲专区高清中文字幕| 国产精品高清网站| 亚洲 高清 成人 动漫| 国精产品999国精产| 国产精品无码日韩欧| 三级理论中文字幕在线播放| 久久99精品久久久久久蜜芽| 欧美性大战久久久久xxx| 成人综合伊人五月婷久久| 欧美深性狂猛ⅹxxx深喉| 人妻人人澡人人添人人爽人人玩| 成·人免费午夜无码视频蜜芽| 99久久精品国产免费| 亚洲色欲色欱www在线| 国产精品96久久久久久| 亚洲综合色噜噜狠狠网站超清| 国产亚洲人成无码网在线观看| 特级做a爰片毛片免费看| 国自产拍偷拍精品啪啪一区二区| 国产亚洲精品a在线| 97色伦97色伦国产欧美| 欧美日韩国产综合新一区| 狠狠色噜噜狠狠狠7777奇米| 美女内射视频www网站午夜| 狠狠躁夜夜躁人人爽天天古典| 国内自拍久久久久影院| 男男车车的车车网站w98免费| 老子午夜精品无码不卡 | 亚洲无线码一区二区三区| 18禁无遮挡啪啪无码网站| 国产自产v一区二区三区c| 欧美人与禽猛交狂配| 亚洲国产精品久久久天堂不卡海量| 国产午夜永久福利视频在线观看 | 免费人成在线观看视频播放| 又黄又爽又高潮免费毛片|