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  4. FAF2 Antibody

FAF2 Antibody

  • 中文名稱：
    FAF2兔多克隆抗體
  • 貨號：
    CSB-PA007964GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FAF2
  • 別名：
    AI462440 antibody; expressed in T cells and eosinophils in atopic dermatitis antibody; faf2 antibody; FAF2_HUMAN antibody; Fas associated factor family member 2 antibody; FAS-associated factor 2 antibody; KIAA0887 antibody; Protein ETEA antibody; Protein expressed in T cells and eosinophils in atopic dermatitis antibody; Protein expressed in T-cells and eosinophils in atopic dermatitis antibody; UBX domain containing 8 antibody; UBX domain protein 3B antibody; UBX domain-containing protein 3B antibody; UBX domain-containing protein 8 antibody; UBXD8 antibody; UBXN3B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FAF2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
  • 基因功能參考文獻：
    1. We present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. Mechanistic studies demonstrate that UBXN3B interacts with both STING and its E3 ligase TRIM56, and facilitates STING ubiquitination, dimerization, trafficking, and consequent recruitment and phosphorylation of TBK1. PMID: 29899553
    2. UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain. PMID: 28882874
    3. that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis PMID: 27295553
    4. role of UBXD8 in cellular responses to excess fatty acids PMID: 24378746
    5. the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids PMID: 23720822
    6. UBXD8-mediated recruitment of p97/VCP to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis. PMID: 23297223
    7. Ubx2 and Ubxd8 regulates lipid droplet homeostasis. PMID: 22454508
    8. These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively. PMID: 22238364
    9. These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids. PMID: 21115839
    10. These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans). PMID: 20160012
    11. ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients PMID: 12372427

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  • 亞細胞定位：
    Cytoplasm. Lipid droplet. Endoplasmic reticulum.
  • 組織特異性：
    Broadly expressed, with highest levels in brain.
  • 數據庫鏈接：

    HGNC: 24666

    OMIM: 616935

    KEGG: hsa:23197

    STRING: 9606.ENSP00000261942

    UniGene: Hs.484242



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