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  4. FAAP20 Antibody, FITC conjugated

FAAP20 Antibody, FITC conjugated

  • 中文名稱：
    FAAP20兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA750774HC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FAAP20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FAAP20
  • 別名：
    C1orf86 antibody; CA086_HUMAN antibody; Chromosome 1 open reading frame 86 antibody; FAAP20 antibody; Fanconi anemia associated protein of 20 kDa antibody; FP7162 antibody; RP11-181G12.3 antibody; Uncharacterized protein C1orf86 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Fanconi anemia core complex-associated protein 20 protein (14-179AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
  • 基因功能參考文獻：
    1. Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20). PMID: 26318859
    2. FAAP20 contains a conserved ubiquitin-binding zinc-finger domain and binds K-63-linked ubiquitin chains in vitro. The FAAP20-UBZ domain is not required for interaction with FANCA, but is required for DNA-damage-induced chromatin loading of FANCA and the functional integrity of the Fanconi anemia pathway. PMID: 22343915
    3. FAAP20-ubiquitin interaction expands beyond the compact UBZ domain and requires the folding and interaction of the otherwise disordered C-terminal tail of FAAP20 for high-affinity binding. PMID: 25414354
    4. Data indicate that RNF8 and FAAP20 (C1orf86) are needed for efficient Fanconi anemia group D2 protein FANCD2 monoubiquitination. PMID: 22705371
    5. FAAP20 is an important player involved in the Fanconi anemia pathway PMID: 22396592

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  • 亞細胞定位：
    Nucleus. Chromosome.
  • 數據庫鏈接：

    HGNC: 26428

    OMIM: 615183

    KEGG: hsa:199990

    STRING: 9606.ENSP00000367808

    UniGene: Hs.107101



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