在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EXT2 Antibody, Biotin conjugated

  • 中文名稱:
    EXT2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA849974LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) EXT2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EXT2
  • 別名:
    Exostoses (multiple) 2 antibody; Exostosin 2 antibody; Exostosin-2 antibody; EXT2 antibody; EXT2_HUMAN antibody; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase antibody; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody; Multiple exostoses protein 2 antibody; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase antibody; Putative tumor suppressor protein EXT2 antibody; SOTV antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Exostosin-2 protein (180-267AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan.
  • 基因功能參考文獻(xiàn):
    1. Let-7b-mediated suppression of initiation codon depends on the length of 5'-UTR of EXT2 mRNA and its suppression is inhibited in the presence of polyamines. PMID: 27650265
    2. the present study identified a novel missense mutation (c.1385G>A) in exon 8 and a splicing mutation (c.725+1G>C) in intron 3 of the EXT2 gene, which are responsible for MO in certain Chinese patients. The findings are useful for expanding the database of known EXT2 mutations and understanding the genetic basis of MO in Chinese patients, which may improve genetic counseling and the prenatal diagnosis of MO. PMID: 28849184
    3. Germline EXT2 mutation is associated with chondrosarcoma. PMID: 27636706
    4. The mutation results in deletion of exon 5 in the mRNA, producing a frameshift that leads to a premature termination codon. The present study extends the mutational spectrum of EXT2. PMID: 27748933
    5. Authors identified two homozygous mutations p.Met87Arg and p.Arg95 Cys in exostosin 2, EXT2, a ubiquitously expressed gene that encodes a glycosyltransferase. In patient cells, diminished expression and function was observed. PMID: 26246518
    6. EXT2 gene might not have a major role in the development of type 2 diabetes in the Chinese population. PMID: 25207843
    7. EXT2 mutation is associated with multiple osteochondromatosis. PMID: 25230886
    8. loss of function of EXT2 subjects with hereditary multiple exostoses affects pancreatic insulin secretion capacity and development. PMID: 25541963
    9. Analysis of microsatellite polymorphic markers in the 11p region harboring the EXT2 gene did not reveal any loss of heterozygosity PMID: 25744876
    10. The heterozygous mutation c.743+1G>A in the EXT2 gene causes HME as a result of abnormal splicing, mRNA decay, and the resulting haploinsufficiency of EXT2. PMID: 24728384
    11. The second exon of EXT2. A c.244delG mutation is associated with hereditary multiple exostosis. PMID: 25449079
    12. This study demonstrated no association of rs1113132, rs3740878 and rs11037909 EXT2 variants with type 2 diabetes mellitus. PMID: 23871501
    13. A meta analysis indicates variation in the EXT2 locus appears to be associated with a small increase in the risk of type 2 diabetes. PMID: 23052945
    14. Association of genetic variations in EXT2 with Type 2 diabetes mellitus in Tunisia PMID: 21510814
    15. Loss of heterozygosity for EXT2 is associated with multiple osteochondromas. PMID: 20813973
    16. primary defect in EXT2 mRNA level can produce profound effect on the synthesis of HS chains in cartilage, the consequence of which impacts on the regulation of chondrocyte proliferation and differentiation. PMID: 20872591
    17. The nonsens mutation 536G>A in the EXT2 is the disease-causing mutation in a family with hereditary multiple exostoses. PMID: 20140877
    18. the EXT1/2 heterocomplex can act as heparan sulfate polymerases in vitro without the addition of additional auxiliary proteins PMID: 12907669
    19. 112delAT causes multiple exostoses, indicating full penetrance since relatives with isolated exotoses lacked this deletion. PMID: 14654969
    20. Variations in EXT2 gene is associated with multiple osteochondromas PMID: 15586175
    21. Promoter methylation was not detected in any of the chondrosarcoma cases in EXT2. PMID: 15796962
    22. Detection of mutations in EXT2 gene can significantly improve the identification of both point-mutations and mid-size rearrangemements in osteochrondromas. PMID: 17301954
    23. Compared to EXT2-linkage, female individuals with EXT1-linkage were smaller in stature. PMID: 17676624
    24. A novel mutation, c505 G > T, in the EXT2 gene was identified in two unrelated Chinese families with hereditary multiple exostoses. PMID: 18294062
    25. A novel mutation in EXT2 gene in a Chinese family with hereditary exostoses is reported. PMID: 18666861
    26. Data show that SNPs in EXT2 did not confer a significant risk for type 2 diabetes in Pima Indians. PMID: 19008344
    27. The tumor suppressor gene EXT2 is involved in the formation of multiple osteochondromas, which can progress to become secondary peripheral chondrosarcomas. PMID: 19179614
    28. A previously unreported stop mutation, the substitution c.817C>T, was observed in the EXT2 gene in an Indian pedigree of hereditary multiple exostoses families. PMID: 19309273

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Hereditary multiple exostoses 2 (EXT2); Potocki-Shaffer syndrome (POSHS); Seizures, scoliosis, and macrocephaly syndrome (SSMS)
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
  • 蛋白家族:
    Glycosyltransferase 47 family
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3513

    OMIM: 133701

    KEGG: hsa:2132

    STRING: 9606.ENSP00000379032

    UniGene: Hs.368404



主站蜘蛛池模板: 国产亚洲精品久久yy50| 国产人成网线在线播放va| 伊人精品成人久久综合| 在线看午夜福利片国产| 亚洲色精品三区二区一区| 成人午夜精品无码区久久| 国产免费久久久久久无码| 香蕉在线精品视频在线| 国产精品美女久久久网站动漫| 又粗又硬又黄又爽的视频永久| 国产亚洲综合区成人国产系列| 国产精品久久久午夜夜伦鲁鲁| 鲁一鲁一鲁一鲁一澡| 忍着娇喘人妻被中出中文字幕 | 中文字幕无码一区二区免费| 国产av人人夜夜澡人人爽| 国产丝袜在线精品丝袜不卡| 亚洲日韩精品国产一区二区三区| 热99re久久精品这里都是精品| 国产午夜成人av在线播放| 新区乱码无人区二精东| 久久久亚洲精品av无码| 亚洲成av人片在线观看无| 欧美疯狂性受xxxxx另类| 自拍偷在线精品自拍偷99| 国产成人国拍亚洲精品| 亚洲综合久久一本伊一区| 精品无人国产偷自产在线| 国产97色在线 | 国产| 久久综合少妇11p| 亚洲成av人影院无码不卡| 日韩人妻一区二区三区蜜桃视频| 午夜精品久久久久久久久久久久| 人妻熟女av一区二区三区| 嫩草研究院久久久精品| 久久久久成人精品免费播放动漫| 高潮内射免费看片| 人人妻碰人人免费| 日本欧美一区二区三区乱码| 99这里只有精品| 无遮挡午夜男女xx00动态|