在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EXOSC5 Antibody, FITC conjugated

  • 中文名稱:
    EXOSC5兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA878857LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EXOSC5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Chronic myelogenous leukemia tumor antigen 28 antibody; CML28 antibody; EXOS5_HUMAN antibody; EXOSC 5 antibody; Exosc5 antibody; Exosome complex component rrp46 antibody; exosome complex exonuclease RRP46 antibody; Exosome component 5 antibody; exosome component Rrp46 antibody; hRrp46p antibody; p12B antibody; Ribosomal RNA processing protein 46 antibody; Ribosomal RNA processing protein 46, S. cerevisiae, homolog of antibody; Ribosomal RNA-processing protein 46 antibody; RRP41B antibody; RRP46 antibody; Rrp46p antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Exosome complex component RRP46 protein (1-235AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
  • 基因功能參考文獻:
    1. Further, subcellular co-localization assay showed that the two proteins could co-localize in the cytoplasm of K562 cells, but WT1/CML28 complexes were not detected by using immunoprecipitation. PMID: 23392705
    2. Results suggest that Rrp46 forms a homodimer separately from exosome complexes and, depending on species, is a structural component of the machinery that cleaves DNA during apoptosis. PMID: 20660080
    3. association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p PMID: 11812149
    4. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs. PMID: 16815301
    5. rAAV/CML28-transduced DCs vaccine may serve as a feasible approach for the treatment of CML28-associated cancers. PMID: 18157497

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Cytoplasm. Nucleus.
  • 蛋白家族:
    RNase PH family
  • 組織特異性:
    Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
  • 數據庫鏈接:

    HGNC: 24662

    OMIM: 606492

    KEGG: hsa:56915

    STRING: 9606.ENSP00000221233

    UniGene: Hs.283741



主站蜘蛛池模板: 无码帝国www无码专区色综合| 精品国产经典三级在线看| 欧美肥老太牲交| 国产成人精品午夜福利不卡 | 日产精品一卡2卡三卡4乱码| 在线观看特色大片免费视频 | 男女无遮挡xx00动态图120秒| 久久大香香蕉国产| 久久午夜夜伦鲁鲁片免费无码影视| 香港曰本韩国三级网站| 欧美性白人极品1819hd| 在教室伦流澡到高潮hgl视频| 精品久久久久久国产| 国产三级不卡在线观看视频| 又黄又湿免费高清视频| 久久成人国产精品| 天天噜日日噜狠狠噜免费| 草草久久97超级碰碰碰| 一本大道大臿蕉视频无码| 国内精品人妻无码久久久影院蜜桃| 好吊妞无缓冲视频观看| 一本色道久久综合亚州精品蜜桃| 国产曰批免费视频播放免费| 色偷偷亚洲男人本色| 亚洲妇女水蜜桃av网网站| 国产无遮挡免费真人视频在线观看| 国产精品无码久久久久久| 亚洲中文字幕无码爆乳app| 青青草国产线观看| 2020精品国产户外| 国产女人被狂躁到高潮小说 | 在教室伦流澡到高潮hgl动漫| 动漫无遮挡h纯肉亚洲资源大片| 狠狠的干性视频| 国内精品九九久久久精品| 一边摸一边叫床一边爽av| 日韩精品一区二区午夜成人版| 色综合色综合久久综合频道88| 在线观看国产午夜福利片| 精品一区二区三区无码av久久| 色欲麻豆国产福利精品|