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  4. EXOG Antibody

EXOG Antibody

  • 中文名稱：
    EXOG兔多克隆抗體
  • 貨號：
    CSB-PA002341
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using Endo G-L1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    EXOG
  • 別名：
    Endo G like 1 antibody; Endo G-like 1 antibody; Endo/exonuclease (5'-3'); endonuclease G like antibody; ENDOGL 1 antibody; ENDOGL1 antibody; ENDOGL2 antibody; Endonuclease G like 1 antibody; Endonuclease G like 2 antibody; Endonuclease G-like 1 antibody; ENGL a antibody; ENGL antibody; ENGL B antibody; ENGLA antibody; ENGLB antibody; Exog antibody; EXOG_HUMAN antibody; MGC125944 antibody; MGC125945 antibody; mitochondrial antibody; Nuclease EXOG antibody; Nuclease EXOG mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Endo G-L1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
  • 基因功能參考文獻：
    1. Data suggest a role of exo/endonuclease G nuclease (hEXOG) in pathway for mitochondrial DNA repair. PMID: 28466855
    2. These data indicate that HSV-1 UL12.5 deploys cellular proteins, including ENDOG and EXOG, to destroy mtDNA and contribute to a growing body of literature highlighting roles for ENDOG and EXOG in mtDNA maintenance. PMID: 23986585
    3. EXOG depletion induces persistent SSBs in the mtDNA, enhances ROS levels, and causes apoptosis in normal cells but not in mt genome-deficient rho0 cells. PMID: 21768646
    4. ENDOGL1 is a candidate disease-susceptibility gene for type 2 diabetes in a Japanese population PMID: 17415550
    5. Human endonuclease G-like-1 is a dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity and further differs from EndoG in substrate specificity PMID: 18187503

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  • 亞細胞定位：
    Mitochondrion inner membrane.
  • 蛋白家族：
    DNA/RNA non-specific endonuclease family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 3347

    OMIM: 604051

    KEGG: hsa:9941

    STRING: 9606.ENSP00000287675

    UniGene: Hs.517897



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