在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ESPL1 Antibody

  • 中文名稱:
    ESPL1兔多克隆抗體
  • 貨號:
    CSB-PA621785LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of HepG2 cells using CSB-PA621785LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ESPL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Caspase like protein ESPL1 antibody; Caspase-like protein ESPL1 antibody; ESP 1 antibody; ESP1 antibody; ESPL 1 antibody; Espl1 antibody; ESPL1_HUMAN antibody; Extra spindle poles like 1 antibody; Extra spindle poles like 1 protein antibody; Extra spindle poles-like 1 protein antibody; FLJ46492 antibody; KIAA0165 antibody; Separase antibody; Separin antibody; Similar to fission yeast cut1and gene antibody; SSE antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Separin protein (1292-1495AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ESPL1 Antibody (CSB-PA621785LA01HU),的標記方式是Non-conjugated。對于ESPL1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA621785LB01HU ESPL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA621785LC01HU ESPL1 Antibody, FITC conjugated
    Biotin CSB-PA621785LD01HU ESPL1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
  • 基因功能參考文獻:
    1. Separase activity measurement may therefore be useful as a novel additional molecular marker for disease monitoring PMID: 29370237
    2. Studies identified and characterized the role of separase in mitosis, meiosis, non-canonical roles, its regulation, as a regulator of centriole disengagement, non proteolytic roles, diverse substrates, structural insights, and association of separase with cancer. [review] PMID: 27966791
    3. High ESP expression is associated with breast cancer. PMID: 28859055
    4. Proximity mapping of human separase has been presented. PMID: 27495871
    5. The assay was used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients. PMID: 26267133
    6. Recruitment and activation of separase at centrosomes are two distinct steps that do not require microtubules. PMID: 25299182
    7. Separase protein levels decrease and Separase proteolytic activity increases exclusively in b3a2 p210BCR-ABL-positive cell lines under Imatinib treatment. PMID: 26087013
    8. Separase is an oncogene whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies. PMID: 24792645
    9. High ESPL1 mRNA expression was associated with luminal B breast cancers. PMID: 25086634
    10. Data indicate that separase is subject to native-state cis/trans isomerization by peptidyl-prolyl-isomerase Pin1. PMID: 25921067
    11. By consecutively acting as a protease and a cdk1 inhibitor, separase coordinates two key processes to achieve simultaneous and abrupt separation of sister chromatids. PMID: 22814604
    12. Kendrin is a novel and crucial substrate for separase (ESPL1) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis. PMID: 22542101
    13. Plk1-mediated phosphorylation of Cdc6 promotes the interaction of Cdc6 and Cdk1, leading to the attenuation of Cdk1 activity, release of separase, and subsequent anaphase progression. PMID: 21041660
    14. Anaphase specific auto-cleavage of separase. PMID: 12297314
    15. Processing, localization, and requirement of separase for normal anaphase progression. PMID: 12672959
    16. Separase function is not restricted to anaphase initiation; its role in promoting loss of sister chromatid cohesion might be preferentially at arms but not centromeres. PMID: 16177575
    17. Protein phosphatase 2A and separase form a complex regulated by separase autocleavage PMID: 17604273
    18. Phosphorylation promotes complex formation indirectly, possibly by inducing a conformational change in full-length separase. PMID: 17974570
    19. The complete removal of cohesin from chromosome arms depends on separase. PMID: 18003702
    20. Separase has targets involved in regulation of G(2) to M progression after DNA damage in lung cancer cells. PMID: 18616699
    21. These results collectively suggest that Separase is an oncogene, whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 mutant background. PMID: 18728194
    22. Study reports that cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner. PMID: 19345191
    23. Separase might be an oncogene, whose overexpression induces tumorigenesis. Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human cancers. PMID: 19351757
    24. Plk1 and separase act at different times during M phase to license centrosome duplication, reminiscent of their roles in removing cohesin from chromosomes PMID: 19758559

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數據庫鏈接:

    HGNC: 16856

    OMIM: 604143

    KEGG: hsa:9700

    STRING: 9606.ENSP00000257934

    UniGene: Hs.153479



主站蜘蛛池模板: 成人国产欧美大片一区| 免费视频好湿好紧好大好爽| 色哟哟免费视频播放网站| 又粗又黄又猛又爽大片免费| 乱中年女人伦av三区| 国产精品无码久久久久| 鲁丝片一区二区三区毛片| 福利视频一二三在线观看| 国产乱码二卡3卡四卡| 日本丰满熟妇videossex8k| 无码一区二区三区av免费| 国产精品白丝久久av网站| av第一福利网站| 国产乱人伦真实精品视频| 夜夜躁日日躁狠狠久久av| 午夜精品久久久久久久久久久久| 永久黄网站色视频免费无下载| 国产福利在线永久视频| 藏春阁福利视频| 日本丰满白嫩大屁股ass| 春药玩弄少妇高潮吼叫| 国产亚洲精aa在线观看| 乱人伦中文字幕成人网站在线| 成人网站免费大全日韩国产| 少妇扒开双腿让我看个够| 色五月丁香六月欧美综合| 日本最新免费二区三区| 久久婷婷综合激情亚洲狠狠| 欧洲丰满少妇a毛片| 亚洲综合久久一本久道| 午夜成人理论福利片| 在线不卡日本v一区二区| 体验区试看120秒啪啪免费| 色欲狠狠躁天天躁无码中文字幕| 国产精品久久久久久妇女6080| 寂寞骚妇被后入式爆草抓爆| 男人和女人高潮做爰视频| 国产亚洲精品成人aa片新蒲金 | 国内揄拍高清国内精品对白| 国产精品成人永久在线| 无码伊人66久久大杳蕉网站谷歌|