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  4. ERC1 Antibody

ERC1 Antibody

  • 中文名稱：
    ERC1兔多克隆抗體
  • 貨號：
    CSB-PA007767LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, COLO320 whole cell lysate, 293T whole cell lysate, U251 whole cell lysate
      All lanes: ERC1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 129, 114, 125, 109, 82 kDa
      Observed band size: 135 kDa
    • Immunofluorescence staining of U251 cells with CSB-PA007767LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ERC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cast 2 antibody; CAST2 antibody; CAZ associated structural protein 2 antibody; Elks antibody; ELKS/RAB6 interacting/CAST family member 1 antibody; ELKS/RAB6-interacting/CAST family member 1 antibody; ERC 1 antibody; ERC protein 1 antibody; ERC-1 antibody; Erc1 antibody; ERC1 protein antibody; KIAA1081 antibody; MGC12974 antibody; RAB6 interacting protein 2 antibody; RAB6-interacting protein 2 antibody; RAB6IP2 antibody; RB6I2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ELKS/Rab6-interacting/CAST family member 1 protein (1-224AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ERC1 Antibody (CSB-PA007767LA01HU)，的標記方式是Non-conjugated。對于ERC1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA007767LB01HU ERC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA007767LC01HU ERC1 Antibody, FITC conjugated
    Biotin CSB-PA007767LD01HU ERC1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • 基因功能參考文獻：
    1. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. PMID: 29348417
    2. ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming. PMID: 27253063
    3. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
    4. a new, but rare, antigen in Lambert-Eaton myasthenic syndrome PMID: 23583364
    5. ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-kappaB activation following genotoxic stimuli. PMID: 20932476
    6. Analysis of the gene structure of four isoforms (ELKS beta, ELKS gamma, ELKS delta, and ELKS epsilon) in a case of papillary thyroid carcinoma reveal that the isoforms are produced by alternative splicing. PMID: 12203787
    7. In vitro results indicate that ERC2/CAST, an active zone-specific isoform, interacts with all of the known isoforms of liprin-alpha and that liprin-alpha1 associates with both ERC2 and ERC1b PMID: 12923177
    8. ELKS likely functions by recruiting IkappaBalpha to the IkappaB kinase (IKK) complex and thus serves a regulatory function for IKK activation PMID: 15218148
    9. ERC1-PDGFRB fusion is associated with acute myeloid leukemia PMID: 17690697

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  • 相關疾病：
    A chromosomal aberration involving ERC1/RAB6IP2 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane.
  • 組織特異性：
    Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • 數據庫鏈接：

    HGNC: 17072

    OMIM: 607127

    KEGG: hsa:23085

    STRING: 9606.ENSP00000354158

    UniGene: Hs.601216



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