在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ERAP2 Antibody

ERAP2 Antibody

  • 中文名稱：
    ERAP2兔多克隆抗體
  • 貨號：
    CSB-PA007761LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA007761LA01HU diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ERAP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ERAP2
  • 別名：
    ERAP2 antibody; LRAPEndoplasmic reticulum aminopeptidase 2 antibody; EC 3.4.11.- antibody; Leukocyte-derived arginine aminopeptidase antibody; L-RAP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Endoplasmic reticulum aminopeptidase 2 protein (406-522AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ERAP2 Antibody (CSB-PA007761LA01HU)，的標(biāo)記方式是Non-conjugated。對于ERAP2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA007761LB01HU ERAP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007761LC01HU ERAP2 Antibody, FITC conjugated
    Biotin CSB-PA007761LD01HU ERAP2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
  • 基因功能參考文獻(xiàn)：
    1. this study shows the association of ERAP2 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset PMID: 29183862
    2. These results indicated that the ERAP gene may play a critical role in HCV chronicity in this Chinese Han population PMID: 29037997
    3. ERAP2 deficiency causes increased MHC class I free heavy chain expression and up-regulation of the unfolded protein response pathway in anklyosing spondylitis. PMID: 28029742
    4. ERAP-2 significantly influences the B*27:05-bound peptidome by destroying some ligands and decreasing the abundance of many more ligands with N-terminal basic residues, while increasing the abundance of nonamers. The former effects are best explained by direct ERAP-2 trimming. The effects on peptide length might be attributed to ERAP-2-induced activation of ERAP-1 trimming. These data support the notion of a peptide-media PMID: 27110896
    5. study reveals fine-mapped AID risk variants that act as eQTLs with ERAP2 in thymus PMID: 27829666
    6. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis. PMID: 27384923
    7. ERAP2 is associated with ankylosing spondylitis in HLA-B27 positive and HLA-B27 negative patients. PMID: 25917849
    8. ERAP2 might be associated with CLNM in PTMC. PMID: 26148615
    9. ERAP2 variation does not have a significant effect on PBMC intracellular and cell surface HLA-class I expression and heavy chain formation, markers of ER stress or inflammatory cytokine production. PMID: 26088389
    10. The risk allele of the polymorphism near ERAP2 is strongly associated with birdshot chorioretinopathy. PMID: 24957906
    11. ERAP2 haplotype A is correlated with resistance to HIV-1 infection, possibly secondarily to its effect on antigen processing and presentation. PMID: 23435305
    12. The association and co-localization of ERAP2 and EpCAM at the surface of breast cancer cells is a unique and novel finding that provides new ideas on EpCAM processing and on how antigen presentation may be regulated in cancer. PMID: 23988446
    13. Generation and destruction of antigenic peptides by endoplasmic reticulum resident aminopeptidases ERAP1 and ERAP2 have been shown in the last few years to be important for correct functioning and regulation of the adaptive immune response. PMID: 23545452
    14. The common ERAP2 single nucleotide polymorphism rs2549782 that codes for amino acid variation Asp392Lys leads to alterations in both the activity and the specificity of the enzyme. PMID: 22837489
    15. crystals of ERAP2 belonged to an orthorhombic space group and diffracted anisotropically to 3.3 A resolution in the best direction on an in-house X-ray source PMID: 22505422
    16. The molecular structure of glycosylated human ERAP2 has been determined to 3.08 A resolution by molecular replacement using ERAP1 as a search model and refined. PMID: 22106953
    17. assessed frequency of rs2248374 SNP in ERAP2 in ankylosing spondylitis (AS) cases and controls and found no association with AS PMID: 21719416
    18. strong evidence that ERAP2 plays a role in the development of preeclampsia PMID: 21569342
    19. ERAP2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
    20. Data show that the differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection. PMID: 20976248
    21. ERAP2, which encodes an aminopeptidase, did not show preferential parent-of-origin expression, but rather, cis-acting nonimprinted differential allelic control PMID: 18369178
    22. Novel preeclampsia risk locus, ERAP2, in a region of known genetic linkage to this pregnancy-specific disorder. PMID: 19578876
    23. Dramatic genetic effect on LRAP expression. PMID: 17129607

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase M1 family
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in spleen and leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29499

    OMIM: 609497

    KEGG: hsa:64167

    STRING: 9606.ENSP00000400376

    UniGene: Hs.482910



主站蜘蛛池模板： 中文字幕人妻a片免费看| 国产av一区二区三区传媒| 俄罗斯美女真人性做爰| 亚洲vav在线男人的天堂| 免费乱理伦片在线观看八戒| 国产9 9在线 | 欧洲| 欧美人与动人物牲交免费观看久久| 丁香五月激情综合色婷婷| 亚洲日韩va在线视频| 国产精品无码午夜免费影院| 凹凸国产熟女精品视频app| 日韩中文高清在线专区| 久久人人爽人人爽爽久久小说 | 亚洲伊人成综合网2222| 夜夜嗨av一区二区三区| 国产熟妇高潮呻吟喷水| 免费人成又黄又爽的视频| 免费人成小说在线观看网站| 在线视频免费观看爽爽爽| 久久精品熟女亚州av麻豆 | 无码成人片在线播放| 无遮18禁在线永久免费观看挡 | 国产精品久久久久久爽爽爽| 国产成人久久综合77777| 亚洲国产成人久久综合碰碰| 真人抽搐一进一出视频| 未满十八18禁止免费无码网站| 中文字幕乱码亚洲无线码三区| 亚洲va成无码人在线观看天堂| 国产精品白丝喷水在线观看| 亚洲国产精品久久久天堂麻豆宅男 | 337p日本欧洲亚洲大胆色噜噜| 人妻无码久久中文字幕专区| 一本一久本久a久久精品综合| 国产精品www夜色视频| 亚洲国产欧美国产综合久久| 久久精品超碰av无码| 抽插丰满内射高潮视频| 火箭视频在线观看精品| 在线亚洲专区高清中文字幕| 久久精品国产精品亚洲色婷婷 |