在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EPRS Antibody, FITC conjugated

EPRS Antibody, FITC conjugated

  • 中文名稱：
    EPRS兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA007747LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EPRS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EPRS
  • 別名：
    Bifunctional aminoacyl tRNA synthetase antibody; Bifunctional aminoacyl-tRNA synthetase antibody; Bifunctional glutamate/proline tRNA ligase antibody; Cell proliferation-inducing gene 32 protein antibody; DKFZp313B047 antibody; EARS antibody; Eprs antibody; GLNS antibody; Glu pro tRNA synthetase antibody; GLUPRORS antibody; GluRS antibody; Glutamate tRNA ligase antibody; Glutamatyl prolyl tRNA synthetase antibody; Glutaminyl tRNA synthetase antibody; Glutamyl prolyl tRNA synthetase antibody; Glutamyl tRNA synthetase antibody; Glutamyl-tRNA synthetase antibody; PARS antibody; PIG 32 antibody; PIG32 antibody; Proliferation inducing gene 32 protein antibody; Proliferation inducing protein 32 antibody; Proline tRNA ligase antibody; Proline--tRNA ligase antibody; Prolyl tRNA synthetase antibody; Prolyl-tRNA synthetase antibody; QARS antibody; QPRS antibody; SYEP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Bifunctional glutamate/proline--tRNA ligase protein (1207-1399AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition. Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan.
  • 基因功能參考文獻(xiàn)：
    1. five different EPRS mutations were identified. PMID: 29576217
    2. Data indicate the necessity of EPRS for proliferation of tamoxifen-resistant estrogen receptor (ER+) breast cancer, but not ER- breast cancer cells. PMID: 27612429
    3. analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3 PMID: 26472928
    4. Dynamic model simulations predicted an inhibitory GAIT-element-interacting factor to account for this relationship and led to the identification of a truncated form of EPRS, a GAIT constituent that mediates binding to target transcripts. PMID: 22386318
    5. Study reveals a unique role of Cdk5/p35 in activation of the major noncanonical function of EPRS, namely translational control of macrophage inflammatory gene expression. PMID: 21220307
    6. Results show that glutamyl-prolyl-tRNA synthetase has a regulated, noncanonical activity that blocks synthesis of a specific protein. PMID: 15479637
    7. Essentiality of this enzyme's domains in its noncanonical function of regulating inflammatory gene expression. PMID: 18374644
    8. EPRS phosphorylation events regulate GAIT-mediated gene silencing. PMID: 19647514

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family, Glutamate--tRNA ligase type 2 subfamily; Class-II aminoacyl-tRNA synthetase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3418

    OMIM: 138295

    KEGG: hsa:2058

    STRING: 9606.ENSP00000355890

    UniGene: Hs.497788



主站蜘蛛池模板： 亚洲色欲av无码成人专区| 日本丰满少妇高潮呻吟| 日日躁狠狠躁狠狠爱| 欧美日本日韩aⅴ在线视频| 131美女爱做视频免费| 亚洲欧美综合在线天堂| 久久久无码中文字幕久...| 精品国产杨幂在线观看| 三级无码在钱av无码在钱 | 成熟丰满熟妇av无码区| www国产精品内射老熟女| 亚洲欧洲国产码专区在线观看| 欧洲国产精品无码专区影院| 丰满人妻一区二区三区免费视频| 国产亚洲美女精品久久久| 国产精品久久久久久爽爽爽床戏| 少妇午夜av一区| 亚洲爆乳无码精品aaa片蜜桃| 羞羞色男人的天堂| 日韩av无码一区二区三区无码| 国产精品扒开腿做爽爽爽a片唱戏| 亚洲不卡中文字幕无码| 超清无码av最大网站| 中文字幕人妻被公上司喝醉506| 国产精品久久无码一区| 久99久无码精品视频免费播放| 久久久久 亚洲 无码 av 专区| 国产性生交xxxxx无码| 99精品国产在热久久婷婷| 色8激情欧美成人久久综合电影| 综合色一色综合久久网| 青青久在线视频免费观看| 男女野外做爰全过程69影院| 日本19禁啪啪吃奶大尺度| 男人用嘴添女人下身免费视频| 日韩中文字幕免费视频| 国产日韩另类综合11页| 欧洲美女黑人粗性暴交| 国产女爽爽精品视频天美传媒| 亚洲性人人天天夜夜摸| 亚洲 卡通 欧美 制服 中文 |