在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EPHB1 Antibody

EPHB1 Antibody

  • 中文名稱：
    EPHB1兔多克隆抗體
  • 貨號：
    CSB-PA008066
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COS-7 cells using EphB1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    EPHB1
  • 別名：
    Cek 6 antibody; EK6 antibody; ELK antibody; Elkh antibody; EPH receptor B1 antibody; Eph tyrosine kinase 2 antibody; EPH-like kinase 6 antibody; Ephb1 antibody; EPHB1_HUMAN antibody; Ephrin type B receptor 1 antibody; Ephrin type-B receptor 1 antibody; EPHT2 antibody; HEK 6 antibody; HEK6 antibody; NET antibody; Neuronally-expressed EPH-related tyrosine kinase antibody; soluble EPHB1 variant 1 antibody; Tyrosine protein kinase receptor EPH 2 antibody; Tyrosine-protein kinase receptor EPH-2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human EphB1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation.
  • 基因功能參考文獻：
    1. SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma tumorigenesis. PMID: 29550816
    2. investigate NET could modulate one's attention orientation to facial expressions, we categorized individuals according to the genotypes of the -182 T/C (rs2242446) polymorphism. Our results indicated that the -182 T/C polymorphism significantly modulated attention orientation to facial expressions, of which the CC genotype facilitated attention reorientation to the locations where cued faces were previously presented. PMID: 27541794
    3. some of the mutations found in EPHB1 may contribute to an increased invasive capacity of cancers. PMID: 28108514
    4. Association of EPHB1 rs11918092 with symptoms of schizophrenia in Chinese Zhuang and Han populations. PMID: 27028544
    5. The tumor-suppressor function of EphB1 is clinically relevant across many malignancies, suggesting that EphB1 is an important regulator of common cancer cell transforming pathways. PMID: 25944917
    6. In medulloblastoma cell lines, EphB1 downregulation or knockdown reduced cell growth, viability, cell-cycle regulator expression, and migration, but increased radiosensitivity and the percentage of cells in G1 phase of the cell cycle. PMID: 25879388
    7. Our results indicate that EphB1 may be involved in carcinogenesis of renal cell carcinoma PMID: 25120806
    8. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. PMID: 24716914
    9. The study presents the first structure of the EphB1 tyrosine kinase domain determined by X-ray crystallography to 2.5A. PMID: 24677421
    10. EphB1 and Ephrin-B could be regarded as independent good prognostic factors and important biological markers for Squamous cell/adenosquamous carcinoma and adenocarcinoma of gallbladder. PMID: 24606480
    11. Our data indicate that loss of EphB1 protein is associated with metastasis and poorer survival in patients with serous ovarian cancer PMID: 24427352
    12. Low EphB1 expression is associated with glioma. PMID: 24121831
    13. EphB1 stimulation triggered approximately 50% serine-threonine PTEN dephosphorylation and PTEN-Cbl complex disruption, a process requiring PTEN protein phosphatase activity. PMID: 23118026
    14. No association is found for EPH receptor B1 and susceptibility to schizophrenia. PMID: 21041834
    15. EPHB1 polymorphisms may be associated with susceptibility to hepatocellular carcinoma in the Korean population. PMID: 21763378
    16. Data show that EphB receptors interact with E-cadherin and with the metalloproteinase ADAM10 at sites of adhesion. PMID: 21804545
    17. analysis of EphB1, EphB2, and EphB4-binding peptides interaction with antagonists with ephrin-like affinity PMID: 15722342
    18. The ubiquitin ligase Cbl induces the ubiquitination and lysosomal degradation of activated EphB1, a process requiring EphB1 and Src kinase activity. PMID: 18034775
    19. Transgenic EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus. PMID: 18057206
    20. Loss of expression of EphB1 protein in gastric carcinoma is associated with invasion and metastasis PMID: 18424888
    21. EphB1 may have roles in the pathogenesis and development of colorectal cancer. PMID: 18931529

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性：
    Preferentially expressed in brain.
  • 數據庫鏈接：

    HGNC: 3392

    OMIM: 600600

    KEGG: hsa:2047

    STRING: 9606.ENSP00000381097

    UniGene: Hs.116092



主站蜘蛛池模板： 无码h黄肉动漫在线观看| 内射少妇一区27p| 日本乱偷人妻中文字幕在线| 窝窝午夜精品一区二区| 双腿张开被9个黑人调教影片| 久久久久久国产精品美女| 成人国产一区二区三区精品不卡| 最新精品国偷自产在线美女足| 性一交一乱一伦一色一情孩交| 亚洲综合av永久无码精品一区二区| 免费国产a国产片高清网站| 婷婷五月开心亚洲综合在线| 麻豆果冻传媒2021精品传媒一区下载 | 四房播色综合久久婷婷| 一个人看的视频www在线| 免费观看全黄做爰大片国产| 好吊视频一区二区三区| 精品国产三级a在线观看| 插插插精品亚洲一区| 大屁股熟女一区二区三区| 久久久久成人精品无码| 亚洲欧洲专线一区| 久久婷婷国产剧情内射白浆| 国产又色又刺激高潮视频| 久久久亚洲精品成人| 熟女精品视频一区二区三区| 日韩精品无码免费专区午夜不卡| 日本高清二区视频久二区| 色88久久久久高潮综合影院| 国产超碰人人爽人人做| 国产精品色无码av在线观看| 无码一区二区三区av免费蜜桃| 最新欧美精品一区二区三区| 99久久国产露脸国语对白| 国产毛片精品av一区二区| 人妻无码手机在线中文| 婷婷综合久久中文字幕| 国产精品美女久久久久久2018| 人与人性恔配视频免费| 日韩 高清 无码 人妻| 精品久久人妻av中文字幕|