在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EPHA5 Antibody

  • 中文名稱:
    EPHA5兔多克隆抗體
  • 貨號:
    CSB-PA002363
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of A549 cells using EphA5 Polyclonal Antibody
    • Western Blot analysis of PC12 HELA cells using EphA5 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Brain-specific kinase antibody; bsk antibody; CEK 7 antibody; Eck like sequence 1 antibody; EHK 1 antibody; EHK-1 antibody; EK7 antibody; Els 1 antibody; EPH homology kinase 1 antibody; EPH-like kinase 7 antibody; EPHA5 antibody; EPHA5_HUMAN antibody; Ephrin type A receptor 5 antibody; Ephrin type-A receptor 5 antibody; HEK 7 antibody; hEK7 antibody; Receptor protein tyrosine kinase HEK 7 antibody; Rek 7 antibody; TYRO 4 antibody; Tyrosine protein kinase receptor EHK 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human EphA5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
  • 基因功能參考文獻:
    1. Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy PMID: 27582484
    2. Our data indicate that EphA5 receptor may be a tumor suppressor in colorectal carcinoma and it may be a new therapeutic target for colorectal carcinoma. PMID: 27651378
    3. EphA5 protein was negatively (0) or weakly (1+) expressed in 48 of 78 (61.5%), moderately (2+) expressed in 15 of 78 (19.2%) and strongly (3+) expressed in 15 of 78 (19.2%) tumour samples of clear cell renal cell carcinoma (ccRCC). Decreased expression of EphA5 was detected more often in females than in males PMID: 28421649
    4. the interactions of EphA5/ephrinA5 and/or EphA7/ephrinA5 between HSPCs and BMSCs, independently and cooperatively, play a role in HSPC colony formation through the upregulation of GM-CSFR. Furthermore, the adhesion/migration of HSPCs appears to be mediated in part through the activation of Rac1. PMID: 27988259
    5. Our results show that EphA5 may be a potential biomarker for distinguishing high-and low-grade ovarian serous carcinoma and a potential prognostic marker. PMID: 27887627
    6. Our study provides evidence that EphA5 is a potential target for epigenetic silencing in primary prostate cancer and is a potentially valuable prognosis predictor and thereapeutic marker for prostate cancer. PMID: 25609195
    7. demonstrate that a new monoclonal antibody against human EphA5 sensitized lung cancer cells and human lung cancer xenografts to radiotherapy and significantly prolonged survival, thus suggesting the likelihood of translational applications PMID: 25623065
    8. unbound EphA5 LBD appears to comprise an ensemble of open conformations that have only small variations over the loops and appear ready to bind ephrin-A ligands PMID: 24086308
    9. These results indicate that EphA5 may be a negative regulator of bone formation. PMID: 24029132
    10. Insertional translocation leading to a 4q13 duplication including the EPHA5 gene is associated with attention-deficit. hyperactivity disorder PMID: 23824631
    11. these data suggest that miR-34a is a negative modulator of chondrogenesis, particularly in migration of chondroblasts, by targeting EphA5 and resulting inhibition of cellular condensation during chondrogenesis of chick limb mesenchymal cells. PMID: 22079638
    12. Eph-A5 and Eph-A7 staining intensity was identified as independent prognostic factors for pancreatic ductal adenocarcinoma PMID: 19949912
    13. EphA5 might be a potential target for epigenetic silencing in primary breast cancer and a valuable molecular marker for breast cancer carcinogenesis and progression. PMID: 19733895

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性:
    Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
  • 數據庫鏈接:

    HGNC: 3389

    OMIM: 600004

    KEGG: hsa:2044

    STRING: 9606.ENSP00000273854

    UniGene: Hs.654492



主站蜘蛛池模板: 亚洲成h人av无码动漫无遮挡| 国产线观看免费观看| 婷婷网亚洲色偷偷男人的天堂| 成年女人午夜性视频| 久久一日本综合色鬼综合色| 人妻精品人妻无码一区二区三区 | 国产精品99久久久久久宅男| 久久国产欧美日韩精品| 久久综合狠狠色综合伊人| 精品无码综合一区二区三区| 亚洲高潮喷水无码av电影| 国产午夜无码福利在线看网站| 日本在线视频www鲁啊鲁| 国产成人精品无码专区| 久久亚洲美女精品国产精品| 蜜臀av在线无码国产| 亚洲一区二区三区在线网址| 真人抽搐一进一出视频| 久久久无码精品亚洲日韩蜜桃| 国产mv在线天堂mv免费观看| 人人婷婷人人澡人人爽| 日本又黄又爽gif动态图| 久久久久久亚洲精品| 无码人妻一区二区三区免费n鬼沢| 国产精品久久久久秋霞鲁丝| 日韩免费人妻av无码专区蜜桃| 国产欧美亚洲日韩图片| 97久久超碰国产精品2021| 狠狠色丁香婷婷久久综合| 久久综合精品国产一区二区三区无码| 真人啪啪高潮喷水呻吟无遮挡| 人妻中出受孕 中文字幕在线| 欧美国产国产综合视频| 亚洲妇女行蜜桃av网网站| 国产av偷闻女邻居内裤被发现| 欧美放荡的少妇| 日日噜噜噜夜夜爽爽狠狠| 高清情侣国语自产拍| 久久久一本精品久久精品六六 | 成 人片 黄 色 大 片| 日本成熟老妇乱|