在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EPHA5 Antibody

  • 中文名稱:
    EPHA5兔多克隆抗體
  • 貨號:
    CSB-PA002363
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of A549 cells using EphA5 Polyclonal Antibody
    • Western Blot analysis of PC12 HELA cells using EphA5 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Brain-specific kinase antibody; bsk antibody; CEK 7 antibody; Eck like sequence 1 antibody; EHK 1 antibody; EHK-1 antibody; EK7 antibody; Els 1 antibody; EPH homology kinase 1 antibody; EPH-like kinase 7 antibody; EPHA5 antibody; EPHA5_HUMAN antibody; Ephrin type A receptor 5 antibody; Ephrin type-A receptor 5 antibody; HEK 7 antibody; hEK7 antibody; Receptor protein tyrosine kinase HEK 7 antibody; Rek 7 antibody; TYRO 4 antibody; Tyrosine protein kinase receptor EHK 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human EphA5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
  • 基因功能參考文獻:
    1. Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy PMID: 27582484
    2. Our data indicate that EphA5 receptor may be a tumor suppressor in colorectal carcinoma and it may be a new therapeutic target for colorectal carcinoma. PMID: 27651378
    3. EphA5 protein was negatively (0) or weakly (1+) expressed in 48 of 78 (61.5%), moderately (2+) expressed in 15 of 78 (19.2%) and strongly (3+) expressed in 15 of 78 (19.2%) tumour samples of clear cell renal cell carcinoma (ccRCC). Decreased expression of EphA5 was detected more often in females than in males PMID: 28421649
    4. the interactions of EphA5/ephrinA5 and/or EphA7/ephrinA5 between HSPCs and BMSCs, independently and cooperatively, play a role in HSPC colony formation through the upregulation of GM-CSFR. Furthermore, the adhesion/migration of HSPCs appears to be mediated in part through the activation of Rac1. PMID: 27988259
    5. Our results show that EphA5 may be a potential biomarker for distinguishing high-and low-grade ovarian serous carcinoma and a potential prognostic marker. PMID: 27887627
    6. Our study provides evidence that EphA5 is a potential target for epigenetic silencing in primary prostate cancer and is a potentially valuable prognosis predictor and thereapeutic marker for prostate cancer. PMID: 25609195
    7. demonstrate that a new monoclonal antibody against human EphA5 sensitized lung cancer cells and human lung cancer xenografts to radiotherapy and significantly prolonged survival, thus suggesting the likelihood of translational applications PMID: 25623065
    8. unbound EphA5 LBD appears to comprise an ensemble of open conformations that have only small variations over the loops and appear ready to bind ephrin-A ligands PMID: 24086308
    9. These results indicate that EphA5 may be a negative regulator of bone formation. PMID: 24029132
    10. Insertional translocation leading to a 4q13 duplication including the EPHA5 gene is associated with attention-deficit. hyperactivity disorder PMID: 23824631
    11. these data suggest that miR-34a is a negative modulator of chondrogenesis, particularly in migration of chondroblasts, by targeting EphA5 and resulting inhibition of cellular condensation during chondrogenesis of chick limb mesenchymal cells. PMID: 22079638
    12. Eph-A5 and Eph-A7 staining intensity was identified as independent prognostic factors for pancreatic ductal adenocarcinoma PMID: 19949912
    13. EphA5 might be a potential target for epigenetic silencing in primary breast cancer and a valuable molecular marker for breast cancer carcinogenesis and progression. PMID: 19733895

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性:
    Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
  • 數據庫鏈接:

    HGNC: 3389

    OMIM: 600004

    KEGG: hsa:2044

    STRING: 9606.ENSP00000273854

    UniGene: Hs.654492



主站蜘蛛池模板: 国产亚洲精品自在久久| 亚洲精品成人网站在线| 成人丝袜激情一区二区| 一 级做人爱全视频在线看| 超碰97人人做人人爱亚洲| 精品一卡2卡三卡4卡乱码精品视频 | 成人免费直播| 色偷偷噜噜噜亚洲男人| 新版天堂资源中文www连接| 丰满少妇被猛烈进入av久久| 亚洲大尺度无码专区尤物| 国产思思99re99在线观看| 国产成人亚洲综合无码18禁h| 日韩高清在线观看永久| 夜夜爽日日澡人人添| 精品人妻无码一区二区三区换脸| 亚洲成色综合网站在线| 西西人体午夜大胆无码视频| 亚洲中文字幕无码爆乳av| 99精品国产一区二区| 日韩国产精品无码一区二区三区| 无码av无码天堂资源网影音先锋 | 国产亚洲日本精品成人专区| 欧美日本日韩aⅴ在线视频| 激情影院内射美女| 大香伊蕉在人线国产免费| 国产卡二卡三卡四卡免费网址| 影视先锋男人无码在线| 国模小黎自慰gogo人体| 在线观看黄a∨免费无毒网站 | 欧美日韩无线码在线观看| 51久久国产露脸精品国产| 精品国产乱码久久久久软件| 蜜臀av国产精品久久久久| 华人少妇被黑人粗大的猛烈进| 2018av天堂在线视频精品观看| 一本av高清一区二区三区| 日本二区三区欧美亚洲国| 好湿好紧太硬了我太爽了视频| 亚洲另类欧美综合在线| 四库影院永久四虎精品国产|