在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EPHA1 Antibody

EPHA1 Antibody

  • 中文名稱：
    EPHA1兔多克隆抗體
  • 貨號：
    CSB-PA007720LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: EPHA1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 109, 53, 52 kDa
      Observed band size: 109, 30 kDa
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA007720LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA007720LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA007720LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EPHA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EPHA1
  • 別名：
    EPH antibody; EPH receptor A1 antibody; EPH tyrosine kinase 1 antibody; EPH tyrosine kinase antibody; Epha1 antibody; EPHA1_HUMAN antibody; Ephrin receptor Eph A1 antibody; Ephrin type A receptor 1 antibody; Ephrin type-A receptor 1 antibody; EPHT 1 antibody; EPHT antibody; EPHT1 antibody; Erythropoietin producing hepatoma amplified sequence antibody; Erythropoietin-producing hepatoma receptor antibody; Esk antibody; hEpha1 antibody; MGC163163 antibody; Oncogene EPH antibody; Soluble EPHA1 variant 1 antibody; Soluble EPHA1 variant 2 antibody; Tyrosine protein kinase receptor EPH antibody; Tyrosine-protein kinase receptor EPH antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Ephrin type-A receptor 1 protein (296-414AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，EPHA1 Antibody (CSB-PA007720LA01HU)，的標記方式是Non-conjugated。對于EPHA1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA007720LB01HU EPHA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA007720LC01HU EPHA1 Antibody, FITC conjugated
    Biotin CSB-PA007720LD01HU EPHA1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 基因功能參考文獻：
    1. EphA1 expression is decreased in ovarian serous carcinoma compared with normal fallopian tube and benign ovarian serous cystadenoma. Decreased EphA1 expression was more often detected in high-grade tumors. PMID: 29393455
    2. Results show that EPHA1 expression is up-regulated in ovarian cancer (OC) cells and provide evidence that it may promote the aggression of some OC cells. PMID: 28739735
    3. EPHA1 suppresses spreading and adhesion of HRT18 colorectal cancer cells through deactivation of ERK and JNK signaling pathways. PMID: 26977017
    4. Data indicate that EphA1 protein may be a new marker for the prognosis of clear cell renal cell carcinoma. PMID: 26261568
    5. High expression of EphA1 was associated with metastasis and recurrence in Gastric Cancer. PMID: 25391265
    6. This study suggests EPHA1 (rs11771145) interferes with the pathological alteration of the hippocampus and the lateral occipitotemporal and inferior temporal gyri throughout the Alzheimer's disease process, leading to a lower risk of Alzheimer's disease. PMID: 25182741
    7. EphrinA1 plays an important role in the TNF-alpha-mediated adhesion of monocytes to endothelial cells. PMID: 25451169
    8. Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma. PMID: 25025847
    9. two states of the EphA1 transmembrane helix dimer PMID: 25286141
    10. Suggest EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer. PMID: 24040450
    11. High Eph A1 expression is associated with choriocarcinoma invasion. PMID: 23429488
    12. Results show that EphA1 appears to be a differentiation marker for esophageal squamous cells, and its increased expression is positively associated with lymph node metastasis and advanced disease stage. PMID: 23030051
    13. EphrinA1 is released in three forms from cancer cells by matrix metalloproteases PMID: 22688511
    14. The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer. PMID: 21503576
    15. found independent evidence for association for Alzheimer's disease susceptibility loci at EPHA1, CD33 and CD2AP PMID: 21460840
    16. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. PMID: 21460841
    17. The EphA1 expression level is a potential prognostic marker in gastric carcinoma, and may provide a novel target of therapy for gastric carcinoma. PMID: 21042754
    18. Eph-A1 staining intensity was significantly associated with tumor size and tumor histopathological stage in pancreatic ductal adenocarcinoma PMID: 19949912
    19. Suppression of EphA1 expression in Huh-7 cells reduced their outgrowth when inoculated in the subcutaneous space in the flank of nude mice, presumably through angiogenesis inhibition since microvessel density was found to be inhibited. PMID: 20043122
    20. EphA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. PMID: 16862074
    21. I 12 acquired a higher affinity toward EphA2 with K(d) 18 nm and inhibited vascular endothelial growth factor-dependent angiogenic invasion in a Matrigel plug assay PMID: 18308734
    22. Results suggest that EphA1-receptor transmembrane domains contribute to the dimerization-mediated receptor activation. PMID: 18590698
    23. analysis of the spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 PMID: 18728013
    24. In EphA1 null transgenic mice a possible role for EphA1 in tissue patterning and hormone-induced apoptotic processes is indicated. PMID: 18802966
    25. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. PMID: 18990944
    26. EphA1 may play different roles during the different stages of colorectal carcinoma progression. PMID: 19011600
    27. EphA1 regulates cell morphology and motility through the ILK-RhoA-ROCK pathway. PMID: 19118217
    28. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. PMID: 19277044

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性：
    Overexpressed in several carcinomas.
  • 數據庫鏈接：

    HGNC: 3385

    OMIM: 179610

    KEGG: hsa:2041

    STRING: 9606.ENSP00000275815

    UniGene: Hs.89839



主站蜘蛛池模板： 制服视频在线一区二区| 亚洲人成色77777在线观看| 免费三级网站| 99精品国产在热久久| 亚洲狠狠色丁香婷婷综合| 97se亚洲国产综合自在线| 亚洲欧洲中文日韩乱码av| 免费做a爰片久久毛片a片| 国产精品成人免费一区久久羞羞| 国产精品国语对白露脸在线播放| 亚洲精品国产成人精品软件| 欧美多毛肥胖老妇做爰| 尤物视频在线观看| 欧美xxxx做受欧美1314| 另类亚洲综合区图片小说区| 国产产在线精品亚洲aavv| 小宝极品内射国产在线| 女人被男人爽到呻吟的视频| 成人麻豆日韩在无码视频| 精品无人区码一码二码三码区别| 国产精品无码久久四虎| 水蜜桃色314在线观看| 午夜寂寞少妇aaa片毛片| 日本护士毛茸茸xx| 国产精品日本亚洲欧美| 免费中文熟妇在线影片| 中国熟妇牲交视频| 麻豆日产精品卡2卡3卡4卡5卡| 在线观看国产精品普通话对白精品 | 少妇仑乱a毛片| 无码专区男人本色| 国产成人av免费网址| 国产98在线 | 免费| 亚洲精品一区二区三区四区乱码 | 亚洲区小说区图片区qvod | 丰满多毛的大隂户毛茸茸| 婷婷色香五月综合缴缴情| 日本高清成本人视频一区| 成人欧美一区二区三区1314| 欧美成人a天堂片在线观看| 欧美激欧美啪啪片|