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  4. ENY2 Antibody, Biotin conjugated

ENY2 Antibody, Biotin conjugated

  • 中文名稱：
    ENY2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA889067LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ENY2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ENY2
  • 別名：
    1810057B09Rik antibody; 6720481I12 antibody; DC6 antibody; e(y)2 antibody; Enhancer of yellow 2 transcription factor homolog antibody; eny2 antibody; ENY2_HUMAN antibody; Ey2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription and mRNA export factor ENY2 protein (1-101AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.
  • 基因功能參考文獻：
    1. ATXN7L3 and ENY2 orchestrate activities of multiple deubiquitinating enzymes, including USP27x and USP51, and that imbalances in these activities likely potentiate human diseases including cancer. PMID: 27132940
    2. ATXN7L3, USP22, & ENY2 are required cofactors for full transcriptional activity by nuclear receptors. The deubiquitinase activity of TFTC/STAGA HAT counteracts heterochromatin silencing & is a positive cofactor for in vivo nuclear receptor activation. PMID: 18206972
  • 亞細胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    ENY2 family
  • 數據庫鏈接：

    HGNC: 24449

    KEGG: hsa:56943

    STRING: 9606.ENSP00000429986

    UniGene: Hs.492555



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