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  4. EMG1 Antibody

EMG1 Antibody

  • 中文名稱：
    EMG1兔多克隆抗體
  • 貨號：
    CSB-PA007636GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    EMG1
  • 別名：
    18S rRNA (pseudouridine(1248)-N1)-methyltransferase antibody; 18S rRNA Psi1248 methyltransferase antibody; C2F antibody; C2f protein antibody; EMG 1 antibody; EMG1 antibody; EMG1 N1 specific pseudouridine methyltransferase antibody; EMG1 nucleolar protein homolog (S cerevisiae) antibody; EMG1 nucleolar protein homolog antibody; essential for mitotic growth 1 antibody; FLJ60792 antibody; Grcc2f antibody; NEP1 antibody; NEP1_HUMAN antibody; Nucleolar protein EMG1 homolog antibody; Protein C2f antibody; Ribosomal RNA small subunit methyltransferase Nep1 antibody; Ribosome biogenesis protein NEP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human EMG1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
  • 基因功能參考文獻：
    1. Our findings further indicate that in Bowen-Conradi syndrome, nuclear disassembly of the import complex and release of EMG1D86G lead to its nuclear aggregation and degradation, resulting in the reduced nucleolar recruitment of the RNA methyltransferase and defects in the biogenesis of the small ribosomal subunit. PMID: 27798105
    2. Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. PMID: 19463982
  • 相關疾病：
    Bowen-Conradi syndrome (BWCNS)
  • 亞細胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase NEP1 family
  • 數據庫鏈接：

    HGNC: 16912

    OMIM: 211180

    KEGG: hsa:10436

    UniGene: Hs.558447



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