在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ELP1 Antibody, FITC conjugated

  • 中文名稱:
    ELP1兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA011571LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ELP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ELP1
  • 別名:
    DKFZp781H1425 antibody; DYS antibody; Dysautonomia (Riley Day syndrome hereditary sensory autonomic neuropathy type III) antibody; Elongator complex protein 1 antibody; ELP 1 antibody; ELP1 antibody; ELP1_HUMAN antibody; FD antibody; FLJ12497 antibody; IKAP antibody; IkappaB kinase complex associated protein antibody; IkappaB kinase complex-associated protein antibody; ikbkap antibody; IKI 3 antibody; IKI3 antibody; IKK complex associated protein antibody; IKK complex-associated protein antibody; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein antibody; OTTHUMP00000063889 antibody; p150 antibody; TOT 1 antibody; TOT1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Elongator complex protein 1 protein (1107-1258AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).
  • 基因功能參考文獻:
    1. overexpression of miR-203a-3p leads to a decrease of NOVA1, counter-balanced by an increase of IKAP, supporting a potential interaction between NOVA1 and IKAP. PMID: 27483351
    2. IKAP might be a vesicular like protein that might be involved in neuronal transport in hESC derived PNS neurons PMID: 26437462
    3. The formation of the Elp1 dimer contributes to its stability in vitro and in vivo and is required for the assembly of human Elongator complexes. PMID: 26261306
    4. IKBKAP mRNA levels decreased during a familial dysautonomia crisis and returned to baseline after recovery. The cause-and-effect relationship is unclear. PMID: 24268683
    5. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia. PMID: 23515154
    6. Digoxin-mediated repression of SRSF3 expression plays a role in the digoxin-mediated inclusion of exon 20 in the IKBKAP transcript generated from the familial dysautonomia mutant allele. PMID: 23711097
    7. Combined treatment with epigallocatechin gallate and genistein synergistically upregulates wild-type IKBKAP-encoded RNA and protein levels in familial dysautonomia-derived cells. PMID: 22495984
    8. IKAP plays pleiotropic roles in both the peripheral and central nervous systems PMID: 22384137
    9. IKAP/hELP1 deficiency has an effect on gene expression in differentiating neuroblastoma cells, and possibly on familial dysautonomia PMID: 21559466
    10. IKK complex-associated protein deficiency upregulates the microtubule destabilizing protein SCG10 and, in parallel, disorganizes the cytoskeleton PMID: 21273291
    11. Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells PMID: 21209961
    12. IKAP regulates contactin levels for appropriate cell-cell adhesion that could modulate neuronal growth of neurons during development PMID: 20671422
    13. IKAP is critical for the development of afferent baroreflex pathways and has therapeutic implications in the management of these patients. PMID: 21098405
    14. IKBKAP is a candidate gene for Hirschsprung's disease and was mapped to chromosome 9q31 locus. PMID: 20361209
    15. novel role for the I kappa B kinase complex-associated protein (IKAP) in the regulation of activation of the mammalian stress response via the c-Jun N-terminal kinase (JNK)-signaling pathway PMID: 12058026
    16. Genetics of familial dysautonomia; tissue-specific expression of a splicing mutation (REVIEW) PMID: 12102458
    17. Tissue-specific reduction in splicing efficiency of this protein is due to the major mutation associated with familial dysautonomia. PMID: 12577200
    18. The study results suggest that the polymorphisms in the coding region of the IKAP gene are unlikely to contribute to atopic disease risk in the Czech population. PMID: 12774215
    19. whereas IKBKAP (Elongator) is recruited to both target and nontarget genes, only target genes display histone H3 hypoacetylation and progressively lower RNAPII density through the coding region in familial dysautonomia cells PMID: 16713582
    20. Neurodevelopmental disease familial dysautonomia (FD)caused by a single-base change in the 5' splice site (5'ss) of intron 20 in the IKBKAP gene (c.2204+6T>C). PMID: 16964593
    21. investigated the nature of the FD splicing defect and the mechanism by which kinetin improves exon inclusion PMID: 17206408
    22. IKAP/hELP1 may play a role in oligodendrocyte differentiation and/or myelin formation. PMID: 17591626
    23. description of a humanized IKBKAP transgenic mouse that models a tissue-specific human splicing defect PMID: 17644305
    24. IKBKAP may have a role in familial dysautonomia PMID: 18091349
    25. Evidence for the role of the cytosolic interactions of IKAP in cell adhesion and migration, and support the notion that cell-motility deficiencies could contribute to familial dysautonomia. PMID: 18303054
    26. IKAP is crucial for both vascular and neural development during embryogenesis and that protein function is conserved between mouse and human. PMID: 19015235

    顯示更多

    收起更多

  • 相關疾病:
    Neuropathy, hereditary sensory and autonomic, 3 (HSAN3)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    ELP1/IKA1 family
  • 數據庫鏈接:

    HGNC: 5959

    OMIM: 223900

    KEGG: hsa:8518

    STRING: 9606.ENSP00000363779

    UniGene: Hs.494738



主站蜘蛛池模板: 色偷偷亚洲第一成人综合网址| 亚洲成a∨人片在无码2023| 午夜福利国产成人a∨在线观看| 国产尤物在线视精品在亚洲| 国产婷婷色一区二区三区| 久久久久久国产精品无码超碰| 国产午夜精品一区二区三区老 | 久久久久久亚洲综合影院| 国产精品无码一区二区三区免费| 男人扒女人添高潮视频| 国产真实野战在线视频| 97精品久久天干天天| 免费人成再在线观看视频| 日韩av无码精品一二三区| 国产男女爽爽爽免费视频| 狠狠色噜噜狠狠狠狠888奇禾| 国产做爰xxxⅹ久久久小说| 把腿张开老子臊烂你多p视频 | 国产伦理一区二区| 寂寞骚妇被后入式爆草抓爆| 岛国4k人妻一区二区三区| 99久久国产露脸精品竹菊传媒| 国产人妖视频一区二区| 99蜜桃在线观看免费视频网站| 日韩人妻无码精品系列| 久久国内精品自在自线400部| 免费人妻av无码专区| 国产爆乳无码视频在线观看| 国产偷国产偷亚洲清高网站| 国产精品av在线| 色综合色狠狠天天综合色 | 正在播放熟妇群老熟妇456| 日本特黄特色aaa大片免费| 久热这里只有精品视频6| 成人无码av一区二区三区| 亚洲乱码一区av春药高潮| 免费纯肉3d动漫无码网站| 自拍校园亚洲欧美另类| 亚洲精品中文字幕一区二区三区| 免费又黄又硬又爽大片| 色婷婷久久久swag精品|