在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ELL2 Antibody

ELL2 Antibody

  • 中文名稱：
    ELL2兔多克隆抗體
  • 貨號：
    CSB-PA008287
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ELL2
  • 別名：
    ELL related RNA polymerase II elongation factor antibody; Ell2 antibody; ELL2_HUMAN antibody; Elongation factor for RNA polymerase II 2 antibody; Elongation factor RNA for polymerase II 2 antibody; Elongation factor RNA polymerase II 2 antibody; RNA polymerase II elongation factor ELL2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ELL2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
  • 基因功能參考文獻：
    1. Study in CD138+ plasma cells from 1630 multiple myeloma (MM) patients show that the MM risk allele at 5q15 lowers ELL2 expression in these cells, but not in peripheral blood or other tissues. PMID: 29695719
    2. Study reports the 2.0-A resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding site on AFF4, the ELLBow. The ELLBow consists of an N-terminal helix followed by an extended hairpin and occupies most of the concave surface of ELL2. This surface is important for the ability of ELL2 to promote HIV-1 Tat-mediated proviral transcription. PMID: 28134250
    3. Knockdown of RNA polymerase II elongation factor ELL2 (ELL2) sensitized prostate cancer cells to DNA damage and overexpression of ELL2 protected prostate cancer cells from DNA damage. PMID: 29179998
    4. expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating multiple myeloma clonal expansion. PMID: 28903037
    5. Results provide the first evidence that ELL2 is a direct target of miR-299 and increased ELL2 expression and down-regulation of miR-299 are associated with GBM progression and poor prognosis in patients. PMID: 28531325
    6. Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival PMID: 28858629
    7. These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer. PMID: 28870994
    8. multiple myeloma risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation PMID: 26007630
    9. Tax transactivates the ELL2 promoter in HTLV-1-infected T-cells. PMID: 25058508
    10. Loss of ELL2 in B cells results in decreased Igh secretory mRNA and decreased expression of Ig light chain plus genes involved in the unfolded protein response like XBP1, ATF6, BiP, cyclin B2, OcaB (BOB1, Pou2af1). PMID: 25238757
    11. Prostratin and HMBA, two well-studied activators of HIV transcription and latency, enhance ELL2 accumulation and SECs formation largely through decreasing Siah1 expression and ELL2 polyubiquitination. PMID: 22483617
    12. ELL2 addition regulates mRNA processing by enhancing poly(A) site choice and exon splice-site skipping PMID: 19749764

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    ELL/occludin family
  • 數據庫鏈接：

    HGNC: 17064

    OMIM: 601874

    KEGG: hsa:22936

    STRING: 9606.ENSP00000237853

    UniGene: Hs.192221



主站蜘蛛池模板： 免费乱理伦片在线观看八戒| 亚洲欧洲无码av一区二区三区| 久久久久久久久无码精品亚洲日韩 | 精品亚洲一区二区三区在线观看| 热re99久久精品国产99热| 国产白浆喷水在线视频| 人人爽人人片人人片av| 午夜无码性爽快影院6080| 国产欧美日韩精品a在线观看| 在线天堂中文官网| 人人做人人爽国产视 | 97婷婷狠狠成为人免费视频 | 精品国产乱码久久久久久下载| 337人体做爰大胆视频| 艳妇荡女欲乱双飞两中年熟妇| 鲁一鲁av2019在线| 9九色桋品熟女内射| 精品乱码一区二区三区四区| 色久悠悠婷婷综合在线亚洲 | 久久大香香蕉国产| 国产三级做爰在线播放| 无码人妻一区二区三区四区av| 在线 偷窥 制服 另类 | 女人扒开屁股桶爽30分钟| 又爽又黄又无遮挡的激情视频| 成视频年人黄网站视频福利| 久久久性色精品国产免费观看| 国产av无码专区亚洲版综合| 国内精品自线一区二区三区2021| 久久久www成人免费看片| 亚洲欧洲日产国码在线| 亚洲欧美日韩在线不卡| 国语自产精品视频在线第100页| 国偷自产一区二区三区在线视频| 中文乱码人妻系列一区二区| 人妻 色综合网站| 久久久久蜜桃精品成人片公司| 成人免费网站视频www| 野花在线无码视频在线播放| 天天躁夜夜踩很很踩2022| 无码人妻精品一区二区三区66|