在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ELF4 Antibody

ELF4 Antibody

  • 中文名稱：
    ELF4兔多克隆抗體
  • 貨號：
    CSB-PA857453ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA857453ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA857453ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA857453ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ELF4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ELF4
  • 別名：
    E74-like factor 4 antibody; ELF4 antibody; ELF4_HUMAN antibody; ELFR antibody; ETS-related transcription factor Elf-4 antibody; ETS-related transcription factor Elf4 antibody; MEF antibody; Myeloid Elf-1-like factor antibody; Myeloid Elf1-like factor antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ETS-related transcription factor Elf-4 protein (1-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
  • 基因功能參考文獻：
    1. Overall, these data indicate that hypoxia or HIF-1alpha positively regulates MEF expression and function. PMID: 27040637
    2. The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells PMID: 25482012
    3. The p53-MDM2-MEF axis is a feedback mechanism that exquisitely controls the balance of these transcriptional regulators. PMID: 25081543
    4. These studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation. PMID: 23217424
    5. enhanced HDM2 expression induced by mutant NPM1 may have a role in MEF/ELF4-dependent leukemogenesis PMID: 23393136
    6. MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression. PMID: 21465527
    7. Loss of ELF4 leads to increased quiescence in bone marrow endothelial cells by the deregulation of cyclin-dependent kinase-4 expression and to enhanced regeneration of sinusoidal blood vessels. PMID: 21350194
    8. Functional dissection of the transactivation mechanisms of the ETS transcription factor MEF PMID: 12151102
    9. MEF is an important regulator of IL-8 expression PMID: 14625302
    10. promyelocytic leukemia protein, but not Sp100, induced the accumulation of MEF in PML nuclear bodies and MEF and PML physically interacted, stimulating MEF transcriptional activity, resulting in the up-regulation of endogenous lysozyme expression. PMID: 14976184
    11. regulation in epithelial cells by Sp1 PMID: 15907486
    12. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. PMID: 16303180

    顯示更多

    收起更多

  • 相關疾?。?/div>
    A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.
  • 亞細胞定位：
    Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML.
  • 蛋白家族：
    ETS family
  • 組織特異性：
    Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cel
  • 數據庫鏈接：

    HGNC: 3319

    OMIM: 300775

    KEGG: hsa:2000

    STRING: 9606.ENSP00000311280

    UniGene: Hs.271940



主站蜘蛛池模板： 国产男女性潮高清免费网站| 国产成人无码午夜视频在线播放 | 国产v亚洲v天堂无码久久久| 色综合天天无码网站| 爆乳高潮喷水无码正在播放| 欧美xxxx做受欧美88| 青青草国产成人99久久| 在线欧美日韩制服国产| 被窝影院午夜无码国产| 欧美精品一区二区三区在线| 亚洲第一女人av| 精品国产无套在线观看| 精品日韩亚洲欧美高清a| 一边吃奶一边做动态图| 亚洲熟熟妇xxxx| 亚洲aⅴ永久无码一区二区三区| 国产亚洲日韩一区二区三区 | 无码人妻久久一区二区三区app| 亚洲人成网站色www| 欧美人与禽zoz0性伦交| 久久婷婷国产剧情内射白浆| 国产无套粉嫩白浆在线观看| 欧美变态另类刺激| 野花社区在线www日本| 日韩欧美亚洲中文乱码| 国产在线视频www色| 欧美疯狂性受xxxxx喷水| 曰本大码熟中文字幕| 亚洲图片综合图区20p| 国产麻豆天美果冻无码视频| 久久久精品2020免费观看| 狂野欧美激情性xxxx在线观看| 国产偷国产偷亚洲高清app| 日韩精品区一区二区三vr| 18禁亚洲深夜福利入口| 午夜一区二区亚洲福利| 业余 自由 性别 成熟偷窥| 无码国产偷倩在线播放| 无码熟妇人妻av在线网站| 国产午夜成人久久无码一区二区| 日韩精品乱码av一区二区|