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  4. ELF2 Antibody, Biotin conjugated

ELF2 Antibody, Biotin conjugated

  • 中文名稱：
    ELF2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA618015LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ELF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ELF2
  • 別名：
    ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor), ELF2, NERF
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ETS-related transcription factor Elf-2 protein (1-353aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; Isoform 2 may function in repression of RUNX1-mediated transactivation.
  • 基因功能參考文獻(xiàn)：
    1. Mutations in eIF2B genes cause vanishing white matter disease due to translation defects. PMID: 29632131
    2. Our findings collectively support a potential role of triiodothyronine and its receptor in tumor growth inhibition through regulation of ELF2 PMID: 26968954
    3. PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway. PMID: 28728844
    4. angiopoietin-1 regulates expression of NERF2 and its own receptor in hypoxic cells. PMID: 11967990
    5. NERF/ELF-2 physically interacts with AML1 and mediates opposing effects on AML1-mediated transcription of the B cell-specific blk gene PMID: 14970218
    6. These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress. PMID: 17368566
    7. ELF2 transactivates VCP promoter through binding to two motifs, with a predominant contribution of the upstream one. PMID: 18544453
    8. Affinity of the CAL PDZ domain for the cystic fibrosis transmembrane conductance regulator (CFTR) C-terminus is much weaker than that of the NHERF1/NHERF2 domains, enabling wild-type CFTR to avoid premature entrapment in the lysosomal pathway. PMID: 18754678

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 組織特異性：
    Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung,
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3317

    KEGG: hsa:1998

    STRING: 9606.ENSP00000265495

    UniGene: Hs.634040



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