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EIF4ENIF1 Antibody, FITC conjugated

  • 中文名稱:
    EIF4ENIF1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA873633LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EIF4ENIF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EIF4ENIF1
  • 別名:
    2610509L04Rik antibody; 4E T antibody; 4E-T antibody; 4ET antibody; 4ET_HUMAN antibody; A930019J01Rik antibody; AA410001 antibody; AU021239 antibody; Clast 4 antibody; Clast4 antibody; D11Ertd166e antibody; eIF4E transporter antibody; Eif4enif1 antibody; Eukaryotic translation initiation factor 4E nuclear import factor 1 antibody; Eukaryotic translation initiation factor 4E transporter antibody; FLJ21601 antibody; FLJ26551 antibody; OTTMUSP00000000698 antibody; OTTMUSP00000005193 antibody; OTTMUSP00000005194 antibody; OTTMUSP00000036075 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Eukaryotic translation initiation factor 4E transporter protein (340-630AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism.
  • 基因功能參考文獻:
    1. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
    2. our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap PMID: 26027925
    3. neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. PMID: 25456498
    4. that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions PMID: 23991149
    5. This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. PMID: 24335285
    6. Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency. PMID: 23902945
    7. The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T. PMID: 22966201
    8. human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation PMID: 15840819
    9. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described. PMID: 16157702
    10. Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies. PMID: 18343217
    11. Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality PMID: 19850929

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  • 亞細胞定位:
    Cytoplasm, P-body. Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle.
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 16687

    OMIM: 607445

    KEGG: hsa:56478

    STRING: 9606.ENSP00000328103

    UniGene: Hs.517559



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