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EIF4EBP2 Antibody

  • 中文名稱：
    EIF4EBP2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007563YA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: EIF4EBP2 antibody at 2µg/ml
      Lane 1: Mouse heart tissue
      Lane 2: NIH/3T3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 13 kDa
      Observed band size: 13 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA007563YA01HU at dilution of 1:10
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007563YA01HU at dilution of 1:10
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EIF4EBP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EIF4EBP2
  • 別名：
    4E-BP2 antibody; 4EBP2 antibody; 4EBP2_HUMAN antibody; eIF4E binding protein 2 antibody; eIF4E-binding protein 2 antibody; Eif4ebp2 antibody; Eukaryotic translation initiation factor 4E binding protein 1 antibody; Eukaryotic translation initiation factor 4E-binding protein 2 antibody; PHASII antibody; phosphorylated; heat and acid stable regulated by insulin protein II antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 2 protein (1-120AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，EIF4EBP2 Antibody (CSB-PA007563YA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于EIF4EBP2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA007563YB01HU EIF4EBP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007563YC01HU EIF4EBP2 Antibody, FITC conjugated
    Biotin CSB-PA007563YD01HU EIF4EBP2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:10-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • 基因功能參考文獻(xiàn)：
    1. molecular dynamics simulations to investigate both the folded and unfolded states of 4E-BP2 under different phosphorylation states of T37 and T46 PMID: 28068774
    2. isoaspartate formation repair modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain PMID: 20424163
    3. PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin PMID: 14507920
  • 蛋白家族：
    EIF4E-binding protein family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3289

    OMIM: 602224

    KEGG: hsa:1979

    STRING: 9606.ENSP00000362314

    UniGene: Hs.621200



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