在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF4E2 Antibody

  • 中文名稱:
    EIF4E2兔多克隆抗體
  • 貨號:
    CSB-PA007558ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA007558ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007558ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EIF4E2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    4E LP antibody; 4EHP antibody; 4ELP antibody; EIF 4E type 2 antibody; eIF-4E type 2 antibody; EIF4 E2 antibody; EIF4E 2 antibody; eIF4E family; member 2 antibody; EIF4E HOMOLOGOUS PROTEIN antibody; EIF4E like cap binding protein antibody; EIF4E like protein 4E LP antibody; EIF4E like protein 4ELP antibody; eIF4E type 2 antibody; EIF4E type 3 antibody; eIF4E-like 3 antibody; eIF4E-like protein 4E-LP antibody; EIF4E2 antibody; Eukaryotic translation initiation factor 4E family member 2 antibody; Eukaryotic translation initiation factor 4E homologous protein antibody; Eukaryotic translation initiation factor 4E like 3 antibody; Eukaryotic translation initiation factor 4E member 2 antibody; Eukaryotic translation initiation factor 4E type 2 antibody; Eukaryotic translation initiation factor 4E-like 3 antibody; IF 4e antibody; IF4E antibody; IF4E2_HUMAN antibody; mRNA cap binding protein 4EHP antibody; mRNA cap binding protein type 3 antibody; mRNA cap-binding protein 4EHP antibody; mRNA cap-binding protein type 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Eukaryotic translation initiation factor 4E type 2 protein (1-240AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression.
  • 基因功能參考文獻:
    1. cadherin-22 is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2 functioning as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion. PMID: 28991229
    2. cap-binding activity contributes to the translational silencing by miRNAs through the CCR4-NOT complex PMID: 28487484
    3. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts. PMID: 28942592
    4. miRNA enhances eIF4E2 association with the target mRNA PMID: 28755203
    5. Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules. PMID: 27578149
    6. Tristetraprolin recruits eukaryotic initiation factor 4E2 (eIF4E2) to repress target mRNA translation. PMID: 26370510
    7. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E. PMID: 25624349
    8. provide evidence that eIF4E2 binds 4E-T in the yeast two hybrid assay, as well as in pull-down assays and by recruitment to P-bodies in mammalian cells PMID: 23991149
    9. Activation of eIF4E2-directed translation is essential for cancer cells. PMID: 24408918
    10. GIGYF2 and the zinc finger protein 598 (ZNF598) are identified as components of the 4EHP complex. PMID: 22751931
    11. 4EHP over-expression instigates a negative feedback loop that inhibits upstream signaling to 4E-BP1 and ribosomal protein S6 kinase 1 (S6K1) whereas the 4E-BP1-binding-deficient mutant of 4EHP(W95A) was unable to trigger this feedback loop PMID: 15094042
    12. ISGylation of 4EHP may play an important role in cap structure-dependent translation control in immune responses. PMID: 17289916
    13. 4EHP plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from eIF4E. PMID: 17368478
    14. 4EHP binds cap analogs m(7)GpppG and m(7)GTP with low affinity PMID: 17369309

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, P-body.
  • 蛋白家族:
    Eukaryotic initiation factor 4E family
  • 數據庫鏈接:

    HGNC: 3293

    OMIM: 605895

    KEGG: hsa:9470

    STRING: 9606.ENSP00000258416

    UniGene: Hs.292026



主站蜘蛛池模板: 极品人妻被黑人中出种子| 揄拍成人国产精品视频| 国产精品交换| 亚洲国产欧美一区二区好看电影| 国产sp调教打屁股视频网站| 青青草原精品99久久精品66| 久久久久久久久久久国产| 午夜福利片手机在线播放| 俺去啦俺来也五月天| 免费人成视频| 蜜桃无码一区二区三区| 欧美亚洲国产精品久久| 久久国产超碰女女av| 日本公妇乱偷中文字幕| 国产精品a成v人在线播放| 亚洲精品色播一区二区| 色综合视频一区二区三区44| 欧美又大又色又爽aaaa片| 亚洲午夜免费福利视频| 亚洲v国产v天堂a无码二区| 久久精品无码av| 波多野结衣在线精品视频| 久久精品国产亚洲夜色av网站| 国产精品久久国产精麻豆99网站| 综合久久给合久久狠狠狠97色| 亚洲综合一区无码精品| 青草av久久一区二区三区| 亚洲乱妇亚洲乱妇xinglu| 国产精品无码免费播放| 爽死你欧美大白屁股在线| 亚洲国产成人综合在线不卡| 国产激情з∠视频一区二区| 亚洲性无码av中文字幕| 中国少妇内射xxxhd| 浴室人妻的情欲hd三级国产| 热re99久久精品国产66热| 国产亚洲精品美女在线| 国产精品无码嫩草地址更新| 麻豆国产人妻欲求不满谁演的| 久久精品亚洲男人的天堂| 人妻三级日本香港三级极97|