在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EIF3H Antibody

EIF3H Antibody

  • 中文名稱：
    EIF3H兔多克隆抗體
  • 貨號：
    CSB-PA007537ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: EIF3H antibody at 7μg/ml
      Lane 1: NIH/3T3 whole cell lysate
      Lane 2: Rat brain tissue
      Lane 3: U251whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 40 kDa
      Observed band size: 40 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA007537ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EIF3H Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    eIF-3-gamma antibody; eIF3 gamma antibody; eIF3 p40 antibody; eIF3 p40 subunit antibody; eIF3h antibody; EIF3H_HUMAN antibody; EIF3S3 antibody; Eukaryotic translation initiation factor 3 subunit 3 antibody; Eukaryotic translation initiation factor 3 subunit H antibody; MGC102958 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 3 subunit H protein (80-340AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
  • 基因功能參考文獻(xiàn)：
    1. EIF3H knockdown inhibited cell proliferation and colony formation in gastric cancer lines and led to cell cycle arrest at the G0/G1 phase, while inducing apoptosis via up- and downregulation of pro- and anti-apoptotic factors, respectively. These results indicate that EIF3H can serve as a novel therapeutic target for the clinical treatment of gastric cancer. PMID: 30060823
    2. EIF3H plays key roles in the apoptosis in colorectal cancer cells, which suggests EIF3H as a potential diagnostic biomarker in colorectal cancer PMID: 30022709
    3. eukaryotic translation initiation factor 3H has roles in proliferation, invasion and tumorigenicity in human hepatocellular carcinoma PMID: 27340783
    4. -RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells PMID: 24148822
    5. Increased expression of EIF3H gene increases colorectal cancer growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association. PMID: 20862326
    6. Gain of EIF3S3 was associated with poor cancer-specific survival in incidentally found prostate carcinomas. PMID: 11733359
    7. PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC. PMID: 14578863
    8. overexpression of EIF3S3 is associated with breast and prostate cancer PMID: 14997205
    9. results suggest that eukaryotic translation initiation factor 3, subunit 3 (EIF3S3) regulates cell growth and viability, and that overexpression of the gene may provide growth advantage to the cancer cells PMID: 16652384
    10. high eIF3h levels directly stimulate protein synthesis, resulting in the establishment and maintenance of the malignant state in cells. PMID: 18544531
    11. MYC and EIF3H are frequently coamplified in NSCLC and that a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity. PMID: 19204574

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit H family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3273

    OMIM: 603912

    KEGG: hsa:8667

    STRING: 9606.ENSP00000429931

    UniGene: Hs.492599



主站蜘蛛池模板： 国色天香网www在线观看| 极品少妇高潮到爽| 日韩精品一区二区三区| 无码精品人妻一区二区三区影院| 久久人妻少妇嫩草av无码专区| 国产成人免费ā片在线观看| 午夜影视啪啪免费体验区入口| 久久精品亚洲国产av老鸭网| 青青草国产免费久久久下载| 欧美熟妇色ⅹxxx欧美妇| 国产精品18久久久久久vr| 日本丰满少妇xxxx| 亚洲精品欧美精品日韩精品| 国产福利一区二区麻豆| 国产乱xxⅹxx国语对白| 久久大香香蕉国产| 久久久久久亚洲精品成人| 中文字幕精品久久久久人妻红杏| 蜜臀av性久久久久蜜臀aⅴ| 10000部拍拍拍免费视频| 四虎国产精品亚洲一区久久特色| 欧美性猛交xxxx乱大交丰满| 免费无码成人av电影在线播放| 亚洲国产日韩制服在线观看 | 级r片内射在线视频播放| 国产爆乳无码视频在线观看 | 日本老熟妇乱子伦视频| 2020久热爱精品视频在线观看| 亚洲中文字幕无码久久2017| 大肉大捧一进一出好爽动态图| 老司机性色福利精品视频| 三级做爰高清视频| 婷婷亚洲综合五月天小说| 亚洲熟妇无码乱子av电影| 国内精品久久久久影视| 国产成人久久久精品二区三区| 三个男吃我奶头一边一个视频| 吃奶呻吟打开双腿做受在线视频 | 亚洲欧美在线观看品| 色妺妺视频网| 人妻中文无码久热丝袜|