在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EIF3F Antibody

EIF3F Antibody

  • 中文名稱：
    EIF3F兔多克隆抗體
  • 貨號：
    CSB-PA002303
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Jurkat cells using eIF3ε Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    EIF3F
  • 別名：
    Deubiquitinating enzyme eIF3f antibody; eIF 3 epsilon antibody; eIF-3-epsilon antibody; eIF3 p47 antibody; eIF3 p47 subunit antibody; eIF3-epsilon antibody; eIF3-p47 antibody; eIF3f antibody; EIF3F_HUMAN antibody; EIF3S5 antibody; EIF3S5; formerly antibody; Eukaryotic translation initiation factor 3 subunit 5 antibody; Eukaryotic translation initiation factor 3 subunit 5; formerly antibody; Eukaryotic translation initiation factor 3 subunit F antibody; eukaryotic translation initiation factor 3; subunit 5 (epsilon; 47kD) antibody; eukaryotic translation initiation factor 3; subunit 5 epsilon; 47kDa antibody; eukaryotic translation initiation factor 3; subunit F antibody; translation initiation factor 3 47 kda subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human eIF3ε.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
  • 基因功能參考文獻：
    1. The overexpression of eIF3f suppressed Akt and ERK signaling and subsequently depleted CLU expression. In addition, eIF3F stabilized p53, which increased the expression of p21 and Bax. PMID: 26988917
    2. eIF3f/alpha adrenergic receptor interaction PMID: 26497985
    3. Decreased expression of eukaryotic initiation factor 3f is associated with gastric cancer. PMID: 24678890
    4. eIF3f may play an important role in recurrence. PMID: 24732644
    5. findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation PMID: 22457825
    6. catalytically inactive forms of eIF3f as well as shRNAs targeting eIF3f repress Notch activation in a coculture assay, showing that eIF3f is a new positive regulator of the Notch pathway PMID: 21124883
    7. Loss of EIF3F in pancreatic cancer is reported. PMID: 17918192
    8. demonstrated a statistically significant decrease of the eIF3f gene copy number in melanoma compared with normal tissues with a tumor/normal ratio of 0.52 PMID: 18381585
    9. eIF3f specifically interferes with the 3' end processing of HIV-1 mRNAs PMID: 19237569
    10. eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis. PMID: 19245811
    11. eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit F family
  • 數據庫鏈接：

    HGNC: 3275

    OMIM: 603914

    KEGG: hsa:8665

    STRING: 9606.ENSP00000310040

    UniGene: Hs.516023



主站蜘蛛池模板： 亚洲人成色77777在线观看| 久久九九精品国产av片国产| 小草国产精品情侣| 人妻少妇精品无码专区app| 国产精品久久久久久吹潮| 亚洲欧美日韩成人综合一区| 在线观看的av免费网站| 中文字幕无码精品亚洲资源网久久| 国产色婷婷亚洲99精品小说 | 国产精品人妻一码二码尿失禁| 国内偷自第一区二区三区| 欧美成人精品 一区二区三区| 日本中文一区二区三区亚洲| 大地资源在线观看官网第三页| 无码专区一va亚洲v专区在线| 97一区二区国产好的精华液| 免费va国产高清大片在线| 日日噜噜夜夜狠狠va视频| 久久婷婷人人澡人人爽人人爱 | 国产色播av在线观看| 熟妇无码熟妇毛片| 国产欧美一区二区三区免费视频| 日韩精品区一区二区三vr| 午夜好爽好舒服免费视频| 天天爱天天做久久狼狼| 色老板精品视频在线观看| 女人被狂躁c到高潮喷水电影| 亚洲一线产区二线产区分布| 欧美日韩国产精品| 国产成人无码综合亚洲日韩| 欧美又大又粗午夜剧场免费| 日韩欧美偷拍高跟鞋精品一区| 国产乱沈阳女人高潮乱叫老| 国产sm主人调教女m视频| 在线 亚洲 国产 欧美| 大尺度无遮挡激烈床震网站| 黑鬼大战白妞高潮喷白浆| 国产精品毛片完整版视频| 亚洲欧美中文日韩v在线97| 狠狠色综合tv久久久久久| 免费视频爱爱太爽了|