在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF2AK1 Antibody, Biotin conjugated

  • 中文名稱(chēng):
    EIF2AK1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA007510LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) EIF2AK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    E2AK1_HUMAN antibody; EC 2.7.11.1 antibody; Eif2ak1 antibody; Eukaryotic translation initiation factor 2 alpha kinase 1 antibody; Eukaryotic translation initiation factor 2-alpha kinase 1 antibody; HCR antibody; Heme controlled repressor antibody; Heme regulated eukaryotic initiation factor eIF 2 alpha kinase antibody; Heme regulated inhibitor antibody; Heme regulated initiation factor 2 alpha kinase antibody; Heme regulated repressor antibody; Heme sensitive initiation factor 2a kinase antibody; Heme-controlled repressor antibody; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase antibody; Heme-regulated inhibitor antibody; Hemin sensitive initiation factor 2 alpha kinase antibody; Hemin-sensitive initiation factor 2-alpha kinase antibody; HRI antibody; KIAA1369 antibody; PRO1362 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 1 protein (1-86AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions. Also activates the ISR in response to mitochondrial dysHRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming.
  • 基因功能參考文獻(xiàn):
    1. Activation of HRI is mediated by Hsp90 during stress through modulation of the HRI-Hsp90 complex PMID: 30170366
    2. Taken together, these results suggest HRI as a potential therapeutic target for hemoglobinopathies. PMID: 30026227
    3. data suggests that glutamatergic stimulation induces HRI activation by NO to trigger GluN2B expression and this process would be relevant to maintain postsynaptic activity in cortical neurons PMID: 27557499
    4. The antiviral kinase PKR plays a critical role in controlling HCMV replication. PMID: 27974558
    5. structural and functional stability of HRI PMID: 27888007
    6. Infection-associated functions of HRI (an eIF2alpha kinase) are independent of its activity as a regulator of protein synthesis. PMID: 23874749
    7. During lead-stress, the regulation of hHRI mRNA translation is mediated through its 5'-untranslated region (UTR) that interacts with specific trans-acting factors. PMID: 23357686
    8. Dephosphorylation of eIF2alpha, specifically in the cortex, is both correlated with and necessary for normal memory consolidation. PMID: 23392680
    9. eukaryotic initiation factor 2alpha kinase is a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. PMID: 20071449
    10. autophosphorylation of Thr485 is essential for the hyperphosphorylation and activation of HRI and is required for the acquisition of the eIF2alpha kinase activity PMID: 12767237
    11. These data establish for the first time, the possible mechanisms of regulation of hHRI gene expression under normal physiological condition, hemin exposure and stress. PMID: 19133234

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
  • 組織特異性:
    Expressed predominantly in erythroid cells. Expressed at much lower levels in hepatocytes (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 24921

    KEGG: hsa:27102

    STRING: 9606.ENSP00000199389

    UniGene: Hs.520205



主站蜘蛛池模板: 少妇无码一区二区三区| 久久久久久无码午夜精品直播| 国产一线二线三线女| 成年美女黄网站色大免费全看| 先锋影音最新色资源站| 人妻丰满熟妇av无码区hd| 欧美嫩交一区二区三区| 日本无码一区二区三区不卡免费| 亚洲精品乱码久久久久久v| 日本sm/羞辱/调教/捆绑视频| 国产免费啪嗒啪嗒视频看看| h人成在线看免费视频| 亚洲成a人片在线观看无码| 荡女精品导航| 亚洲成av人片在www| 成人午夜福利免费体验区| 精品久久香蕉国产线看观看亚洲| 久久久久女教师免费一区| 久久久精品久久久久久96| 67194熟妇人妻欧美日韩| 一边吃奶一边做动态图| 日本妇人成熟免费| 两性色午夜视频免费播放| 亚洲s久久久久一区二区| 欧美精品国产综合久久| 无码人妻一区二区三区在线视频| 国产精品无码av在线一区| 久久久久久好爽爽久久| 妺妺窝人体色www婷婷| 在线无码中文字幕一区| 午夜福利午夜福利1000| 久久久噜噜噜www成人网| 蜜桃视频网站| 久久精品aⅴ无码中文字字幕不卡| av中文无码韩国亚洲色偷偷| 欧美黑人又大又粗xxxxx| 国产精品国产亚洲区艳妇糸列短篇| 中文字幕在线不卡精品视频99 | 2020精品国产午夜福利在线观看| 手机真实国产乱子伦对白视频| 大陆熟妇丰满多毛xxxx|