在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF1AX Antibody

  • 中文名稱:
    EIF1AX兔多克隆抗體
  • 貨號:
    CSB-PA007506GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    EIF1AX antibody; EIF1A antibody; EIF4C antibody; Eukaryotic translation initiation factor 1A antibody; X-chromosomal antibody; eIF-1A X isoform antibody; Eukaryotic translation initiation factor 4C antibody; eIF-4C antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human EIF1AX
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
  • 基因功能參考文獻:
    1. Its mutation is found in patients with meningeal melanocytic tumor. PMID: 29476293
    2. Study identified a new RNA-induced silencing complex component, eIF1A, which directly interacts with the MID-domain of Ago2 and functions in DICER-independent miRNA biogenesis and miRNA-mediated RNA interference. PMID: 29236257
    3. EIF1AX alterations occurred infrequently in low-grade gliomas (1.4%), uterus endometrial carcinoma (1.25%), thyroid carcinoma (1%), and lung adenocarcinoma (0.4%). PMID: 27089234
    4. In this report we show that patients with uveal melanoma harbor mutation-specific chromosomal patterns in the tumor. These chromosomal patterns are characterized by different types of chromosomal anomalies, thus illustrating that distinct biological mechanisms underlie uveal melanoma pathogenesis. PMID: 27916271
    5. Coexpression of mutant NRAS and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer. PMID: 28646021
    6. Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor 1A (eIF1A) which interacts with both RPS3 and RPS10e. PMID: 28584194
    7. Mutation in EIF1AX gene is associated with Uveal Melanoma. PMID: 28810145
    8. we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11, and EIF1AX mutations. PMID: 28700778
    9. results indicate that the interactions between eIF1A and eIF5B are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments PMID: 27325746
    10. Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1, SF3B1, or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1-mutated tumors are associated with late metastasis PMID: 26923342
    11. BAP1, SF3B1, and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk. PMID: 27123562
    12. We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules. PMID: 26911375
    13. The finding of this study suggested that an SF3B1 or EIF1AX mutation is present in a substantial subset of primary LMNs underscores that these tumors genetically resemble uveal melanoma and are different from cutaneous melanoma at the genetic level. PMID: 26769193
    14. The effect of an EIF1AX mutation is estimated to be a decreased odds of metastasis in uveal melanoma. PMID: 24970262
    15. the newly identified driver mutations in EIF1AX and SF3B1, specifically found in uveal melanomas with disomy 3, confirm and extend the established classification model of uveal melanoma. PMID: 23793026
    16. Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex PMID: 23293029
    17. eIF3j/HCR1 closely cooperates with the eIF3b/PRT1 RNA recognition motif and eIF1A on the ribosome to ensure proper formation of the scanning-arrested conformation required for stringent AUG recognition PMID: 20060839
    18. Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers. PMID: 11699879
    19. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. PMID: 12426392
    20. determination of binding site on eukaryotic initiation factor 5B PMID: 12569173
    21. The efficiency of the EF-1alpha promoter was higher than that of the cytomegalovirus promoter in all embryonic stem cells trnasfected. PMID: 17784828

    顯示更多

    收起更多

  • 蛋白家族:
    EIF-1A family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3250

    OMIM: 300186

    KEGG: hsa:107984923

    STRING: 9606.ENSP00000368927

    UniGene: Hs.522590



主站蜘蛛池模板: 天天av天天爽无码中文| 综合五月激情二区视频| 亚洲人成网站18禁止无码| 久久久成人精品av四区| 国产精品久久久久久爽爽爽床戏| 夜夜躁狠狠躁日日躁2022| 欧美 日韩 国产 亚洲 色| 亚洲精品国产精品乱码视色| 精品久久久久久久久午夜福利| 久久久肥妇熟女ⅹxxx毛片| 成人久久久久久久久久久| 日本护士毛茸茸高潮| 久久精品国产曰本波多野结衣 | 97性无码区免费| 新香蕉少妇视频网站| av在线观看地址| 久久婷婷五月综合色和| 亚洲最大无码中文字幕网站| 中文字幕av免费专区| 日本大乳高潮视频在线观看| 精品无码中文字幕在线| 日本亚洲欧美综合在线| 绝顶高潮合集videos| 男女免费观看做爰视频在线观看| 18禁超污无遮挡无码免费网站国产 | 国产精品秘入口18禁麻豆免会员 | 国产卡一卡二卡三精品| 无码日韩人妻精品久久蜜桃| 天堂а√在线官网| 午夜福利视频一区二区手机免费看| av天堂亚洲区无码先锋影音| 亚洲爆乳大丰满无码专区| 精品蜜臀av在线天堂| 欧美日韩视频在线第一区| 精品亚洲成a人在线观看| 欧美两根一起进3p做受视频| 无码国模大尺度视频在线观看| 日产精品久久久久久久 | 久久综合一色综合久久小蛇| 日本一丰满一bbw| 国产精品偷窥熟女精品视频|