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  4. EID1 Antibody

EID1 Antibody

  • 中文名稱：
    EID1兔多克隆抗體
  • 貨號：
    CSB-PA002286
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using EID-1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    EID1
  • 別名：
    21 kDa pRb associated protein antibody; 21 kDa pRb-associated protein antibody; C15orf3 antibody; CBP antibody; Chromosome 15 open reading frame 3 antibody; CREBBP/EP300 inhibitor 1 antibody; CREBBP/EP300 inhibitory protein 1 antibody; CRI 1 antibody; CRI1 antibody; E1A like inhibitor of differentiation antibody; E1A-like inhibitor of differentiation 1 antibody; EID 1 antibody; EID-1 antibody; EID1 antibody; EID1_HUMAN antibody; EP300 interacting inhibitor of differentiation 1 antibody; EP300-interacting inhibitor of differentiation 1 antibody; IRO45620 antibody; MGC138883 antibody; MGC138884 antibody; NB4 apoptosis related protein antibody; PNAS 22 antibody; PNAS22 antibody; PTD014 antibody; Rb and p300 binding protein EID 1 antibody; Rb and p300 binding protein EID1 antibody; RBP21 antibody; Retinoblastoma protein associated protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human EID-1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
  • 基因功能參考文獻：
    1. EID1 can modulate adipose mesenchymal stem cells, inducing a brown/beige lineage. PMID: 26643909
    2. Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation. PMID: 24167073
    3. An unexpected EID1-binding site on SHP is located at the N terminus of the receptor, where EID1 mimics helix H1 of the nuclear receptor ligand-binding domain. PMID: 24379397
    4. This study demonstrated that overexpression of EID1 reduced hippocampal long-term potentiation and impaired spatial learning and memory function in the transgenic mice PMID: 22186421
    5. miR-138 inhibited adipogenesis through targeting the nuclear receptor coregulator EID-1 PMID: 20486779
    6. The role of EID1 in fibroblast biology and fibrosis is reported. PMID: 17559085
    7. Repression of E6 and E7 oncogenes results in restoration of pRb suppressor pathways and induced apoptosis in HPV16-positive oropharyngeal squamous cell cancer cell lines. PMID: 19276448

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and vari
  • 數據庫鏈接：

    HGNC: 1191

    OMIM: 605894

    KEGG: hsa:23741

    STRING: 9606.ENSP00000431162

    UniGene: Hs.255973



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