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  4. EFNB3 Antibody

EFNB3 Antibody

  • 中文名稱：
    EFNB3兔多克隆抗體
  • 貨號：
    CSB-PA007467ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007467ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EFNB3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EFNB3
  • 別名：
    EFL 6 antibody; EFL6 antibody; EFNB 3 antibody; Efnb3 antibody; EFNB3_HUMAN antibody; EPH related receptor transmembrane ligand ELK L3 antibody; EPH related receptor transmembrane ligand ELKL3 antibody; EPH related receptor tyrosine kinase ligand 8 antibody; EPH-related receptor transmembrane ligand ELK-L3 antibody; EPH-related receptor tyrosine kinase ligand 8 antibody; Ephrin B3 antibody; Ephrin-B3 antibody; EphrinB3 antibody; EPLG 8 antibody; EPLG8 antibody; LERK 8 antibody; LERK-8 antibody; LERK8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ephrin-B3 protein (28-226AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.; (Microbial infection) Acts as a receptor for nipah virus and hendra virus.
  • 基因功能參考文獻：
    1. The study provides evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrating that EFNB3 is a hypertension risk gene. PMID: 28272517
    2. Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation. PMID: 27941904
    3. Data show that Ephrin B3 was concomitantly expressed with EphA2 and Ephrin A1 with higher Ephrin B3 levels found in non-squamous than in squamous tumors. PMID: 27533087
    4. Study found up-regulated expression of ephrinB3/EphB3 in intractable temporal lobe epilepsy patients and experimental temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3 might be involved in the pathogenesis of temporal lobe epilepsy PMID: 26930615
    5. Findings suggest that EphrinB3 may be a relevant target for promoting remyelination in demyelinating disease PMID: 26687980
    6. Ephrin-B3 binds to B lymphocytes, most likely via a non-classical receptor, and induces migration of the memory B cell subpopulation. PMID: 21447033
    7. Phosphoproteomic profiling of nonsmall cell lung cancer cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. PMID: 21413766
    8. evidence for an unknown ephrin-B3-binding cell-surface proteoglycan involved in cellular signalling PMID: 20925654
    9. EphrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G-H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity. PMID: 16477309
    10. Immunohistochemistry shows robust staining for phosphorylated ephrin-B and ephrin-B3 in invading glioblastoma cells. PMID: 16951161
    11. Transgenic EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus PMID: 18057206
    12. report the crystal structures of the NiV-G both in its receptor-unbound state and in complex with ephrin-B3, providing, to our knowledge, the first view of a paramyxovirus attachment complex in which a cellular protein is used as the virus receptor PMID: 18632560

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Ephrin family
  • 組織特異性：
    Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
  • 數據庫鏈接：

    HGNC: 3228

    OMIM: 602297

    KEGG: hsa:1949

    STRING: 9606.ENSP00000226091

    UniGene: Hs.26988



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