在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EFNA5 Antibody

EFNA5 Antibody

  • 中文名稱：
    EFNA5兔多克隆抗體
  • 貨號：
    CSB-PA977329
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA977329(EFNA5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA977329(EFNA5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    EPLG7 antibody; AF1 antibody; AL 1 antibody; AL-1 antibody; EFL5 antibody; Efna5 antibody; EFNA5_HUMAN antibody; EPH-related receptor tyrosine kinase ligand 7 antibody; Ephrin A5 antibody; Ephrin-A5 antibody; EPLG7 antibody; GLC1M antibody; LERK-7 antibody; LERK7 antibody; RAGS antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human EFNA5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
  • 基因功能參考文獻(xiàn)：
    1. These results indicate a novel mechanism of ephrin-Eph signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2(+) extracellular vesicles in neural development and synapse physiology. PMID: 27354374
    2. MiR-96 and miR-182 are upregulated in hepatocellular carcinoma and negatively associated with ephrin A5 expression. PMID: 25663355
    3. the structure of the ligand-binding domain of the EphA3 receptor in complex with its preferred ligand, ephrin-A5, is reported. PMID: 25993310
    4. The genetic variations c.668C>T (rs201008479), c.102C>T (rs199980747) and c.-27C>G (rs200187971) may present an additional genetic risk factor for age-related cataract in the Chinese population. PMID: 25300504
    5. Data indicate that ephrin-A5 binding directly facilitates the formation of Eph/ephrin clusters by inducing conformational changes in the ligand-binding domain (LBD) of EphA4. PMID: 23959867
    6. Transgenic ephrin-A5 plays a critical role in postnatal lens fiber organization to maintain lens transparency: cells in the ephrin-A5-deficient lens are severely disorganized PMID: 23401654
    7. EphrinA5, especially ephrinA5S, acts as a tumor suppressor in hepatocarcinogenesis. PMID: 22860012
    8. This study presented that EFNA5 showed strong associations with alcohol withdrawal symptoms. PMID: 22072270
    9. Data suggest that ephrinA5 mRNA/protein levels are reduced in colon adenocarcinoma compared to normal colon tissue; staging/grading indicates that ephrinA5 inhibits colon adenocarcinoma progression via c-Cbl-mediated EGFR ubiquitination/degradation. PMID: 22074469
    10. ephrin-A5-induced cell-morphologic changes of EphA3-positive LK63 pre-B acute lymphoblastic leukemia cells PMID: 18385452
    11. These observations indicate that only a subset of signal transduction pathways is required for ephrin-A5-induced growth cone collapse. PMID: 18563700
    12. ephrinA5 acted as a tumor suppressor in glioma, and its negative regulation of EGFR contributed to the suppressive effects. PMID: 19270726
    13. EFNA5 down-regulation is a consistent finding in chondrosarcomas PMID: 19695673

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane, caveola; Lipid-anchor, GPI-anchor. Note=Compartmentalized in discrete caveolae-like membrane microdomains.
  • 蛋白家族：
    Ephrin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3225

    OMIM: 601535

    KEGG: hsa:1946

    STRING: 9606.ENSP00000328777

    UniGene: Hs.288741



主站蜘蛛池模板： 成人精品免费视频在线观看| 天天干天天日| 风韵人妻丰满熟妇老熟女| 欧美xxxxx在线观看| 亚洲熟妇无码av不卡在线播放 | 亚洲熟女精品中文字幕| 中文av伊人av无码av狼人| 午夜嘿嘿嘿影院| 欧美精品久久天天躁| 97碰碰碰免费公开在线视频| 国产美女被遭高潮免费网站| 久久精品无码av| 99精品偷自拍| 中文午夜乱理片无码| 国产高清av喷水白丝护士| 国产乱人伦无无码视频试看| 成人做爰www网站视频| 国产成人综合在线女婷五月99播放| 13小箩利洗澡无码视频网站| 国产偷窥熟妇高潮呻吟| 久久久久久毛片免费播放| 最新亚洲精品国偷自产在线 | 午夜射精日本三级| 极品美女在线观看免费直播| 97精品尹人久久大香线蕉| 日日噜噜噜噜夜夜爽亚洲精品| 日日鲁鲁鲁夜夜爽爽狠狠| 亚洲中文字幕伊人久久无码| 亚洲综合色视频在线观看| 娇妻玩4p被三个男人伺候电影| 四虎国产精亚洲一区久久特色| 丰满少妇被猛烈进入av久久| 亚洲国产精品久久久久婷婷老年| 88国产精品欧美一区二区三区| 一本天堂v无码亚洲道久久| 热久久视久久精品18| 欧美色综合天天久久综合精品| 久久99精品国产自在现线小黄鸭| 久久人人97超碰caoporen| 67194成是人免费无码| 中国xxxx做受视频|