在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EFEMP2 Antibody, FITC conjugated

  • 中文名稱:
    EFEMP2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA007451LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EFEMP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EFEMP2
  • 別名:
    EFEMP 2 antibody; EFEMP2 antibody; EGF containing fibulin like extracellular matrix protein 2 antibody; EGF-containing fibulin-like extracellular matrix protein 2 antibody; FBLN 4 antibody; FBLN4 antibody; FBLN4_HUMAN antibody; FIBL 4 antibody; FIBL-4 antibody; FIBL4 antibody; Fibulin 4 antibody; Fibulin-4 antibody; MBP 1 antibody; MBP1 antibody; Mutant p53 binding protein 1 antibody; Protein UPH1 antibody; UPH 1 antibody; UPH1 antibody; UPH1 protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human EGF-containing fibulin-like extracellular matrix protein 2 protein (26-165AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.
  • 基因功能參考文獻:
    1. different mutations in the fibulin-4 gene result in different molecular defects affecting secretion rates, protein stability, LOX-induced cross-linking, or binding to other ECM components and molecules of the TGF-beta pathway. PMID: 27339457
    2. the expression of fibulin-4 was negatively correlated with the malignant phenotype of endometrial cancer cells. Fibulin-4 may have the ability to suppress endometrial cancer cell invasion and proliferation PMID: 28177909
    3. The results revealed that fibulin-4 expression was upregulated in osteosarcoma, and was positively correlated with low differentiation, lymph node metastasis, and poor prognosis. Fibulin-4 was also found to be over-expressed in highly invasive cell lines and in the highly invasive subclones PMID: 28339091
    4. Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase which has a pivotal role in cross-linking of collagen and elastin. PMID: 26690653
    5. Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features. PMID: 25885889
    6. pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice PMID: 25255451
    7. Homozygous mutations in exon 7 of the FBLN4 gene can produce lethal vasculopathy. PMID: 24838734
    8. This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma. PMID: 24737201
    9. The expression level of EFEMP2 is dramatically increased in colorectal cancer patients, even at the early stage, compared with healthy controls. PMID: 22506683
    10. Studied Fibulin-4 expression in aortic wall to find out its role in aortic dissection development. Used samples of aortic wall from 10 patients operated for acute ascending aortic dissection and five patients for chronic ascending aortic dissection. PMID: 23518852
    11. A lethal, genetic disorder characterized by severe deformation of elastic arteries, was linked to novel mutations in the FBLN4 gene. PMID: 22943132
    12. Low EFEMP2 expression is associated with malignant pleural mesothelioma. PMID: 23313295
    13. EFEMP2 is a novel PITX2-interacting protein that may bear importance for the development of anterior segment dysgenesis (ASD) and glaucoma. PMID: 22919265
    14. FBLN4 has 10 coding exons PMID: 22070778
    15. In this largest cohort of reported patients with a mutated EFEMP2 gene, we illustrate the phenotypic spectrum of inherited AA due to a novel EFEMP2 mutation. PMID: 22440127
    16. patients with recessive FBLN4 mutations are predominantly characterized by aortic aneurysms, arterial tortuosity and stenosis; evidence for the involvement of altered TGFbeta signaling in the pathogenesis of FBLN4 mutations PMID: 20389311
    17. Fibulin-4, expressed in chondrocytes and recognized as an autoantigen mainly in osteoarthritis (OA) rather than in rheumatoid arthritis, may play pathogenic roles in OA. PMID: 16493080
    18. Fibulin-4, considered as a structural protein, may also participate in regulating elastic-fibre formation in human cells through the regulation of tropoelastin expression. PMID: 19627254

    顯示更多

    收起更多

  • 相關疾病:
    Cutis laxa, autosomal recessive, 1B (ARCL1B)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane.
  • 蛋白家族:
    Fibulin family
  • 數據庫鏈接:

    HGNC: 3219

    OMIM: 604633

    KEGG: hsa:30008

    STRING: 9606.ENSP00000309953

    UniGene: Hs.731454



主站蜘蛛池模板: 香蕉欧美成人精品a∨在线观看| 欧美亚洲另类 丝袜综合网| 国产精品免费观看调教网| 亚洲精品久久国产高清小说| 在线精品视频一区二区三四 | 欧美s码亚洲码精品m码| 老熟女 露脸 嗷嗷叫| 亚洲日韩高清在线亚洲专区| 女人高潮抽搐潮喷视频开腿| 亚洲国产精品一区二区制服| 老熟女重囗味hdxx70星空| 免费国精产品自偷自偷免费看| 久久www香蕉免费人成| 欧洲日本一线二线三线区本庄铃| 国产多人群p刺激交换视频| 国产精品福利视频导航| 一女被多男玩喷潮视频| 国产伦子系列沙发午睡| 9999国产精品欧美久久久久久| 亚洲国产av导航第一福利网| 无码人妻精品一区二区蜜桃色欲| 中国凸偷窥xxxx自由视频妇科 | 久久久久免费看成人影片| 人人爽久久久噜噜噜婷婷| 国产杨幂av在线播放| 国产乱人无码伦av在线a | 2021无码天堂在线| 国产成人精品一区二区三区| 亚洲一区 日韩精品 中文字幕| 欧美亚洲国产精品久久| 成人免费午夜无码视频| 国产av熟女一区二区三区| 人人妻人人澡人人爽欧美一区九九 | 中国凸偷窥xxxx自由视频妇科| 一边啪啪的一边呻吟声口述| 97人人超碰国产精品最新| 亚洲自偷自拍熟女另类| 精品一区二区三区东京热| 玩弄了裸睡少妇人妻野战| 亚洲成av人片在线观看高清| a国产一区二区免费入口|