在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EEF2 Antibody

  • 中文名稱:
    EEF2兔多克隆抗體
  • 貨號:
    CSB-PA090786
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA090786(EEF2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: LoVo cells, HepG2 cells, MCF7 cells, Primary antibody: CSB-PA090786(EEF2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    EEF 2 antibody; Eef2 antibody; EF-2 antibody; EF2 antibody; EF2_HUMAN antibody; Elongation factor 2 antibody; Eukaryotic translation elongation factor 2 antibody; Polypeptidyl tRNA translocase antibody; SCA26 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human EEF2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
  • 基因功能參考文獻:
    1. our study indicates that expression of eEF2 protein is a potential biomarker for evaluating prostate cancer PMID: 28913610
    2. eEF2 may be activated in a positive feedback cycle through inactivation of eEF2K via the PI3K/Akt/mTOR pathway. PMID: 30060827
    3. the direct interaction of AKT2 and EF2 was found to be dynamically regulated in embryonic rat cardiomyocytes PMID: 23823123
    4. These results suggest that binding of eEF2 to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A and impairment of this interplay compromises cell growth due to translation elongation defects. PMID: 27115996
    5. nuclear localization of active eEF-2 depends upon its interaction with p53, as cells lacking p53 contain less active eEF-2 in the nuclear compartment PMID: 23542375
    6. High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer. PMID: 24377563
    7. Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth. PMID: 24589652
    8. The expression levels of three putative HA-regulated proteins (TALDO, ANXA1 and EF2) in control, H2O2-, HA- and HA/H2O2-treated OA chondrocytes were verified by Western blotting and the results indeed support the notion that HA acts in anti-oxidation PMID: 24480285
    9. Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death. PMID: 24167567
    10. A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia 26. PMID: 23001565
    11. EEF2 phosphorylation by cyclin A-cyclin-dependent kinase 2 (CDK2) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K. PMID: 23184662
    12. Burn induces prolonged activation of eEF2K and eEF2 in pediatric patients. PMID: 22269896
    13. PHD2 modulated eEF2 activity and protein translation under acute hypoxia. PMID: 22308030
    14. NH125 induces eEF2 phosphorylation (peEF2) through multiple pathways in cancer cells PMID: 22020937
    15. Training in the fasted state, compared with identical training with ample carbohydrate intake, facilitates post-exercise dephosphorylation of eEF2. PMID: 21132439
    16. results suggest that eEF2 is an anti-apoptotic marker in lung adenocarcinoma PMID: 21554491
    17. eEF-2 is activated by both lithium and GSK-3, whereas, lithium treatment and inhibition of GSK-3 have opposing effects on eEF-2. PMID: 20708687
    18. melanoma antigen expressed in G361, a representative melanoma cell line/ reacted with autoantibodies in patient sera PMID: 20181627
    19. inhibition of protein synthesis under high pressure occurs independent of the phosphorylation of eEF-2 PMID: 15534876
    20. Levels of p-eEF2K were significantly increased, and total eEF2 significantly decreased in Alzheimer disease PMID: 16098202
    21. Data show that overproduction of elongation factor 2 blocks HIV-1 viral protein R-induced cell death both in fission yeast and human cells. PMID: 16520893
    22. Hypoxia inhibits protein synthesis through a 4EBP1 and EEF2 pathway controlled by mTOR and unbcoupled in breast cancer cells. PMID: 16648488
    23. Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber type. PMID: 19036825
    24. Overexpressed eEF2 in gastrointestinal cancers promoted G2/M progression and enhanced their cell growth in vitro and in vivo. PMID: 19360331

    顯示更多

    收起更多

  • 相關疾病:
    Spinocerebellar ataxia 26 (SCA26)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
  • 數據庫鏈接:

    HGNC: 3214

    OMIM: 130610

    KEGG: hsa:1938

    STRING: 9606.ENSP00000307940

    UniGene: Hs.515070



主站蜘蛛池模板: 亚洲日韩av片在线观看| 亚洲午夜国产精品无码老牛影视| 风流老熟女一区二区三区| 国产精品成人嫩草影院| 三个男人躁我一个爽视频免费| 国产无吗一区二区三区在线欢| 精品国产美女福到在线不卡 | 久久久精品人妻一区二区三区蜜桃| 香港三日本8a三级少妇三级99| 国产女人与公拘交在线播放| 麻豆人妻无码性色av专区 | 久久久久人妻精品一区三寸蜜桃| 97人妻人人做人碰人人爽| 老司机深夜18禁污污网站| 2021国产精品成人免费视频| 无码无套少妇毛多18pxxxx| 国产成人vr精品a视频| 综合自拍亚洲综合图区欧美| 亚洲国产精品久久久久秋霞小| 国产午夜片无码区在线播放| 中国熟妇牲交视频| 做性久久久久久| 乱精品一区字幕二区| 日韩毛片在线视频x| 成人亚欧欧美激情在线观看| 欧美天天拍在线视频| 国产suv精品一区二区62| 久久综合九色综合欧美狠狠| 中文成人无码精品久久久动漫| 国产真实的和子乱拍在线观看| 欧美国产国产综合视频| 久久久噜噜噜久久熟女aa片| 2021亚洲国产成a在线| 久久精品国产导航| 亚洲欧美日韩成人综合网 | 国产精品一区二区高清在线| 99精品偷自拍| 国产aⅴ精品一区二区三区尤物| 他掀开裙子把舌头伸进去添视频| 日日摸日日碰人妻无码老牲| 中文乱码人妻系列一区|