在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EEF1A2 Antibody

  • 中文名稱:
    EEF1A2兔多克隆抗體
  • 貨號:
    CSB-PA007412ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: EEF1A2 antibody at 2.23µg/ml
      Lane 1: MCF-7 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: Raji whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007412ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EEF1A2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EEF1A2
  • 別名:
    eEF1A-2 antibody; Eef1a2 antibody; EEF1AL antibody; EF 1 alpha 2 antibody; EF-1-alpha-2 antibody; EF1A antibody; EF1A2_HUMAN antibody; Elongation factor 1 A 2 antibody; Elongation factor 1 alpha antibody; Elongation factor 1 alpha 2 antibody; Elongation factor 1-alpha 2 antibody; Eukaryotic elongation factor 1 A-2 antibody; Eukaryotic translation elongation factor 1 alpha 2 antibody; FLJ41696 antibody; HS1 antibody; OTTHUMP00000031776 antibody; Statin like antibody; Statin S1 antibody; Statin-S1 antibody; STN antibody; STNL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Elongation factor 1-alpha 2 protein (184-463AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
  • 基因功能參考文獻:
    1. The overexpression of EEF1A2 is a frequent event in localized prostate cancer and is associated with histopathology features and a shorter biochemical recurrence-free survival. Due to its independence from serum PSA levels, EEF1A2 could serve as valuable biomarker in risk-stratification of localized prostate cancer PMID: 28923030
    2. We report a pair of siblings carrying a homozygous missense mutation p.P333L in EEF1A2 who exhibited global developmental delay, failure to thrive, dilated cardiomyopathy and epilepsy, ultimately leading to death in early childhood. EEF1A2 appears to be critical for normal heart function in humans, and its deficiency results in clinical abnormalities in neurologic function as well as in skeletal and cardiac muscle defects PMID: 28911200
    3. eEF1A2 is highly expressed in hepatocellular carcinoma. Its silencing significantly decreases HCC tumorigenesis, likely by inhibiting PI3K/Akt/NF-kappaB signaling. PMID: 27122673
    4. Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples. PMID: 27082702
    5. In both cases, a de novo recurrent heterozygous mutation in EEF1A2 [c.364G>A (p.E122K)] was identified by whole-exome sequencing. CONCLUSION: This report provides clinical data on epileptic encephalopathy in patients with EEF1A2 mutation. Continuous high-voltage delta activity seen over both parietal areas may be a unique manifestation of EEF1A2 mutation. PMID: 26682508
    6. By directly targeting eEF1A2. PMID: 25744894
    7. Both eEF1A1 and eEF1A2 colocalise with all eEF1B subunits, in such close proximity that they are highly likely to be in a complex. PMID: 25436608
    8. De novo EEF1A2 mutations in patients with characteristic facial features, intellectual disability, autistic behaviors and epilepsy. PMID: 24697219
    9. Finally, a strong association between the expression of EEF1A2, phosphorylated AKT and MDM4 was observed in human HCC samples. Strong activation of the EEF1A2/PI3K/AKT/mTOR/MDM4 signaling pathway was observed in HCC patients PMID: 25394965
    10. Overexpression of eEF1A2 was correlated with worse outcomes in gastric cancer patients, suggesting its critical roles in the carcinogenesis of gastric cancer. PMID: 25601347
    11. miR-663 and miR-744 mediate inhibition of the proto-oncogene eEF1A2 expression that results in retardation of the MCF7 cancer cells proliferation. We also observed upregulation of miR-663 and miR-744 with corresponding downregulation of eEF1A2 in resveratrol-treated MCF7 cells, suggesting that resveratrol may influence eEF1A2 expression through a miRNA-dependent pathway. PMID: 23695020
    12. Our data suggests that eEF1A2 plays an important role in prostate cancer development, especially in inhibiting apoptosis. PMID: 24853801
    13. The activation level of the EEF1A2/PI3K/AKT/mTOR/MDM4 axis significantly influences the survival probability of hepatocellular carcinoma patients PMID: 24285179
    14. There was no significant correlation between eEF1A2 protein and mRNA expression levels. Negative immunostaining of eEF1A2 predicted for poor prognosis of NSCLC. PMID: 24510995
    15. results provide evidence of eEF1A2 as a potential therapeutic target in the treatment of aggressive pancreatic cancer PMID: 23739844
    16. Data conclude that the interaction of p16(INK4a) with eEF1A2, and subsequent downregulation of the expression and function of eEF1A2 is a novel mechanism explaining the anti-proliferative effects of p16(INK4a). PMID: 23444377
    17. a role for a RACK1/JNK/eEF1A2 complex in the quality control of newly synthesized polypeptides in response to stress PMID: 23608534
    18. The eEF1A2 likely plays an important role in mammary neoplasia and acinar development. PMID: 21851817
    19. Observational study of gene-disease association, gene-gene interaction, and genetic testing. (HuGE Navigator) PMID: 20864512
    20. Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to breast tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases. PMID: 20819441
    21. EEF1A2 may play contribute to the induction or progression of some plasmacytomas and a small percentage of multiple myeloma. PMID: 20505761
    22. overall, this study does not support an associated between statin use and prostate cancer but a reduced risk cannot be ruled out. PMID: 18322813
    23. this population-based study of individuals with incident AD, use of statins and beta-blockers was associated with delay of functional decline. PMID: 18978249
    24. the interaction of ZPR1 and eEF1alpha PMID: 19966453
    25. This is a putative oncogene in ovarian cancer. PMID: 12053177
    26. Review. EEF1A2 is an important ovarian oncogene. The protein elongation network can activate tumorigenesis and inhibit apoptosis. PMID: 14588074
    27. These results indicate that the use of cellular promoters such as those for EF-1alpha and ubiquitin C might direct prolonged gene expression in hematopoietic and mesenchymal progenitor cells. PMID: 15893736
    28. eEF1A2 may have a role in cytoskeletal remodelling or apoptosis in breast neoplasms PMID: 16156888
    29. Overexpression of EEF1A2 and KCIP-1 is associated with lung adenocarcinoma PMID: 16369491
    30. there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta PMID: 17088255
    31. Regulates oncogenesis through Akt-dependent cytoskeletal remodeling. PMID: 17130842
    32. The oncogenicity of eEF1A2 may be related either to its role in protein synthesis or to potential non-canonical functions. PMID: 17437010
    33. The expression level of EEF1A2 correlates with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grades. PMID: 17825975
    34. EEF1A2 is highly homologous and functionally similar to the EEF1A1 oncogene, and was found to be restricted only to the normal tissues of the heart, brain, and skeletal muscle PMID: 17908984
    35. Study finds that eEF1A2 stimulates formation of filopodia by increasing the cellular abundance of cytosolic and plasma membrane-bound phosphatidylinositol-4,5 bisphosphate. PMID: 18474610
    36. eEF1A2 might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene. PMID: 19138673
    37. Studies indicate that the EEF1A2 abnormal expression in cancers correlates with a poor prognosis. PMID: 19723040

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 33 (EIEE33); Mental retardation, autosomal dominant 38 (MRD38)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
  • 組織特異性:
    Brain, heart, and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 3192

    OMIM: 602959

    KEGG: hsa:1917

    STRING: 9606.ENSP00000217182

    UniGene: Hs.433839



主站蜘蛛池模板: 伊人色综合久久天天小片| 国内精品久久久久久tv| 精品国产成人av在线| 国产精品刮毛| 老司机免费的精品视频| 2021亚洲国产成a在线| 亚洲日韩欧洲乱码av夜夜摸| 老司机午夜免费精品视频| 国产在线看片免费视频| 国产精品人妻在线观看| 成人无码影片精品久久久| 337p日本欧洲亚洲大胆色噜噜| 国产精品美女久久久网站动漫| 国产成人精品午夜福利不卡| 成人精品一区日本无码网| 无码日本精品xxxxxxxxx| 亚洲成av人在线观看天堂无码| 四虎成人精品永久在线视频| 国产内射爽爽大片视频社区在线| 欧美大屁股流白浆xxxx| a∨在线视频播放| 无码国产成人午夜电影在线观看 | 人妻少妇88久久中文字幕| 国产乱人伦av麻豆网| 狠狠色噜噜狠狠色综合久| 欧美国产日韩亚洲中文| 色妞ww精品视频7777| 婷婷五月深深久久精品| 国产精品女同一区二区在线 | 国产午夜精品理论片| 亚洲伊人色综合www962| 亚洲bbw性色大片| 国产艳妇av在线观看果冻传媒| 日本三级香港三级人妇三| 天天鲁在视频在线观看| 久久香蕉国产线看观看精品yw| 久久精品人妻一区二区三区| 国产精品a久久777777| √天堂中文官网8在线| 中文字幕乱码一区av久久不卡| 久久亚洲精品无码观看不卡|