在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EDN3 Antibody

  • 中文名稱:
    EDN3兔多克隆抗體
  • 貨號:
    CSB-PA111567
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA111567(EDN3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA111567(EDN3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    EDN3
  • 別名:
    EDN3 antibody; EDN3_HUMAN antibody; Endothelin 3 antibody; Endothelin-3 antibody; ET 3 antibody; ET-3 antibody; PPET3 antibody; Preproendothelin 3 antibody; Preproendothelin-3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human EDN3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • 基因功能參考文獻:
    1. the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported. PMID: 28880927
    2. genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer. PMID: 27863272
    3. EDN3 expression in left internal mammary arteries depends on tissue harvesting technique. PMID: 24647318
    4. Down-regulated expression of ET3 attenuates the malignant behaviors of human melanoma cells partially by decreasing the expression of SPARC. PMID: 23904381
    5. Waardenburg syndrome type II and mutations of EDNRB, EDN3 and SOX10 genes are responsible for Waardenburg syndrome type IV. (review) PMID: 24379252
    6. Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3. PMID: 23515723
    7. These data suggest that autocrine EDN3/EDNRB signaling is essential for maintaining GSCs. Incorporating END3/EDNRB-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence. PMID: 22013079
    8. Finding suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and that the EDN3 mutation acts as a phenotype modifier. PMID: 19556619
    9. EDN3 may be considered as a common susceptibility gene for sporadic Hirschsprung disease in a low-penetrance fashion. PMID: 20009762
    10. Mutations are found in Hirschsprung's disease in a Chinese population. PMID: 14669347
    11. KEL6 red blood cells have endothelin-3-converting enzyme activity PMID: 16423827
    12. neither polymorphism nor mutation was observed in EDN3 in Chinese Hirschprung disease patients PMID: 17554617
    13. Endothelin-3 molecule is specifically upregulated in metastatic melanoma cells, showing that an abnormal autocrine stimulation pathway involving ET-3 is present in metastatic melanoma cells. PMID: 18346402
    14. Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells. PMID: 18722093
    15. ET3 induced activation of IkappaB & MAPK in epithelial cells. ET3 is involved in regulating human colonic epithelial cell proliferation & survival, particularly for goblet cells. PMID: 18832450
    16. In conclusion, Multiplex Ligation-dependent Probe Amplification assessment of rearrangements in the RET proto-oncogene and in 3 other associated genes, ZEB2, EDN3 and GDNF did not show any variants in 80 sporadic Hirschsprung disease patients. PMID: 19183406
    17. Report on spanish cases of Waardenburg syndrome type 4 with novel mutations in EDN3 and SOX 10 genes. PMID: 19764030

    顯示更多

    收起更多

  • 相關疾病:
    Hirschsprung disease 4 (HSCR4); Congenital central hypoventilation syndrome (CCHS); Waardenburg syndrome 4B (WS4B)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Endothelin/sarafotoxin family
  • 組織特異性:
    Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • 數據庫鏈接:

    HGNC: 3178

    OMIM: 131242

    KEGG: hsa:1908

    STRING: 9606.ENSP00000337128

    UniGene: Hs.1408



主站蜘蛛池模板: 97久久草草超级碰碰碰| 人人人爽人人爽人人av| 日本亚洲欧洲另类图片| 日韩成人av无码一区二区三区| 中文字幕 人妻熟女| 亚洲日韩精品a∨片无码加勒比| 日韩精品无码中文字幕一区二区| 国产成+人+综合+亚洲欧美| 超薄丝袜足j好爽在线| 99精品人妻无码专区在线视频区| 2018年亚洲欧美在线v| 无码人妻少妇久久中文字幕蜜桃| 中文字幕无码免费久久99| 国产麻豆精品一区二区三区v视界| 四虎影视精品永久在线观看| 中国少妇videos呻吟| 国产精品激情| 免费无码成人片| 国产粉嫩小泬在线观看泬| 人人超人人超碰超国产| 内射国产内射夫妻免费频道| 免费人成在线观看网站品善网| 亚洲一卡2卡三卡4卡国色天香| 国产成人毛片在线视频| 久久久www免费人成精品| 久久精品国产首页027007| 精品美女国产互换人妻| 欧美拍拍视频免费大全| 亚洲gv猛男gv无码男同| 人妻丰满熟妇a无码区| 欲香欲色天天综合和网| 天天色影网| 蜜臀av网站在线| 上海少妇高潮狂叫喷水了| 男男啪啪激烈高潮cc漫画免费| 97se亚洲国产综合自在线尤物| 尹人香蕉99久久综合网站| 在办公室被c到呻吟的动态图| 岛国片人妻三上悠亚| 女人被躁到高潮免费视频软件| 狠狠色婷婷久久综合频道毛片|