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ECSCR Antibody, Biotin conjugated

  • 中文名稱:
    ECSCR兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA007385LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ECSCR Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ECSCR
  • 別名:
    ECSCR antibody; ECSCR_HUMAN antibody; Endothelial cell-specific chemotaxis regulator antibody; Endothelial cell-specific molecule 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Endothelial cell-specific chemotaxis regulator protein (25-124AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
  • 基因功能參考文獻:
    1. Low expression level of ECSCR is associated with evasive resistance and disease progression in cancer. PMID: 26956051
    2. identification of three novel full-length splice variants potentially encoding different protein isoforms PMID: 23147565
    3. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. PMID: 23393131
    4. ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway. PMID: 21720547
    5. Characterize a novel cell surface protein ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. PMID: 18556573
    6. ECSM2 is involved in cell-shape changes and actin cytoskeletal rearrangement, suppresses tyrosine phosphorylation signaling and ECSM2 can cross-talk with EGFR to attenuate the EGF-induced cell migration. PMID: 19267780
    7. Knockdown of ARIA in HUVECs significantly reduced endothelial apoptosis without affecting either cell migration or proliferation. ARIA knockdown significantly increased inhibitor of apoptosis cIAP-1 and cIAP-2 protein expression PMID: 19416853
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 19240791

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  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cytoplasm.
  • 蛋白家族:
    ECSCR family
  • 組織特異性:
    Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.
  • 數據庫鏈接:

    HGNC: 35454

    KEGG: hsa:641700

    UniGene: Hs.483538



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