在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EAF2 Antibody

EAF2 Antibody

  • 中文名稱：
    EAF2兔多克隆抗體
  • 貨號：
    CSB-PA856910DSR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA856910DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA856910DSR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EAF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EAF2
  • 別名：
    BM 040 antibody; BM040 antibody; EAF 2 antibody; EAF2 antibody; EAF2_HUMAN antibody; Ehrlich S II transcriptional activator factor antibody; ELL associated factor 2 antibody; ELL-associated factor 2 antibody; Festa antibody; Testosterone regulated apoptosis inducer and tumor suppressor antibody; Testosterone regulated apoptosis inducer and tumor suppressor protein antibody; Testosterone-regulated apoptosis inducer and tumor suppressor protein antibody; TRAITS antibody; U19 antibody; Uncharacterized bone marrow protein BM 040 antibody; Uncharacterized bone marrow protein BM040 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ELL-associated factor 2 protein (1-170AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional transactivator of TCEA1 elongation activity. Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
  • 基因功能參考文獻：
    1. Simultaneous inactivation of EAF2 and p53 can act to activate STAT3 and drive prostate tumorigenesis. PMID: 29518696
    2. The results indicated that Eaf2 was able to effectively suppress H2O2induced apoptosis of HLE cells via inhibition of caspase 3 production and activation of Wnt3a signaling. PMID: 29257273
    3. EZH2 promotes tumorigenesis and malignant progression in part by activating glycolysis through an EAF2-HIF1alpha signaling axis. PMID: 27259264
    4. Concurrent p53 nuclear staining and EAF2 downregulation was associated with high Gleason score In human prostate cancer specimens. PMID: 29029019
    5. analysis showed that EAF2 and EAF1 are required for the recruitment and retention of Ku70/Ku80 to DNA damage sites and play a functional role in nonhomologous end-joining DNA repair. Findings provide evidence for EAF2 as a key factor mediating androgen protection of DNA damage via Ku70/Ku80 in prostate cancer cells. PMID: 27721405
    6. EAF2 binding does not alter Smad3 phosphorylation but causes Smad3 cytoplasmic retention, competes with Smad4 for binding to Smad3, and prevents p300-Smad3 complex formation PMID: 26370086
    7. Findings suggest that regulation of the AR signaling pathway, cell proliferation, and migration through FOXA1 represents an important mechanism of EAF2 suppression of prostate carcinogenesis. PMID: 25808853
    8. Together these findings identify a novel physical and functional interaction between EAF2 and the Rb pathway. PMID: 24727455
    9. EAF2 bound to and suppressed HIF-1alpha. PMID: 24421387
    10. the role of the EAF2 in response to simvastatin and lovastatin in HCT-116 colon cancer cells PMID: 21483694
    11. Data suggest that U19/EAF2 regulates the expression of TSP-1 via blocking p53 repression of the TSP-1 promoter. PMID: 19826414
    12. U19 is growth inhibitory and tumor suppressive and that the disruption of androgen-dependent growth inhibition via U19 down-regulation is commonly associated with prostate cancer progression. PMID: 12907652
    13. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. PMID: 16006523
    14. ELL may be an important factor required for U19/Eaf2 function because U19/Eaf2 nuclear localization and transactivation activity are essential for its function as a transcription factor. PMID: 16114057
    15. FB1 is an important binding partner and a functional regulator of U19/EAF2, EAF1, and/or ELL. PMID: 17395368

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle.
  • 蛋白家族：
    EAF family
  • 組織特異性：
    Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes.
  • 數據庫鏈接：

    HGNC: 23115

    OMIM: 607659

    KEGG: hsa:55840

    STRING: 9606.ENSP00000273668

    UniGene: Hs.477325



主站蜘蛛池模板： 精品国产你懂的在线观看| 色鬼7777久久| 97色成人综合网站| 国产剧情无码播放在线观看| 美女内射毛片在线看3d| 欧美性xxxx狂欢老少配| 色综合天天无码网站| 亚洲中文字幕a∨在线| 国产欧美va欧美va香蕉在线| 无码国产精品一区二区免费式直播| 无码中文av有码中文av| av高清无码 在线播放| 免费网站内射红桃视频| 中文无码乱人伦中文视频在线| 老子午夜精品无码| 国产沙发午睡系列999| 色婷婷五月综合色啪网| 男女性色大片免费网站| 亚洲国产精彩中文乱码av| 草裙社区精品视频三区免费看 | 性欧美欧美巨大69| 色婷婷久久久swag精品| 最新精品露脸国产在线| av国産精品毛片一区二区视频| 久久久久国产精品免费免费搜索| 性欧美激情aa片在线播放| 一区二区视频传媒有限公司 | 亚洲精品欧美综合一区二区| 亚洲成年轻人电影网站www| 国内女人喷潮完整视频| 国产精品亚洲综合一区在线观看 | 日本无遮挡边做边爱边摸| 亚洲色播爱爱爱爱爱爱爱| 日日摸日日碰夜夜爽免费| 免费少妇荡乳情欲视频| 国产无套内射久久久国产| 在线综合亚洲欧美网站| 亚洲熟妇av综合网五月| 牛牛视频一区二区三区| 精品亚洲一区二区三区在线播放| 国产多人群p刺激交换视频|