在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DYRK1B Antibody

DYRK1B Antibody

  • 中文名稱：
    DYRK1B兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007310GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DYRK1B
  • 別名：
    AOMS3 antibody; Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B antibody; Dual specificity tyrosine phosphorylation regulated kinase 1B antibody; Dual specificity tyrosine-phosphorylation-regulated kinase 1B antibody; DYR 1B antibody; DYR1A antibody; DYR1B antibody; DYR1B_HUMAN antibody; DYRK 1B antibody; Dyrk1b antibody; Minibrain related kinase antibody; Minibrain-related kinase antibody; MIRK antibody; Mirk protein kinase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DYRK1B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
  • 基因功能參考文獻(xiàn)：
    1. Dyrk1B was overexpressed in breast cancer tissues and cells and correlates with FoxO1 phosphorylation and cell proliferation. PMID: 28554575
    2. High DYRK1B expression is associated with pancreatic and skin cancers. PMID: 26784250
    3. The study shows that DYRK1B is a novel ERK2 substrate, uncovering new links between two kinases involved in cell fate decisions. PMID: 26346493
    4. Data reveal a novel role for miR-9 in regulation of the NFAT pathway by targeting KPNB1 and DYRK1B. PMID: 25696812
    5. NKX3.1 and DYRK1B were shown to interact via the DYRK1B kinase domain. In vitro kinase assay showed that DYRK1B phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover. PMID: 25777618
    6. Upregulation of Mirk mRNA expression is mediated by CREB binding to two sites in the Mirk promoter upstream of the transcription start site and one site within exon 4. PMID: 24590896
    7. A founder mutation was identified in DYRK1B, substituting cysteine for arginine at position 102 in 3 families with metabolic syndrome. PMID: 24827035
    8. DYRK1B is a novel Thr(286)-CCND1 kinase that acts independently of GSK3beta to promote CCND1 degradation. PMID: 24134204
    9. Mirk/Dyrk1B plays an important role in ovarian cancer cell survival through modulating FoxO translocation. PMID: 22159921
    10. In line with a redirection of autocrine toward paracrine HH signaling by a KRAS-DYRK1B network, we find high levels of GLI1 expression restricted to the stromal compartment and not to SHH-expressing tumor cells in pancreatic adenocarcinoma. PMID: 20512148
    11. the kinase Mirk is essential for the growth and survival of osteosarcoma cells. PMID: 20042639
    12. activation by MKK2 and role as transcriptional activator of HNF1alpha PMID: 11980910
    13. p38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating PMID: 12384504
    14. Mirk is anti-apoptotic in myoblasts PMID: 15851482
    15. Mirk is a survival factor for pancreatic ductal adenocarcinoma. Because knockout of Mirk does not cause embryonic lethality, Mirk is not essential for normal cell growth. PMID: 16618736
    16. This review summarizes the known regulators and functions of Mirk kinase and outlines opportunities for future studies of Mirk in the fields of muscle and tumor biology. PMID: 16845176
    17. GSK-3beta but also DYRK1B modulates cyclin D1 subcellular localization by the phosphorylation of Thr(288). These results suggest that DIF-3 induces degradation of cyclin D1 through the GSK-3beta- and DYRK1B-mediated threonine phosphorylation in HeLa cells PMID: 17046823
    18. BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk PMID: 18818203
    19. Quiescent pancreatic cancer cells depleted of Mirk became less viable because they were damaged by ROS, and had increased levels of G(1) cyclins to prime cells to escape quiescence. PMID: 19351855
    20. Mirk, through regulating cyclin D turnover, and the CDK inhibitor p27, as shown by depletion studies, functioned independently and additively to regulate the exit of tumor cells from quiescence. PMID: 19542220

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Abdominal obesity-metabolic syndrome 3 (AOMS3)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
  • 組織特異性：
    Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3092

    OMIM: 604556

    KEGG: hsa:9149

    STRING: 9606.ENSP00000312789

    UniGene: Hs.130988



主站蜘蛛池模板： 精品一卡二卡三卡四卡网站 | 97se亚洲国产综合自在线观看| 亚洲最大成人一区久久久| 2018年秋霞无码片| 亚洲最大av网站在线观看| 国产日韩欧美| 中文在线а√在线天堂中文| 天天躁日日躁狠狠躁人妻| 天堂资源中文| 无码免费毛片手机在线无卡顿| 日本又色又爽又黄的视频免| 超清精品丝袜国产自在线拍 | 韩国乱码伦视频免费| 国产熟妇高潮呻吟喷水| 欧美另类又黄又爽的a片| 中文字幕一区二区三区乱码| 女人喷液抽搐高潮视频| 国产99久久亚洲综合精品西瓜tv| 人人爽人人添人人超| 亚洲欭美日韩颜射在线二| 日韩精品a片一区二区三区妖精 | 噜噜色综合天天综合网mp3| 亚洲男人的天堂av手机在线观看 | 亚洲一区在线日韩在线尤物| 国产性天天综合网| 十八禁视频网站在线观看| 国产高清卡1卡2卡3麻豆| 亚洲综合激情七月婷婷| 国产成人a亚洲精v品无码| 国产亚洲高清国产拍精品| 又黄又湿啪啪响18禁| 日日夜夜撸啊撸| k频道国产在线观看| 中文字幕乱码久久午夜不卡| 99精品国产一区二区三区不卡| 精品国产a∨无码一区二区三区| 国产在线精品一区二区在线看| 亚洲乱码中文字幕综合234| 337p大胆啪啪私拍人体| 国产精品亚洲w码日韩中文 | 无码喷水一区二区浪潮av|