在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DYNC2H1 Antibody

  • 中文名稱:
    DYNC2H1兔多克隆抗體
  • 貨號:
    CSB-PA818763LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA818763LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA818763LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA818763LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: DYNC2H1 antibody at 2.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DYNC2H1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DYNC2H1
  • 別名:
    Cytoplasmic dynein 2 heavy chain 1 antibody; Cytoplasmic dynein 2 heavy chain antibody; DYHC2_HUMAN antibody; DYNC2H1 antibody; Dynein cytoplasmic heavy chain 2 antibody; Dynein heavy chain 11 antibody; Dynein heavy chain isotype 1B antibody; hDHC11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cytoplasmic dynein 2 heavy chain 1 protein (1928-2065AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,DYNC2H1 Antibody (CSB-PA818763LA01HU),的標記方式是Non-conjugated。對于DYNC2H1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA818763LB01HU DYNC2H1 Antibody, HRP conjugated ELISA
    FITC CSB-PA818763LC01HU DYNC2H1 Antibody, FITC conjugated
    Biotin CSB-PA818763LD01HU DYNC2H1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.
  • 基因功能參考文獻:
    1. This is the first report of prenatal diagnosis of DYNC2H1 mutations causing Short-rib polydactyly syndrome (SRPS) Type III in a fetus with increased BPD associated with polyhydramnios in China. PMID: 29359448
    2. In all three cases, exome sequence analysis revealed compound heterozygosity for mutations in DYNC2H1, which encodes the main component of the retrograde IFT A motor, cytoplasmic dynein 2 heavy chain 1. Thus SRP type I, II, III and asphyxiating thoracic dystrophy (ATD), which also result from DYNC2H1 mutations. PMID: 27925158
    3. Compound heterozygous mutations in DYNC2H1 and ALOX15 were identified in miscarriages from two families with RPL. DYNC2H1 is involved in cilia biogenesis and has been associated with fetal lethality in humans. ALOX15 is expressed in placenta and its dysregulation has been associated with inflammation, placental, dysfunction, abnormal oxidative stress response and angiogenesis. PMID: 26826164
    4. next-generation panel sequencing identified novel mutations in the DYNC2H1 gene. The fetus was compound heterozygous for both a missense mutation c.8313A > T and a frameshift mutation c.10711_10714delTTTA in the DYNC2H1 gene, which were inherited from the mother and father, respectively PMID: 27323140
    5. Compound heterozygous mutation in DYNC2H1 gene is associated with severe short-rib polydactyly syndrome type III. PMID: 25410398
    6. Gene-based association analyses shows nominal significant association with multifocal fibromuscular dysplasia for cynein cytoplasmic heavy chain 1. PMID: 26147384
    7. a DYNC2H1 mutations causing SRPS III PMID: 25982780
    8. Partial depletion of giantin or of WDR34 leads to an increase in cilia length consistent with the concept that giantin acts through dynein-2. PMID: 24046448
    9. Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement. PMID: 23456818
    10. This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations. PMID: 22499340
    11. In an in vitro MT gliding assay, both dynein-1 and dynein-2 showed minus-end-directed motor activities. PMID: 21723285
    12. Semi-quantitative RT-PCR experiments with 6 of those genes confirmed higher expression of DNCH2, ARHGEF6, NPM1 and SRI and lower expression of NRGN and TM4SF2 in GBM tumors. PMID: 16320026
    13. short-rib polydactyly syndrome affected individuals were homozygous for an exon 12 missense mutation that predicted the amino acid substitution R587C PMID: 19361615
    14. ATD and SRP type III are variants of a single disorder belonging to the ciliopathy group. PMID: 19442771

    顯示更多

    收起更多

  • 相關疾病:
    Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium axoneme. Cell membrane; Peripheral membrane protein. Cytoplasm.
  • 蛋白家族:
    Dynein heavy chain family
  • 數據庫鏈接:

    HGNC: 2962

    OMIM: 603297

    KEGG: hsa:79659

    STRING: 9606.ENSP00000381167

    UniGene: Hs.503721



主站蜘蛛池模板: 亚洲欧美日韩中文加勒比| 欧美精品18videos性欧美| 伊人色综合网久久天天| 亚洲人成图片小说网站| 国产又粗又大又黄| 国产精品ⅴ无码大片在线看| 国产中年熟女高潮大集合| 国产制服丝袜亚洲高清| 婷婷成人五月综合激情| 国产无遮挡又黄又爽高潮| 亚洲精品一区| 日韩久久无码免费毛片软件| 久久亚洲国产精品影院| 欧美成人午夜性视频| 欧美人与zoxxxx另类| 人人澡人人透人人爽| 国产麻豆 9l 精品三级站| 国产亚洲tv在线观看| 男女啪啪高清无遮挡免费| 国产精品区免费视频| 精品无人区卡一卡二卡三乱码| 久久精品香蕉绿巨人登场| 国产精品高潮呻吟av久久男男| 午夜天堂av天堂久久久| 亚洲中文字幕无码av永久| 2020年国产精品| 露脸内射熟女--69xx| 少妇无码吹潮| 久久精品无码一区二区无码| 色欲天天天综合网| 天堂无码人妻精品av一区| 精品久久久久久中文字幕| 狠狠爱亚洲五月婷婷av| 久久国产精品免费一区| 国产狂喷潮在线观看中文| 欧美人妻一区二区三区| 亚洲熟妇中文字幕日产无码| 无遮挡18禁啪啪免费观看| 国产爆乳无码视频在线观看3| 四虎国产精品成人免费久久| 国产97色在线 | 欧洲|