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  4. DYNC1LI2 Antibody

DYNC1LI2 Antibody

  • 中文名稱：
    DYNC1LI2兔多克隆抗體
  • 貨號：
    CSB-PA007296GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DYNC1LI2
  • 別名：
    Cytoplasmic dynein 1 light intermediate chain 2 antibody; cytosolic antibody; DC1L2_HUMAN antibody; DNCLI2 antibody; Dync1li2 antibody; Dynein cytoplasmic 1 light intermediate chain 2 antibody; Dynein light intermediate chain 2 antibody; dynein light intermediate chain 2 cytosolic antibody; dynein; cytoplasmic; light intermediate polypeptide 2 antibody; LIC-2 antibody; LIC2 antibody; LIC53/55 antibody; OTTHUMP00000174820 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DYNC1LI2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
  • 基因功能參考文獻：
    1. Cortically localized dynein, essential for maintaining correct spindle orientation, consists majorly of LIC2-dynein, which interacts with cortical 14-3-3 epsilon- zeta and Par3, conserved proteins required for orienting the spindle. PMID: 28003657
    2. This study uncovers a novel functional hierarchy during mitotic checkpoint inactivation between the closely related but homologous LIC subunits of cytoplasmic dynein. PMID: 27441562
    3. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
    4. using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
    5. FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2. PMID: 20214888

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Dynein light intermediate chain family
  • 數據庫鏈接：

    HGNC: 2966

    OMIM: 611406

    KEGG: hsa:1783

    STRING: 9606.ENSP00000258198

    UniGene: Hs.369068



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