在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DVL3 Antibody, Biotin conjugated

  • 中文名稱:
    DVL3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA856442LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DVL3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Dishevelled 3 (homologous to Drosophila dsh) antibody; Dishevelled 3 antibody; Dishevelled 3; dsh homolog (Drosophila) antibody; Dishevelled; dsh homolog 3 (Drosophila) antibody; Dishevelled-3 antibody; DSH homolog 3 antibody; dvl3 antibody; DVL3_HUMAN antibody; KIAA0208 antibody; OTTHUMP00000210777 antibody; OTTHUMP00000210778 antibody; Segment polarity protein dishevelled homolog DVL 3 antibody; Segment polarity protein dishevelled homolog DVL-3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Segment polarity protein dishevelled homolog DVL-3 protein (509-696AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the signal transduction pathway mediated by multiple Wnt genes.
  • 基因功能參考文獻:
    1. Dvl3 is overexpressed in human HCCs. The NP-Dvl3 is the more stable and active form of the protein and enhances HCC stemness. PMID: 28455968
    2. Studied and identified candidate biomarkers of biochemical recurrence (BCR) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR. DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma. PMID: 28107606
    3. Genetic changes between MLH1 and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 genes (p = 0.034). PMID: 28705114
    4. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells. PMID: 26792835
    5. DVL3 transcripts decreased in individuals with major depressive disorder PMID: 26008736
    6. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    7. All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome. PMID: 26924530
    8. data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/beta-catenin signaling pathway. PMID: 25847080
    9. Tumors that responded to IGFIR inhibition contain relatively lower levels of DVL3 protein than resistant tumors. PMID: 25168481
    10. data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5. PMID: 24993822
    11. AMPK activators suppress cervical cancer cell growth by impairing DVL3 protein synthesis via AMPK/mTOR signaling and/or partially promoting the proteasomal degradation of DVL3 PMID: 23301094
    12. A harmful p.Ser175Gly substitution & 3 benign variants (p.Ile353Val, p.Ile384Val, & p.Ala641Thr) were found in a cohort of patients with neural tube defects but not in controls. PMID: 22892949
    13. Dvl3 protein transduce signals via the Wnt proteins non canonical pathways, namely via NFAT protein and Src kinase and novel NPM-ALK interacting proteins and possibly NPM-ALK substrates. PMID: 23022960
    14. Letter: report expression of dishevelled-3 and EAAT1 and glutamine metabolism in malignant pleural mesothelioma. PMID: 22569537
    15. Identification of novel post translational modifications of DVL3 by liquid chromatography coupled LTQ-Orbitrap analysis. PMID: 22612246
    16. In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and beta-catenin in the absence of Wnt3A stimulation. PMID: 21667018
    17. The facilitation of Prickle-1 on Dvl3 degradation and the suppression of beta-catenin activity and cell growth suggest that Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway PMID: 17030191

    顯示更多

    收起更多

  • 相關疾病:
    Robinow syndrome, autosomal dominant 3 (DRS3)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    DSH family
  • 數據庫鏈接:

    HGNC: 3087

    OMIM: 601368

    KEGG: hsa:1857

    STRING: 9606.ENSP00000316054

    UniGene: Hs.388116



主站蜘蛛池模板: 一本av高清一区二区三区| 五月花成人网| 国产熟妇勾子乱视频| 少妇性l交大片7724com| 午夜福利片手机在线播放| 无码国内精品久久人妻蜜桃| 国产婷婷综合在线视频| 大地资源中文在线观看官网第二页| 好吊色欧美一区二区三区视频| 小箩莉末发育娇小性色xxxx| 麻豆国产在线精品国偷产拍| 国产欧美另类久久久精品丝瓜 | 黑人大战欲求不满人妻| 国产亚洲婷婷香蕉久久精品| 九色九九九老阿姨| 国产成人福利美女观看视频| 国产亚洲日韩妖曝欧美| 亚洲a无码综合a国产av中文| 国产成人久久精品一区二区三区| 99久久国语露脸精品国产| 亚洲精品欧美精品日韩精品| 精品亚洲成av人在线观看| 野外亲子乱子伦视频丶 | 久久精品第九区免费观看| 五月丁香六月综合缴清无码| 国产亚洲美女精品久久久| 国产在线欧美日韩精品一区| 亚洲不卡1卡2卡三卡入口| 婷婷综合久久中文字幕| 国产精品18久久久久久麻辣| 国产好爽…又高潮了毛片| 亚洲丁香五月激情综合| 国产av无码专区亚洲版综合| 国产精品白丝喷水在线观看| 18禁黄网站禁片免费观看国产| 久久精品日日躁夜夜躁 | 在线观看免费人成视频色9| 国产成人av免费网址| 成人无码a∨电影免费| 国产丶欧美丶日本不卡视频| 毛片tv网站无套内射tv网站|