在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DUSP4 Antibody

  • 中文名稱:
    DUSP4兔多克隆抗體
  • 貨號:
    CSB-PA921264
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA921264(DUSP4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: RAW264.7 cells, Primary antibody: CSB-PA921264(DUSP4 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Dual specificity phosphatase 4 antibody; Dual specificity protein phosphatase 4 antibody; Dual specificity protein phosphatase hVH2 antibody; DUS4_HUMAN antibody; DUSP 4 antibody; Dusp4 antibody; HVH 2 antibody; HVH2 antibody; MAP kinase phosphatase 2 antibody; Mitogen activated protein kinase phosphatase 2 antibody; Mitogen-activated protein kinase phosphatase 2 antibody; MKP 2 antibody; MKP-2 antibody; MKP2 antibody; Serine/threonine specific protein phosphatase antibody; TYP antibody; Typ1 antibody; VH 2 antibody; VH1 homologous phosphatase 2 antibody; VH2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human DUSP4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:150
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
  • 基因功能參考文獻:
    1. This study was aimed to investigate the correlation of dual-specificity phosphatase 4 (DUSP4) expression with clinicopathologic features and overall survival in patients with GC and explore the effects of sanguinarine on tumour growth and invasion in GC cells (SGC-7901 and HGC-27) and underlying molecular mechanisms PMID: 27957827
    2. Study revealed that DUSP4 expression was apparently downregulated in the deep region of colorectal cancer (CRC) tissues compared with the superficial region, and that ERK phosphorylation was conversely increased in the deep region relative to the superficial region. Also, downregulation of DUSP4 in CRC might promote cell proliferation and invasiveness through activation of ERK. PMID: 29150975
    3. Results show that DUSP4 gene is under-expressed in ER-negative breast cancer and is deleted in approximately 50 % of breast cancers. Induced DUSP4 expression suppresses both in vitro and in vivo growths of breast cancer cells suggesting that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells. PMID: 27393618
    4. Our findings demonstrate a genetic mechanism by which pancreatic precursor lesions progress to invasive carcinomas and highlight DUSP4 as a novel invasion suppressor PMID: 26941286
    5. DUSP4 is crucial in regulating corticosteroid sensitivity. PMID: 28283554
    6. Data indicate that normalization of dual-specific phosphatase 4 (DUSP4) expression using a specific siRNA improved CD4(+) T-cell activity in idiopathic CD4 lymphopenia (ICL). PMID: 25733583
    7. Ectopic expression of wild-type DUSP4, but not of a phosphatase-deficient mutant, dephosphorylates c-JUN N-terminal kinase (JNK) and induces apoptosis in DLBCL cells. PMID: 25847947
    8. Low DUSP4 expression levels predict recurrence and mortality in triple-negative breast cancer patients PMID: 25281216
    9. Instead, autophagic cell death was the major consequence, and our investigation of mechanisms suggested it is mediated via the dual specificity phosphatase-4 (DUSP4) dependent ERK inactivation pathway PMID: 25027955
    10. DUSP4 attenuates ERK signaling and reduces cell viability, suggesting that the novel crosstalk between NFkappaB and mitogen activated protein kinase pathways contributes to cell survival. PMID: 23812841
    11. Enforced expression of DUSP4 reduced the CD44(+)/CD24(-) population in multiple BLBC cell lines in a MEK-dependent manner, limiting tumor formation of claudin-low SUM159PT cells in mice. PMID: 23966295
    12. high DUSP4 expression was associated with a worse overall survival and with clinical characteristics typical for BRAF mutant patients PMID: 23875912
    13. There was no significant correlation between DUSP4 expression and KRAS mutation. PMID: 23749251
    14. Increased DUSP4 expression is associated with papillary thyroid carcinoma. PMID: 24222120
    15. MKP2 is a negative regulator of VRK1-mediated histone H3 phosphorylation. PMID: 23223570
    16. DUSP4 functions as part of a negative feedback mechanism in the control of the duration and magnitude of nuclear ERK activation during intestinal tumorigenesis. PMID: 22430215
    17. High DUSP4 is associated with microsatellite instability in colorectal cancer and causes increased cell proliferation. PMID: 22965873
    18. Dusp4 mediates cardiomyopathy caused by LMNA gene mutation. PMID: 23048029
    19. Increased DUSP4 expression in activated T cells in the elderly in part accounts for defective adaptive immune responses. PMID: 22434910
    20. MKP-2 is phosphorylated by ERK and that such phosphorylation leads to stabilization of MKP-2 protein. PMID: 21084841
    21. presence of activating KRAS mutations is significantly correlated to an upregulation of 13 genes (adjusted P-value <0.05), among them DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase PMID: 20725992
    22. Over-expression of MKP-2 had different effects upon the expression of inflammatory proteins due to a reciprocal effect upon JNK and NFkappaB signalling, and also prevented TNF-alpha-mediated endothelial cell death PMID: 20860659
    23. MKP-2 as a common epigenetically silenced gene in glioma, the inactivation of which may play a significant role in glioma development. PMID: 20124482
    24. The occurrence of a novel splice variant of MKP-2 which is unable to bind ERK and may be significant in the dysregulation of MAP kinase activity in certain disease states. PMID: 19843478
    25. Results demonstrate the in vivo specificity of MKP-2 for JNK and not ERK and show that nuclear-targeted JNK is involved in genotoxic stress-induced apoptosis. PMID: 16038800
    26. MKP2-mediated inactivation of nuclear extracellular signal-regulated protein kinase ERK2 represents a key event in the establishment of replicative cell senescence. PMID: 17145763
    27. E2F-1 is a transcriptional activator of MKP-2 and MKP-2 is an essential cell death mediator in the E2F-1 pathway PMID: 17452331
    28. Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly. PMID: 19415758
    29. Results show that DUSP4 is involved in negative feedback control of EGFR signaling, and provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma. PMID: 19525976

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 數據庫鏈接:

    HGNC: 3070

    OMIM: 602747

    KEGG: hsa:1846

    STRING: 9606.ENSP00000240100

    UniGene: Hs.417962



主站蜘蛛池模板: 男女啪啪激烈高潮喷出gif免费| 竹菊影视欧美日韩一区二区三区四区五区 | 亚洲中文字幕无码永久| 亚洲第一无码专区天堂| 国产精品国产三级国av在线观看| 18级成人毛片免费观看| av无码av天天av天天爽| 国产欧美久久一区二区| 内射夜晚在线观看| 亚洲已满18点击进入在线观看| 午夜亚洲国产理论片中文| 大屁股熟女一区二区三区| 亚洲精品一线二线三线无人区| 亚洲已满18点击进入在线看片| 精品丝袜人妻久久久久久| 亚洲欧洲自偷自拍图片| 在线精品无码字幕无码av| 日本视频高清一道一区| 亚洲乱码一区二三四区ava| 国产女人高潮抽搐叫床视频| 无码熟妇人妻av在线网站| 日本精品人妻无码免费大全| 亚洲精品成人久久久| 蜜臀av国产一区二区三区| 巨大乳女人做爰视频在线看| 国产精品一区二区av不卡| 日韩精品人妻系列无码专区| 四虎一区二区成人免费影院网址| 电影久久久久久| 国内久久婷婷六月综合欲色啪| 99无码熟妇丰满人妻啪啪| 在厨房拨开内裤进入毛片| 欧美又粗又大又硬又长又爽视频| 亚洲欧洲日产国码无码网站| 精品欧美一区二区三区久久久| 天天爽天天爽天天爽| 亚洲aⅴ无码专区在线观看| 尤物tv国产精品看片在线| 少妇人妻丰满做爰xxx| 国产精品岛国久久久久| 国产欧美另类精品久久久|