在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DUSP22 Antibody

  • 中文名稱:
    DUSP22兔多克隆抗體
  • 貨號:
    CSB-PA040032
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DUSP22
  • 別名:
    Dual specificity protein phosphatase 22 antibody; DUS22_HUMAN antibody; Dusp22 antibody; JNK stimulatory phosphatase 1 antibody; JNK-stimulatory phosphatase-1 antibody; JSP 1 antibody; JSP-1 antibody; JSP1 antibody; LMW DSP2 antibody; LMW-DSP2 antibody; Low molecular weight dual specificity phosphatase 2 antibody; MAP kinase phosphatase x antibody; Mitogen activated protein kinase phosphatase x antibody; Mitogen-activated protein kinase phosphatase x antibody; MKP-x antibody; MKPX antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human VHX.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activates the Jnk signaling pathway.
  • 基因功能參考文獻:
    1. JKAP/DUSP22 is downregulated in T cells of systemic lupus erythematosus nephritis PMID: 27557500
    2. Data show that dual specificity phosphatase 22 (DUSP22) functions as a tumor suppressor gene in peripheral T-cell lymphomas (PTCL). PMID: 27626696
    3. findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 mutations in CLL. PMID: 28017968
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Studies suggest that the presence of dual specificity phosphatase 22 (DUSP22) and p63 tumor suppressor protein (TP63) rearrangements might be useful to support a diagnosis of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL). PMID: 26223379
    6. Report morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 gene rearrangements. PMID: 26379151
    7. Reduced DUSP22 expression was found in colorectal cancer specimens. Low expression level of DUSP22 in stage IV patients had a poor survival outcome PMID: 26032091
    8. The structure illuminates the molecular basis for substrate binding and may also facilitate the structure-assisted development of DUSP22 inhibitors. PMID: 25664796
    9. study identified presence of promoter hypermethylation of the DUSP22 gene in Alzheimer's disease(AD); DUSP22 is a likely candidate gene for involvement in the pathogenesis of AD since it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling PMID: 24436131
    10. Biallelic rearrangements of DUSP22 is found in CD30-positive T-cell lymphoproliferative disorders. PMID: 23337887
    11. Firefighters had a higher prevalence of dual specificity phosphatase 22-promoter hypomethylation in blood DNA (P = 0.03) and the extent of hypomethylation correlated with duration of firefighting service (P = 0.04) but not with age. PMID: 22796920
    12. Data show that t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3. PMID: 21030553
    13. a new role for JKAP in the modulation of FAK phosphorylation and cell motility. PMID: 20018849
    14. The crystal structre showed 1 domain with 6 alpha helices & 5 beta strans, a PTP-loop at the active site binding MES, and an Ala instead of a Trp at the substrate-stacking loop. PMID: 17068812
    15. DUSP22 acts as a negative regulator of the estrogen receptor alpha-mediated signaling pathway in breast cancer cells. PMID: 17384676

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 組織特異性:
    Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16077

    KEGG: hsa:56940

    STRING: 9606.ENSP00000345281

    UniGene: Hs.29106



主站蜘蛛池模板: 亚洲精品久久久久久| 国产精品亚洲mnbav网站| 三级网站视频在在线播放| 亚洲精品无码专区| 午夜熟女插插xx免费视频| 国产农村妇女aaaaa视频| 亚洲高请码在线精品av| 精品国产成人网站一区在线| 中文字幕乱码人妻无码久久| 大肉大捧一进一出好爽app| 麻豆蜜桃av蜜臀av色欲av| 久久人妻国产精品31| 高清视频在线观看一区二区三区| 久久婷婷色综合一区二区| 人妻精品制服丝袜久久久| 人成午夜免费大片| 欧美成人a在线网站| 在厨房被c到高潮a毛片奶水| 无码国产精品免费看| 色视频综合无码一区二区三区| 麻豆一区二区99久久久久| 手机看片福利一区二区三区| 青青草国产精品欧美成人| 国产精品线路一线路二| 熟妇与小伙子matur老熟妇e| 国产精品久久久久影院| 色综久久综合桃花网国产精品| 国产播放隔着超薄丝袜进入| 亚洲人成网站18禁止无码| 阳茎伸入女人阳道视频| 夜晚成人18禁区导航网站| 无限看片在线版免费视频大全| 亚洲色播爱爱爱爱爱爱爱| 亚洲精品国产一区二区三| 人妻体验按摩到忍不住哀求继续 | 国产97色在线 | 欧洲| 成年无码av片| 国产精品成人永久在线| 久久精品99无色码中文字幕| 国产成人毛片在线视频| 国产免费久久久久久无码 |