在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DUSP22 Antibody

  • 中文名稱:
    DUSP22兔多克隆抗體
  • 貨號:
    CSB-PA040032
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DUSP22
  • 別名:
    Dual specificity protein phosphatase 22 antibody; DUS22_HUMAN antibody; Dusp22 antibody; JNK stimulatory phosphatase 1 antibody; JNK-stimulatory phosphatase-1 antibody; JSP 1 antibody; JSP-1 antibody; JSP1 antibody; LMW DSP2 antibody; LMW-DSP2 antibody; Low molecular weight dual specificity phosphatase 2 antibody; MAP kinase phosphatase x antibody; Mitogen activated protein kinase phosphatase x antibody; Mitogen-activated protein kinase phosphatase x antibody; MKP-x antibody; MKPX antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human VHX.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activates the Jnk signaling pathway.
  • 基因功能參考文獻:
    1. JKAP/DUSP22 is downregulated in T cells of systemic lupus erythematosus nephritis PMID: 27557500
    2. Data show that dual specificity phosphatase 22 (DUSP22) functions as a tumor suppressor gene in peripheral T-cell lymphomas (PTCL). PMID: 27626696
    3. findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 mutations in CLL. PMID: 28017968
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Studies suggest that the presence of dual specificity phosphatase 22 (DUSP22) and p63 tumor suppressor protein (TP63) rearrangements might be useful to support a diagnosis of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL). PMID: 26223379
    6. Report morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 gene rearrangements. PMID: 26379151
    7. Reduced DUSP22 expression was found in colorectal cancer specimens. Low expression level of DUSP22 in stage IV patients had a poor survival outcome PMID: 26032091
    8. The structure illuminates the molecular basis for substrate binding and may also facilitate the structure-assisted development of DUSP22 inhibitors. PMID: 25664796
    9. study identified presence of promoter hypermethylation of the DUSP22 gene in Alzheimer's disease(AD); DUSP22 is a likely candidate gene for involvement in the pathogenesis of AD since it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling PMID: 24436131
    10. Biallelic rearrangements of DUSP22 is found in CD30-positive T-cell lymphoproliferative disorders. PMID: 23337887
    11. Firefighters had a higher prevalence of dual specificity phosphatase 22-promoter hypomethylation in blood DNA (P = 0.03) and the extent of hypomethylation correlated with duration of firefighting service (P = 0.04) but not with age. PMID: 22796920
    12. Data show that t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3. PMID: 21030553
    13. a new role for JKAP in the modulation of FAK phosphorylation and cell motility. PMID: 20018849
    14. The crystal structre showed 1 domain with 6 alpha helices & 5 beta strans, a PTP-loop at the active site binding MES, and an Ala instead of a Trp at the substrate-stacking loop. PMID: 17068812
    15. DUSP22 acts as a negative regulator of the estrogen receptor alpha-mediated signaling pathway in breast cancer cells. PMID: 17384676

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 組織特異性:
    Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16077

    KEGG: hsa:56940

    STRING: 9606.ENSP00000345281

    UniGene: Hs.29106



主站蜘蛛池模板: 在厨房拨开内裤进入在线视频| 亚洲男人第一av网站| 久久综合亚洲色一区二区三区 | av大片在线无码免费| 亚洲精品欧美二区三区中文字幕| 久久久婷婷五月亚洲97号色| 中文字幕卡二和卡三的视频| 欧美精品亚洲精品日韩专区| 任你躁在线精品免费| 97久久综合区小说区图片区| 潮喷大喷水系列无码视频| 亚洲中文字幕a∨在线| 欧美黑人大战白嫩在线| 一二三四在线观看免费视频| 办公丝袜av一区二区三区| 亚洲精品成人福利网站app| 久久国产一区二区三区| av无码一区二区大桥久未| 护士张开腿被奷日出白浆| 国产v在线在线观看视频免费| 俄罗斯丰满熟妇hd| 亚洲中文字幕日产无码成人片| 性色av一区二区三区人妻| 久久久亚洲一区二区三区| 亚洲国产精品一区第二页| 午夜性色吃奶添下面69影院| 国产在线精品一区二区三区 | 四川丰满少妇被弄到高潮| 护士脱了内裤让我爽了一夜视频| 国产情侣疯狂作爱系列| 亚洲国产精品无码久久久不卡| 久久婷婷五月综合色99啪| 中文字幕日产熟女乱码| 国产一区二区三区不卡在线看| 久久人妻少妇嫩草av无码专区 | 国产精品99爱免费视频| 欧美一进一出抽搐大尺度视频| 国产揉捏爆乳巨胸挤奶视频| 久热爱精品视频线路一| 亚洲国产av无码精品| 狠狠爱亚洲五月婷婷av|