在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DUSP10 Antibody

DUSP10 Antibody

  • 中文名稱：
    DUSP10兔多克隆抗體
  • 貨號：
    CSB-PA929814
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA929814(DUSP10 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA929814(DUSP10 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Dual specificity phosphatase 10 antibody; Dual specificity phosphatase MKP 5 antibody; Dual specificity phosphatase MKP5 antibody; Dual specificity protein phosphatase 10 antibody; DUS10_HUMAN antibody; DUSP 10 antibody; DUSP10 antibody; DUSP10 protein antibody; MAP kinase phosphatase 5 antibody; Mitogen activated protein kinase phosphatase 5 antibody; Mitogen-activated protein kinase phosphatase 5 antibody; MKP 5 antibody; MKP-5 antibody; MKP5 antibody; Serine/threonine specific protein phosphatase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DUSP10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
  • 基因功能參考文獻：
    1. Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants PMID: 29986742
    2. High DUSP10 expression is associated with Metastasis of Hepatocellular Carcinoma. PMID: 28674078
    3. Increased Dusp10 expression is associated with better survival rate in colorectal cancer patients. PMID: 25772234
    4. In females, three SNPs were associated with decreased colorectal cancer risk: rs11118838, rs12724393, and rs908858. However, in males, only one SNP, rs908858, was associated with decreased colorectal cancer risk. PMID: 25973098
    5. Data suggest that vitamin D receptor target genes (DUSP10; THBD, thrombomodulin; NRIP1, nuclear receptor interacting protein 1; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements. PMID: 24975273
    6. Certain mutations in DUSP10 correlate with the incidence of colorectal cancer(CRC). Thus, the function of the DUSP10 gene product may contribute toward CRC in the Han Chinese population. PMID: 23872954
    7. Single nucleotide polymorphism in DUSP10 gene is associated with celiac disease. PMID: 23936387
    8. Depletion of miR-181 family members by miRNA inhibitors enhanced the expression of MKP-5 and suppressed the phosphorylation of p38 MAPK after exposure to PAHs, which promotes cancer cell migration. PMID: 23993976
    9. Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. PMID: 23233447
    10. MKP-5 interacts with ERK, retains it in the cytoplasm, suppresses its activation and downregulates ERK-dependent transcription. PMID: 22711061
    11. A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5. PMID: 22375048
    12. DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. PMID: 22245064
    13. a function for ASC that is distinct from the inflammasome in modulating MAPK activity and chemokine expression and further identify DUSP10 as a novel ASC target. PMID: 21487011
    14. Structural information provides an explanation of constitutive activity of MKP5 as well as the structural insight into substrate-induced activation occurred in other MKPs. PMID: 16806267
    15. Mitogen-activated protein kinase phosphatase-5 (MKP5) mediates anti-inflammatory activities of phytochemicals curcumin, resveratrol and [6]-gingerol. PMID: 17151092
    16. Catalytic domain of MKP5 is in an active conformation, and two loops in the active site have backbone shifts of up to 5 A. PMID: 17400920
    17. The transcription factor ATF2, which is phosphorylated and activated by JNK, is a critical mediator for inducible expression of DUSP1 and DUSP10 in this signaling pathway. PMID: 17681939
    18. p38 MAP kinase down-regulates extracellular signal-regulated kinase via activation of MKP-3 in human monocytes exposed to asbestos to enhance TNF-alpha gene expression. PMID: 18314537

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 組織特異性：
    Expressed in keratinocytes (at protein level). Detected in brain.
  • 數據庫鏈接：

    HGNC: 3065

    OMIM: 608867

    KEGG: hsa:11221

    STRING: 9606.ENSP00000355866

    UniGene: Hs.497822



主站蜘蛛池模板： 成人片黄网站a毛片免费| 色婷婷六月亚洲综合香蕉| 996热re视频精品视频这里| 亚洲精品久久久蜜桃| 无码高潮又爽又黄a片日本动漫| 久久久久国产精品人妻电影| 精品无人码麻豆乱码1区2区| 美女黄18以下禁止观看| 国产69囗曝吞精在线视频| 青楼妓女禁脔道具调教sm | 久久久国产精品无码免费专区| 波多野结衣av无码| 大学生被内谢粉嫩无套| 无码a∨高潮抽搐流白浆| 嫩草av久久伊人妇女超级a| 亚洲一区av无码少妇电影| 麻豆国产人妻欲求不满| 亚洲国产成人精品无码区一本 | 老熟妇乱子交视频一区| 人成午夜免费大片| 国产猛烈高潮尖叫视频免费| 熟妇人妻无码中文字幕老熟妇| 狠狠躁夜夜躁无码中文字幕| 天天爽夜夜爽人人爽免费| 国产乱子夫妻xx黑人xyx真爽| 3p人妻少妇对白精彩视频| 无码一区二区三区av免费蜜桃| 日韩欧群交p片内射中文| 国产麻豆成人精品av| 无套内谢少妇毛片aaaa片免费| 99久久伊人精品综合观看| 精品午夜福利1000在线观看| 午夜视频久久久久一区| 波多野无码黑人在线播放| 国产精品熟妇一区二区三区四区| 国产三级久久久精品麻豆三级| 国内精品国语自产拍在线观看| 亚洲人亚洲人成电影网站色| 国产精品ⅴ无码大片在线看| 国产精品 自在自线| 中文字幕亚洲综合久久青草|