DUS2 Antibody
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中文名稱:DUS2兔多克隆抗體
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貨號:CSB-PA030155
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規格:¥1090
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其他:
產品詳情
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Uniprot No.:
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基因名:DUS2
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別名:DUS2 antibody; DUS2LtRNA-dihydrouridine(20) synthase [NAD(P)+]-like antibody; EC 1.3.1.91 antibody; Dihydrouridine synthase 2 antibody; Up-regulated in lung cancer protein 8 antibody; URLC8 antibody; tRNA-dihydrouridine synthase 2-like antibody; hDUS2 antibody
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宿主:Rabbit
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反應種屬:Human,Mouse
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免疫原:Synthesized peptide derived from the C-terminal region of Human DUS2L.
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式:Liquid
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應用范圍:WB, IHC, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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功能:Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.
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基因功能參考文獻:
- Here, the X-ray crystal structure of a construct of hDus2 encompassing the catalytic and tRNA-recognition domains (residues 1-340) determined at 1.9 A resolution is presented. PMID: 26143927
- This is the first reported case of a tRNA-modifying enzyme (dihydrouridine synthase 2) carrying a dsRNA binding domain used to bind tRNAs. PMID: 26429968
- crystals belonged to space group P2(1) and contained a single molecule of HsDus2L in the asymmetric unit PMID: 22442237
- hDUS2 interacts with protein kinase PKR through its dsRNA binding/dimerization domain and inhibits its kinase activity. PMID: 18096616
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亞細胞定位:Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.
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蛋白家族:Dus family, Dus2 subfamily
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組織特異性:Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).
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數據庫鏈接:
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