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DTNA Antibody

  • 中文名稱:
    DTNA兔多克隆抗體
  • 貨號:
    CSB-PA007216GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DTNA
  • 別名:
    Alpha-dystrobrevin antibody; D18S892E antibody; DRP3 antibody; DTN antibody; DTN-A antibody; DTNA antibody; DTNA_HUMAN antibody; Dystrobrevin alpha antibody; Dystrophin related protein 3 antibody; Dystrophin-related protein 3 antibody; FLJ96209 antibody; LVNC1 antibody; OTTHUMP00000163151 antibody; OTTHUMP00000163152 antibody; OTTHUMP00000163153 antibody; OTTHUMP00000163154 antibody; OTTHUMP00000163155 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DTNA
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
  • 基因功能參考文獻:
    1. Report left ventricular non-compaction associated with Barth Syndrome due to triple mutations in TAZ, DTNA, and SDHA genes in multiple members of one family. PMID: 29508483
    2. we show for the first time localization of alpha-DB2 in nucleoli and Cajal bodies and provide evidence that a-DB2 is involved in the structure of nucleoli and might modulate nucleolar functions PMID: 25959029
    3. our findings suggest that novel mutations in FAM136A and DTNA genes are probably causal variants in FMD. PMID: 25305078
    4. apoptosis-induction in HL-60 cells involves not only classical markers of apoptosis but also a network alpha-DB-associated proteins at the cell membrane, the cytoplasm and nucleus, affecting key cellular transport processes and cellular structure. PMID: 22507200
    5. Results suggest that alpha-dystrobrevin isoforms play a central role in cytoskeleton reorganization via their multiple interactions with actin and actin-associating proteins. PMID: 20111909
    6. Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome. PMID: 21115837
    7. Fundamental functional differences between the alpha-dystrobrevins of mice and humans raises questions about the use of the mouse as a model animal for Duchenne muscular dystrophy. PMID: 19961569
    8. During a cycle of regeneration in tibialis anterior muscle following myonecrosis, alpha-dystrobrevin reaches 50% of the protein level on day 28 by 6.6 days, regenerating more slowly than dystrophin. PMID: 12416719
    9. alpha-dystrobrevin and its splice isoforms have a role in signal transduction in myeloid cells during induction of granulocytic differentiation and/or at the commitment stage of differentiation or phagocytic cells PMID: 12475945
    10. Transgenic expression of either isoform of alpha-dystrobrevin prevented muscle fiber degeneration in knockout mice; however, only alphaDB1 corrected defects at neuromuscular and musculotendinous junctions. PMID: 12604589
    11. patients with deficiency of beta2-syntrophin and alpha-dystrobrevin presented with severe congenital weakness and died in the first year, and patients with deficiency of alpha-DNT had congenital muscular dystrophy with complete external ophthalmoplegia. PMID: 12899872
    12. findings suggest that a-dystrobrevin specifically is associated with the tight junctions during their reorganization PMID: 15834686
    13. Results confirm that dystrophin is required for anchorage of the syntrophin-dystrobrevin subcomplex and suggest that expression of the syntrophin-dystrobrevin complex may be independently regulated through neuromuscular transmission. PMID: 15835271
    14. Dystrobrevin mRNA including exons 11A and 12 was increased in both skeletal and cardiac muscle of DM1 patients. The aberrantly spliced alpha-dystrobrevin isoform was localized to the sarcolemma. PMID: 18299519

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  • 相關疾病:
    Left ventricular non-compaction 1 (LVNC1)
  • 亞細胞定位:
    Cytoplasm. Cell junction, synapse. Cell membrane.
  • 蛋白家族:
    Dystrophin family, Dystrobrevin subfamily
  • 組織特異性:
    Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
  • 數據庫鏈接:

    HGNC: 3057

    OMIM: 601239

    KEGG: hsa:1837

    STRING: 9606.ENSP00000382064

    UniGene: Hs.643454



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