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  4. DTD1 Antibody

DTD1 Antibody

  • 中文名稱：
    DTD1兔多克隆抗體
  • 貨號：
    CSB-PA007214GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DTD1
  • 別名：
    bA379J5.3 antibody; bA555E18.1 antibody; C20orf88 antibody; D tyrosyl tRNA deacylase 1 homolog antibody; D-tyrosyl-tRNA(Tyr) deacylase 1 antibody; DNA unwinding element binding protein antibody; DTD1 antibody; DTD1_HUMAN antibody; DUE B antibody; DUEB antibody; HARS2 antibody; Histidyl tRNA synthetase 2 antibody; Histidyl-tRNA synthase-related antibody; MGC119131 antibody; MGC41905 antibody; pqn 68 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DTD1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes.; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
  • 基因功能參考文獻：
    1. The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A-dependent dephosphorylation. PMID: 25258324
    2. LDI-PCR revealed a fusion between DTD1 exon 4 and PDGFRB exon 12 in the cases with t(5;14)(q33;q32) and t(5;20)(q33;p11). PMID: 24772479
    3. DTD1 variants do not affect the abnormalities of the upper airways in aspirin-intolerant asthma patients PMID: 21479357
    4. The coordinated binding of DUE-B and Cdc45 to origins and the physical interactions of DUE-B, Cdc45, and TopBP1 suggest that complexes of these proteins are necessary for replication initiation. PMID: 20065034
    5. cloning and identification of novel cDNA which may be associated with FKBP25 PMID: 12392168
    6. DUE-B, a c-myc DNA-unwinding element-binding protein, plays an important role in replication in vivo. PMID: 15653697

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
  • 蛋白家族：
    DTD family
  • 組織特異性：
    Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
  • 數據庫鏈接：

    HGNC: 16219

    OMIM: 610996

    KEGG: hsa:92675

    STRING: 9606.ENSP00000366672

    UniGene: Hs.659442



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