在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DSG1 Antibody, FITC conjugated

  • 中文名稱:
    DSG1兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA861938LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) DSG1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DSG1
  • 別名:
    DSG1; CDHF4; Desmoglein-1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Desmoglein-1 protein (384-539AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 基因功能參考文獻(xiàn):
    1. Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation. PMID: 28891468
    2. Compared with immunocompetent patients, kidney transplant recipients systemically treated with calcineurin inhibitors and mycophenolate mofetil exhibited significantly reduced epidermal expression of Dsg1, a regulator of keratinocyte differentiation and barrier function. PMID: 27302902
    3. Study identified DSG1 to be involved in the progressive intestinal injury associated with the development of Crohn's Disease complications via its effect on intestinal cell adhesion. PMID: 28490445
    4. The authors report one recurrent and five novel DSG1 mutations, causing varying patterns of PPK, highlighting the clinical heterogeneity arising from mutations in this gene. PMID: 27534273
    5. Authors report a new family of severe dermatitis, multiple allergies and metabolic wasting syndrome of Asian decent and expand the spectrum of mutations in the DSG1 gene. PMID: 27154412
    6. Case Report: striate palmoplantar keratoderma showing transgrediens in a patient with heterozygote nonsense mutations in DSG1 and SERPINB7. PMID: 27786350
    7. Genetic deletion of sdrD in S. aureus NCTC8325-4 through allelic replacement resulted in decreased bacterial adherence to Dsg1- expressing HaCaT cells in vitro. PMID: 26924733
    8. The results of this study describes the fourth family with a biallelic mutation in the DSG1 gene associated with SAM syndrome, and emphasizes that the presence of PPK and skin fragility with or without additional symptoms should alert clinicians to consider DSG1 deficiency. PMID: 26288349
    9. Desmoglein 1 mutation as cause of SAM syndrome PMID: 26169895
    10. Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. PMID: 24220297
    11. Ectopic expression of Dsg1 in keratinocyte monolayers rescued the UVB-induced differentiation defect PMID: 24594668
    12. The data showed that serum autoantibodies of patients, previously identified as Dsg1 and Dsg3 positive, are able to recognize continuous linear epitope regions of both Dsg1 and Dsg3 proteins using pin-bound overlapping peptides in modified ELISAs. PMID: 23297065
    13. The loss of Bcr or MAL reduced levels of Dsg1 mRNA in keratinocytes, and ectopic expression of Dsg1 rescued defects in differentiation seen upon loss of Bcr or MAL signaling. PMID: 23940119
    14. DSG1 deficiency was associated with increased expression of a number of genes encoding allergy-related cytokines PMID: 23974871
    15. IgG autoantibodies against Dsg1 are mostly raised against preDsg1 and/or C-terminal domains of Dsg1 in healthy Tunisians in the endemic area of pemphigus foliaceus. PMID: 23489520
    16. DSG1 and Erbin cooperate to repress MAPK signaling and promote keratinocyte differentiation. PMID: 23524970
    17. we show that the LJM11 salivary protein from the sand fly are recognized by pemphigus foliaceus autoantibodies against desmoglein 1 PMID: 22798673
    18. Induced gene expression levels of plakoglobin, desmoglein-1 and desmoglein-2 correlated significantly with dilatation of intercellular spaces and basal cell hyperplasia in esophageal mucosa of patients with gastro-oesophageal reflux disease. PMID: 22276604
    19. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases. PMID: 22189787
    20. anti-DSG1 response in fogo selvagem patients may be initiated by sensitization to an environmental allergen PMID: 21191415
    21. KLK5 may promote metastatic dissemination of OSCC by promoting loss of junctional integrity through cleavage of desmoglein 1. PMID: 21163944
    22. Data show that desmoglein 1 expression was required for the adhesive effects of EphA2. PMID: 20861311
    23. Histone deacetylase inhibition up-regulates desmosomal cadherins and prevents the loss of adhesion induced by Dsg1 truncation. PMID: 21075858
    24. localized on corneodesmosomes involved in adhesion PMID: 20116975
    25. data demonstrate the role of epistasis between individual genes in Pemphigus foliaceus susceptibility and illustrate the genetic complexity of organ-specific autoimmune diseases; Epistasis between DSG1 and HLA class II genes PMID: 12058255
    26. Staphylococcal exfoliative toxins act as serine proteases with extremely focused molecular specificity to cleave mouse and human desmoglein 1 (Dsg1) once after glutamic acid residue 381 between extracellular domains 3 and 4. PMID: 12093888
    27. During high-level expression, keratin insertion at cell-cell contact sites was inhibited in desmoglein 1 but not in desmoglein 3, and desmoplakin was stained at cell-cell contact sites in desmoglein 3 but not in desmoglein 1. PMID: 12485422
    28. Desmoglein 1 defined more differentiated cell populations, and was expressed in epidermal suprabasal cells, the inner root sheath, and the innermost layers of the outer root sheath. PMID: 12787134
    29. Signaling pathway initiated by structural changes in the adherens junction in which adherens-junction-derived plakoglobin regulates nuclear transcription by antagonizing the binding of beta-catenin to T cell factor/lymphoid enhancer factor proteins. PMID: 12880414
    30. Specificity of exfoliative toxin cleavage of desmoglein 1 resides not only in simple amino acid sequences but also in its calcium-dependent conformation. PMID: 12880431
    31. a detailed epitope mapping reveals that the conformational epitopes recognized by IgG1 autoantibodies from these PF patients are restricted to the first 161 amino acids of Dsg1, whereas the linear epitopes are spread throughout the entire ectodomain. PMID: 14675185
    32. Dsg1 promotes the formation of intercellular adhesion complexes. PMID: 15606501
    33. a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5 domain of desmoglein 1 PMID: 15610512
    34. T-cell autoreactivity against Dsg1 is seen both in patients with pemphigus foliaceus and in healthy individuals PMID: 16026580
    35. No significant relationship is revealed between genetic variants of autoantigen desmoglein 1 and pemphigus foliaceus in the Brazilian population. PMID: 16242304
    36. desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes PMID: 16286477
    37. perturbation of desmoglein 1 expression has a critical impact on the integrity of tissues experiencing strong mechanical stress. PMID: 16484817
    38. An alternative transcript of DSG1, which contains a 101-bp insertion corresponding to the 3' end of DSG1-intron 6 and introducing a stop codon in the nucleotide sequence, is described. PMID: 17056584
    39. Taken together, our results represent the first demonstration that anti-Dsg1 antibodies induce similar alterations on the subcellular distribution of Dsg1 irrespective of the disease where they come from. PMID: 17058228
    40. novel splice site mutation in the DSG1 gene in palmoplantar keratoderma PMID: 17194569
    41. Data show that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were effective in causing epidermal splitting in human skin and keratinocyte dissociation. PMID: 17640963
    42. IgM anti-Dsg1 are common in fogo selvagem patients in their native environment and uncommon in other pemphigus phenotypes PMID: 17960181
    43. findings show that mRNA of the DSG1 gene is present in normal thymus and that the expression of DSG1 transcript increases with age PMID: 18331528
    44. The level of Dsg1, a marker of differentiating keratinocytes, was antagonistically regulated by two Ca-independent 'novel' nPKC isoforms; i.e. it increased by the differentiation-promoting nPKCdelta and decreased by the growth-promoting nPKCepsilon. PMID: 18637128
    45. Decreased expression of desmoglein 1 is associated with a worse prognosis in head and neck squamous cell carcinoma patients PMID: 18752129
    46. Direct sequencing of cDNA derived from affected skin in one patient failed to reveal a pathogenic mutation, suggesting that SPPK results from haploinsufficiency for DSG1. PMID: 19018793
    47. The desmoglein-specific cytoplasmic region is an intrinsically disordered functional domain with an inducible structure that, along with the membrane proximal region, forms a flexible scaffold for cytoplasmic assembly at the desmosome. PMID: 19136012
    48. Mutations in the desmoglein 1 gene have been indentified in five Pakistani families with striate palmoplantar keratoderma. PMID: 19157795
    49. Pemphigus foliaceus is an autoimmune blistering skin disease characterized by the production of pathogenic IgG autoantibodies directed against desmoglein 1. PMID: 19453789
    50. Data show that Dsg1 is required for maintaining epidermal tissue integrity in superficial layers, supports keratinocyte differentiation and suprabasal morphogenesis, and is required for suppression of epidermal growth factor receptor signaling. PMID: 19546243

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1); Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE)
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 組織特異性:
    Epidermis, tongue, tonsil and esophagus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3048

    OMIM: 125670

    KEGG: hsa:1828

    STRING: 9606.ENSP00000257192

    UniGene: Hs.2633



主站蜘蛛池模板: 中文字幕人妻a片免费看 | 日韩人妻无码免费视频一区二区三区 | 国产成人av在线一区二区三区| 大陆极品少妇内射aaaaa| 牛牛在线视频| 成人免费b2b网站大全在线| 四虎国产精品永久地址入口| 少妇愉情理伦片bd| 久久精品中文字幕| 2020每日更新国产精品视频| 无码福利在线观看1000集| 少妇被又大又粗又爽毛片久久黑人| 99久久国产热无码精品免费| 国产精品美女www爽爽爽视频| 国产精品主播一区二区三区| 在线视+欧美+亚洲日本| 少妇被爽到高潮喷水久久欧美精品| 业余 自由 性别 成熟视频 视频 | 国产av熟女一区二区三区 | 国产福利高颜值在线观看| 免费人成在线观看网站品爱网| 免费看又色又爽又黄的国产软件 | 久99久热只有精品国产15 | 亚洲成av人片在一线观看| 国产婷婷精品av在线| 亚洲日韩欧美在线成人 | 午夜亚洲乱码伦小说区69堂| 视频久re精品在线观看| 播放灌醉水嫩大学生国内精品| 伊人久久五月丁香综合中文亚洲| 无码免费无线观看在线视| 亚洲无线码免费| 日日碰狠狠躁久久躁综合小说| 欧美综合自拍亚洲综合图片区| 好爽太紧了舒服视频| 日本精品高清一区二区| 少妇极品熟妇人妻无码| 亚洲 丝袜 制服 欧美 另类| 玖玖资源站无码专区| 中文字幕精品亚洲无线码二区| 色喜国模李晴超大尺度|